Calcio sérico total e ionizado en el segundo trimestre del embarazo como predictor de preeclampsia

Bermúdez-Peñaloza, X.; Mejia-Montilla, Jorly; Santos-Bolívar, Joel; Torres-Cepeda, Duly; Reyna-Villasmil, Nadia; Fernández-Ramírez, Andreina

doi:10.1016/j.rprh.2016.11.004

Cited by 1 publication

(1 citation statement)

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“…Algunos estudios han demostrado que los cambios en las concentraciones séricas de calcio y magnesio pueden contribuir en la patogénesis de la preeclampsia (7,8). La disminución de las concentraciones séricas de calcio sérico, junto al aumento de sus concentraciones intracelulares, puede provocar aumento de la presión arterial, mientras que el magnesio es importante en el proceso de vasodilatación periférica (9,10). Existen informes que demuestran concentraciones séricas bajas de calcio y magnesio en preeclámpticas (11), mientras que otros informes indican que las concentraciones de ambos oligoelementos presentan valores similares a las embarazadas normotensas (12).…”

Section: Introductionunclassified

Utilidad de la relación calcio/magnesio en el diagnóstico de preeclampsia

Torres-Cepeda,

Reyna-Villasmil,

Mejia-Montilla

et al. 2023

RSOGV

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Objective: To establish the usefulness of the calcium/magnesium ratio in the diagnosis of preeclampsia. Methods: A case-control study was performed between January 2014 and June 2022 on patients who were treated at the Central Hospital “Dr. Urquinaona”, Maracaibo, Venezuela. A group of pregnant women with a diagnosis of preeclampsia (group A, cases) and a control group of pregnant women with maternal age and body mass index similar to the study group (group B, controls) were selected. Demographic characteristics, laboratory parameters, and serum calcium and magnesium concentrations were evaluated. Results: 515 pregnant women were selected, 257 in group A and 258 in group B. Patients in group A had lower serum calcium and magnesium concentrations compared to patients in group B. The calcium/magnesium ratio was also lower in group A than in group B. (p < 0.0001). Analysis of the discriminatory ability of the calcium/magnesium ratio in the diagnosis of preeclampsia showed that the value of 3.44 had a value under the curve of 0.893 (95% confidence interval, 0.867–0.919) with a sensitivity of 66.3% (95%CI, 60.3%-71.8%), specificity 92.6% (95%CI, 88.7%-95.2%). The diagnostic accuracy was 79.4% (95% CI,75.7%–82.7%). Conclusion: The calcium/magnesium ratio is useful in the diagnosis of preeclampsia since its value is significantly lower, compared to healthy normotensive pregnant women.

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