volume 191, issue 7, P3838-3846 2013
DOI: 10.4049/jimmunol.1300524
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Taslima T. Lina, Irina V. Pinchuk, Jennifer House, Yoshio Yamaoka, David Y. Graham, Ellen J. Beswick, Victor E. Reyes

Abstract: Gastric epithelial cells (GECs) are the primary target for Helicobacter pylori (H. pylori) infection and may act as antigen presenting cells (APC) regulating local T cell responses. We previously reported that H. pylori infection of GECs induces the expression of the T cell co-inhibitory molecule B7-H1 on GECs. This process contributes to the hyporesponsiveness of CD4+ effector T cells and accumulation of T regulatory cells. In the studies presented herein we investigated the impact of H. pylori cytotoxin Cag…

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