Cactus and lupin extracts as prospective anticancer agents compared with utoral drug

Ahmed, Sahar B.; Hamed, Mona; Khiralla, Ghada M.; Mohamed, Aly F.

doi:10.1111/jfbc.13299

Cited by 7 publications

(5 citation statements)

References 32 publications

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“…The mushroom cap contains higher ergosterol content than the stem did at the same growth stage [ 9 ]. Although ergosterol is found in many edible mushrooms, it has been reported to be present in some plant extracts including Chinese hickory, hazelnut, lupin, cactus, and firethorn [ 13 , 14 , 15 , 16 ]. However, it is unclear whether the ergosterol is a real metabolite in these plants or if its presence in plant extracts is due to the contamination of fungi so further study is required.…”

Section: Natural Sources Of Ergosterolmentioning

confidence: 99%

Potential Beneficial Effects and Pharmacological Properties of Ergosterol, a Common Bioactive Compound in Edible Mushrooms

Rangsinth,

Sharika,

Pattarachotanant

et al. 2023

Foods

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Ergosterol is an important sterol commonly found in edible mushrooms, and it has important nutritional value and pharmacological activity. Ergosterol is a provitamin. It has been well established that edible mushrooms are an excellent food source of vitamin D2 because ergosterol is a precursor that is converted to vitamin D2 under ultraviolet radiation. The pharmacological effects of ergosterol, which include antimicrobial, antioxidant, antimicrobial, anticancer, antidiabetic, anti-neurodegenerative, and other activities, have also been reported. This review aims to provide an overview of the available evidence regarding the pharmacological effects of ergosterol and its underlying mechanisms of action. Their potential benefits and applications are also discussed.

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Section: Natural Sources Of Ergosterolmentioning

confidence: 99%

Potential Beneficial Effects and Pharmacological Properties of Ergosterol, a Common Bioactive Compound in Edible Mushrooms

Rangsinth,

Sharika,

Pattarachotanant

et al. 2023

Foods

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“…Apart from these characteristics, protein isolates of lupin cultivars reduced metastasis of cancer cells by inhibiting the activity of MMP-9 enzyme [41]. Ahmed et al narrated a surprising observation that exposed that lupin seed extract showed better apoptotic activity against colorectal cancer CACO-2 cell lines than an existing market drug, 5-fluorouracil [42]. Moreover, natural dietary fibers (also known as prebiotics) have significant roles in alleviating colorectal carcinoma by balancing microbiota present in the large intestine.…”

Section: Discussionmentioning

confidence: 99%

Attenuating Colorectal Cancer Using Nine Cultivars of Australian Lupin Seeds: Apoptosis Induction Triggered by Mitochondrial Reactive Oxygen Species Generation and Caspases-3/7 Activation

Mazumder,

Aktar,

Ramasamy

et al. 2023

Cells

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As Australian lupin cultivars are rich sources of polyphenols, dietary fibers, high-quality proteins, and abundant bioactive compounds with significant antioxidant, antidiabetic, and anticancer activities, this research work is aimed at investigating the colon cancer alleviation activity of nine cultivars of lupin seeds on HCT116 and HT29 colon carcinoma cell lines through anti-proliferation assay, measurement of apoptosis, and identification of the mechanism of apoptosis. Nine cultivars were pre-screened for anti-proliferation of HCT116 and HT29 cells along with consideration of the impact of heat processing on cancer cell viability. Mandelup and Jurien showed significant inhibition of HCT116 cells, whereas the highest inhibition of HT29 cell proliferation was attained by Jurien and Mandelup. Processing decreased the anti-proliferation activity drastically. Lupin cultivars Mandelup, Barlock, and Jurien (dose: 300 μg/mL) induced early and late apoptosis of colon cancer cells in Annexin V-FITC assay. The mechanism of apoptosis was explored, which involves boosting of caspases-3/7 activation and intracellular reactive oxygen species (ROS) generation in HCT116 cells (Mandelup and Barlock) and HT29 cells (Jurien and Mandelup). Thus, the findings showed that lupin cultivars arrest cell cycles by inducing apoptosis of colorectal carcinoma cells triggered by elevated ROS generation and caspases-3/7 activation.

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“…EOs demonstrated to change expression levels of Bcl-2 and Bax genes, leading to the release of cytochrome C into cytosol in human oral epidermoid carcinoma cells 57 . Similarly, a study on human melanoma cells reported that EOs induces DNA damage in cancer cells which is an indicator of apoptosis 58 . Frank et al, 59 studied the action of Boswellia carteri EO (Frankincense oil) in bladder cancer cells and observed modulation of CDKN1A, DEDD2, IER3, IL6, SGK, TNFAIP3 GAD45B, and NUDT2 genes involved in apoptosis.…”

Section: Anticancer Propertiesmentioning

confidence: 94%

Untitled

2021

IJPSR

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Cancer initiates from the transformation of normal living cells into malignant cells via a multistage event that usually advances from a pre-cancerous phase to a malignant tumour. Anti-metastatic drugs or anti-neoplastic drugs prevent and regulate the growth of onco cells. Based on the mode of drugs, the universally anticancer drugs market is categorized into cytotoxic, targeted, and hormonal drugs. The targeted drugs class is further divided into monoclonal antibodies, tyrosine kinase inhibitors, and others. The worldwide anticancer drugs market falls into five regions: North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa. Cancer is considered the second largest cause of death globally and is responsible for an estimated 9.6 million deaths in 2018. Globally, about 1 out of 6 deaths is due to cancer. Approximately 72% of deaths from cancer occur in developed and developing countries. Synthetic drugs and other modes of treatment are pre-existing. Chemotherapy treatments have its own limitations due to their toxic effects on non-targeted tissues and it further leads to health problems. Therefore, the demands for alternative treatments from naturally derived or plant-based anticancer agents are need of the day. Many plant-based anticancer compounds are effective inhibitors against many cancer cell lines, which make them in high demand. The Discovery of anticancer cancer compounds having specificity towards cancer cell lines via apoptotic cell death or derailment of the cell cycle in malignant cells can be considered for clinical trials. This review provides some glimpses of naturallyderived compounds from plants and their mode of action against selected cancer cell lines. INTRODUCTION:From ancient period onwards, herbal medicines were used by the native people and are still the primary source of medicine in most parts of developing and underdeveloped countries.

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Cactus and lupin extracts as prospective anticancer agents compared with utoral drug

Cited by 7 publications

References 32 publications

Potential Beneficial Effects and Pharmacological Properties of Ergosterol, a Common Bioactive Compound in Edible Mushrooms

Potential Beneficial Effects and Pharmacological Properties of Ergosterol, a Common Bioactive Compound in Edible Mushrooms

Attenuating Colorectal Cancer Using Nine Cultivars of Australian Lupin Seeds: Apoptosis Induction Triggered by Mitochondrial Reactive Oxygen Species Generation and Caspases-3/7 Activation

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