Calcinosis Cutis: Its Relationship to Scleroderma

Muller, Sigfrid A.; Brunsting, Louis A.; Winkelmann, R. K.

doi:10.1001/archderm.1959.01560190017002

Cited by 60 publications

(20 citation statements)

References 9 publications

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“…The radiological abnormalities evident in these children were identical to those described in adult sclerodermatous acro-osteolysis [9].…”

Section: Acro-osteolysissupporting

confidence: 72%

“…The distribution of subcutaneous calcinosis was similar to that occurring in the adult forms of scleroderma [9], with a predilection for the elbows, knees, and fingers. This similarity of radiological appearances to scleroderma was emphasized in four children by the demonstration of terminal phalangeal resorption (acro-osteolysis) in association with finger pulp calcinosis [9] (Figs.…”

Section: Discussionsupporting

confidence: 51%

“…This similarity of radiological appearances to scleroderma was emphasized in four children by the demonstration of terminal phalangeal resorption (acro-osteolysis) in association with finger pulp calcinosis [9] (Figs. 3 and 8).…”

Section: Discussionmentioning

confidence: 70%

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Calcinosis in juvenile dermatomyositis

1978

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Abstract.A retrospective study of the radiographs and clinical records of 39 children with dermatomyositis, followed up at a referral centre for a mean period of eight years, revealed calcinosis in 29 children (18 girls, 11 boys). Clinical presentation of calcinosis was unpredictable and variable, ranging from four months to 12 years after onset of disease. Subcutaneous calcification, often associated with subsequent ulceration of overlying skin, was observed more frequently than calcinosis in intermuscular fascial planes (29: 7). Subcutaneous calcinosis was demonstrated most commonly about the knees and elbows and in the fingers and toes. Intermuscular calcinosis affected the fascial planes around the quadriceps, deltoid, biceps, and the gastrocnemius/soleus muscles.Calcinosis, predominantly of the subcutaneous lesions, regressed spontaneously in eight of 11 children where this could be assessed over a one to four year period. This high rate of spontaneous resolution must complicate evaluation of the efficacy of proposed anti-calcinotic treatments in juvenile dermatomyositis.While no apparent relationship was established between subcutaneous calcinosis, which was present in all 29 of the affected patients, and disease activity or severity, all seven children with the additional, extensive, and 'classical' intermuscular fascial plane calcification developed this complication early and had severe disease.These findings are discussed in relation to previous studies.

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“…The radiological abnormalities evident in these children were identical to those described in adult sclerodermatous acro-osteolysis [9].…”

Section: Acro-osteolysissupporting

confidence: 72%

Section: Discussionsupporting

confidence: 51%

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Calcinosis in juvenile dermatomyositis

1978

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“…Calcinosis cutis is extremely rare in mixed connective tissue disorders 2. Although it is common in scleroderma, it is rare in morphea and was reported in only one of 74 patients by Muller 3. The clinical examination of our patient was not suggestive of such a disorder.…”

Section: Discussionmentioning

confidence: 50%

Large subcutaneous nodules in lower limbs following thyroiditis

Kakar

Byotra

1999

Postgraduate Medical Journal

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A 20-year-old woman was admitted with complaints of fever and polyarthralgia since January 1996. All investigations including collagen markers were negative. The patient was treated with analgesics and showed improvement. In July she noticed a thyroid swelling with low-grade fever, and investigations showed that she was hypothyroid. Antimicrosomal antibodies were positive and antithyroglobulin was negative. Thyroid receptor antibody status was not available. Thyroid fine needle biopsy showed chronic lymphocytic thyroiditis. She was put on thyroid hormone replacement therapy.In February 1997 she noticed multiple subcutaneous lumps in the lower limbs. She also complained of low-grade fever and arthralgia. There was no malar or discoid rash or rash elsewhere on the body. On examination, the lumps were hard, mobile, and non-tender, varying in size from 3-7 cm. She was febrile and had swelling of the small joints of both hands. Investigations showed normal blood picture, erythrocyte sedimentation rate was 130 mm in 1st hour, ANA and dsDNA both were strongly positive. Anti-Sm, and antiphospholipid antibodies (IgG, IgM) were negative. Lupus anticoagulant was positive. Echocardiography showed mild pericardial eVusion. Chest X-ray was normal and X-ray of the hands did not show any erosion. Liver, renal function tests, serum calcium, phosphorus, alkaline phosphatase, parathyroid levels, creatine phosphokinase, barium swallow and pulmonary functions test were all normal. Rheumatoid factor was negative. X-Rays of the lower limbs are shown in figures 1 and 2.

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“…In connective tissue disease, calcinosis is mostly of dystrophic type and it seems to be localized process rather than an imbalance of calcium homeostasis. Calcinosis in connective tissue disease about 9% patient with seleroderma 2,3 and 5% to 20% of adult 4 and 40% to74% of children with dermatomyositis. The existence of calcinosis is indicative of a good prognostic sign of survival but may also be incapacitating.…”

Section: Discussionmentioning

confidence: 99%