Calanus oil attenuates isoproterenol-induced cardiac hypertrophy by regulating myocardial remodeling and oxidative stress

Abdellatif, Shrook Y; Fares, Nagui H.; Elsharkawy, Samar H; Mahmoud, Yomna I.

doi:10.1080/01913123.2022.2163016

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…The results demonstrated that the intervention was associated with a reduction in cardiac fibrosis and the remodeling of the extracellular matrix of the myocardium compared to that in the control group. Although the interventions used differed, both were associated with improved outcomes related to oxidative stress, such as increased SOD levels [30,31].…”

Section: Effects Of ω3-pufas On Cardiac Remodeling In Other Hf Modelsmentioning

confidence: 99%

The Role of Omega-3 in Attenuating Cardiac Remodeling and Heart Failure through the Oxidative Stress and Inflammation Pathways

Lazzarin,

Martins,

Ballarin

et al. 2023

Antioxidants

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Cardiac remodeling is defined as molecular, cellular, and interstitial changes that manifest clinically as alterations in the size, shape, and function of the heart. Despite the pharmacological approaches, cardiac remodeling-related mortality rates remain high. Therefore, other therapeutic options are being increasingly studied. This review highlights the role of omega-3 as an adjunctive therapy to attenuate cardiac remodeling, with an emphasis on its antioxidant and anti-inflammatory actions.

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Section: Effects Of ω3-pufas On Cardiac Remodeling In Other Hf Modelsmentioning

confidence: 99%

The Role of Omega-3 in Attenuating Cardiac Remodeling and Heart Failure through the Oxidative Stress and Inflammation Pathways

Lazzarin,

Martins,

Ballarin

et al. 2023

Antioxidants

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“…Previous studies have shown that the oil from C. finmarchicus, and especially the wax esters, have potent effects on gut microbiota and cardiac function and against the development of obesity, insulin resistance and inflammation in mice [14][15][16][17][18] and body composition, functional strength, cardiorespiratory function, metabolic markers and omega-3 index in humans [19][20][21][22], making this oil a possible new marine drug against metabolic syndrome and other pathological conditions.…”

Section: Introductionmentioning

confidence: 99%

A simple method to isolate fatty acids and fatty alcohols from wax esters in a wax-ester rich marine oil

2023

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Calanus finmarchicus is one of the most important zooplankton species in the North Atlantic. The zooplankton is currently being harvested and industrially processed to a marine oil product for human consumption as a marine nutraceutical containing long-chain omega-3 polyunsaturated fatty acids. This oil is very rich in wax esters, a lipid class where fatty acids are esterified to long chain fatty alcohols. In this paper we describe a simple method to 1) isolate the wax esters from the other lipid classes present in the oil, 2) hydrolyze the wax esters, and 3) separate the fatty acids from the fatty alcohol, all by means of solid phase extraction. Starting with an average of 322 mg Calanus oil, we obtained 75 mg fatty alcohols and 63 mg fatty acids. Contrary to previously described techniques, our method neither oxidize the fatty alcohols to fatty acids, nor are the fatty acids methylated, allowing the native, unesterified fatty acids and fatty alcohols to be used for further studies, such as in cell culture experiments to study the metabolic effects of these specific lipid fractions rather than the intact oil or wax esters.

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Antioxidant Protection against Trastuzumab Cardiotoxicity in Breast Cancer Therapy

et al. 2023

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Breast cancer is the most frequent malignant neoplastic disease in women, with an estimated 2.3 million cases in 2020 worldwide. Its treatment depends on characteristics of the patient and the tumor. In the latter, characteristics include cell type and morphology, anatomical location, and immunophenotype. Concerning this latter aspect, the overexpression of the HER2 receptor, expressed in 15–25% of tumors, is associated with greater aggressiveness and worse prognosis. In recent times some monoclonal antibodies have been developed in order to target HER2 receptor overexpression. Trastuzumab is part of the monoclonal antibodies used as targeted therapy against HER2 receptor, whose major problem is its cardiac safety profile, where it has been associated with cardiotoxicity. The appearance of cardiotoxicity is an indication to stop therapy. Although the pathophysiological mechanism is poorly known, evidence indicates that oxidative stress plays a fundamental role causing DNA damage, increased cytosolic and mitochondrial ROS production, changes in mitochondrial membrane potential, intracellular calcium dysregulation, and the consequent cell death through different pathways. The aim of this review was to explore the use of antioxidants as adjuvant therapy to trastuzumab to prevent its cardiac toxicity, thus leading to ameliorate its safety profile in its administration.

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Calanus oil attenuates isoproterenol-induced cardiac hypertrophy by regulating myocardial remodeling and oxidative stress

Cited by 3 publications

References 44 publications

The Role of Omega-3 in Attenuating Cardiac Remodeling and Heart Failure through the Oxidative Stress and Inflammation Pathways

The Role of Omega-3 in Attenuating Cardiac Remodeling and Heart Failure through the Oxidative Stress and Inflammation Pathways

A simple method to isolate fatty acids and fatty alcohols from wax esters in a wax-ester rich marine oil

Antioxidant Protection against Trastuzumab Cardiotoxicity in Breast Cancer Therapy

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