Calcinosis cutis following extravasation of calcium chloride

Disseminated linear calcinosis cutis associated with the Koebner phenomenon in an infant with congenital acute monocytic leukaemia

“…These linear deposits occurred in the vein distal to the infusion site and presented 2 h to 24 days after the calcium infusion. 16,17 However, none of these cases resulted in a randomly disseminated pattern such as ours.…”

“…A linear pattern of calcium deposition has previously been reported, but as a result of calcium gluconate infusions. These linear deposits occurred in the vein distal to the infusion site and presented 2 h to 24 days after the calcium infusion 16,17 . However, none of these cases resulted in a randomly disseminated pattern such as ours.…”

Calcinosis cutis: a complication of intravenous administration of calcium glucanate

“…The second factor that is believed to be crucial for the development of calcinosis cutis after extravasation of a calcium‐containing solution is the presence of collagen. In vitro , collagen can trigger apatite deposition from a calcium phosphate solution 3 . In this context, it is notable that the pathologic specimen from our patient demonstrates calcium crystals that are closely associated with the degenerated collagen bundles that occupy the dermis.…”

Sporotrichoid-like calcinosis cutis and calcifications in vessel walls and eccrine sweat glands following intravenous infusion of calcium gluconate

“…The exact mechanism of calcification remains poorly understood; however, local trauma accompanied by a prolonged contact with calcium salts seems to play an important role 1 . In our case, the calcification occurred only on the left forearm and lower arm along the venous track, and not at the other sites of intravenous infusion of calcium gluconate (left leg and right forearm).…”