Cabergoline for preventing ovarian hyperstimulation syndrome

Prevention of Ovarian Hyperstimulation Syndrome: A Review

“…Tang et al in their Cochrane Review of 230 women in 2 RCTs found cabergoline to be effective in significantly reducing the incidence of moderate OHSS (OR 0.38; 95% CI 0.19–0.78) with no significant effect on clinical pregnancy rate and miscarriage rates. This protective effect, however, did not extend to severe OHSS, possibly due to the number of studies available for comparison [ 84 ]. A recent systemic review by Leitao at el.…”

Prevention of Ovarian Hyperstimulation Syndrome: A Review

“…Tang et al in their Cochrane Review of 230 women in 2 RCTs found cabergoline to be effective in significantly reducing the incidence of moderate OHSS (OR 0.38; 95% CI 0.19–0.78) with no significant effect on clinical pregnancy rate and miscarriage rates. This protective effect, however, did not extend to severe OHSS, possibly due to the number of studies available for comparison [ 84 ]. A recent systemic review by Leitao at el.…”

Does the timing of cabergoline administration impact rates of ovarian hyperstimulation syndrome?

“…Although we found no improvement in reported discomfort or in the rates of severe OHSS with different timings of cabergoline, this may not be the case in hCG-triggered cycles. Given that the only proposed change to the protocol is the timing of cabergoline initiation, and because multiple studies have shown that earlier cabergoline administration has no negative impact on IVF outcomes [7,14,15,17,18], one could argue that there is no risk, and only potential benefit, to administering cabergoline starting at the time of trigger instead of following oocyte collection to reduce the rate of OHSS in moderate and highrisk patients. As demonstrated in the literature, our Trig group did not seem to have any negative outcomes related to oocyte collection and embryo development when compared to the group that received cabergoline at the time of oocyte collection.…”

High Dose Cabergoline in Management of Bilateral Ovarian Hyperstimulation Syndrome: A Case Report

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Prevention of Ovarian Hyperstimulation Syndrome: A Review

“…Tang et al in their Cochrane Review of 230 women in 2 RCTs found cabergoline to be effective in significantly reducing the incidence of moderate OHSS (OR 0.38; 95% CI 0.19–0.78) with no significant effect on clinical pregnancy rate and miscarriage rates. This protective effect, however, did not extend to severe OHSS, possibly due to the number of studies available for comparison [ 84 ]. A recent systemic review by Leitao at el.…”

Does the timing of cabergoline administration impact rates of ovarian hyperstimulation syndrome?

“…Although we found no improvement in reported discomfort or in the rates of severe OHSS with different timings of cabergoline, this may not be the case in hCG-triggered cycles. Given that the only proposed change to the protocol is the timing of cabergoline initiation, and because multiple studies have shown that earlier cabergoline administration has no negative impact on IVF outcomes [7,14,15,17,18], one could argue that there is no risk, and only potential benefit, to administering cabergoline starting at the time of trigger instead of following oocyte collection to reduce the rate of OHSS in moderate and highrisk patients. As demonstrated in the literature, our Trig group did not seem to have any negative outcomes related to oocyte collection and embryo development when compared to the group that received cabergoline at the time of oocyte collection.…”

High Dose Cabergoline in Management of Bilateral Ovarian Hyperstimulation Syndrome: A Case Report

“……”

Prevention of Ovarian Hyperstimulation Syndrome: A Review

“…Tang et al in their Cochrane Review of 230 women in 2 RCTs found cabergoline to be effective in significantly reducing the incidence of moderate OHSS (OR 0.38; 95% CI 0.19–0.78) with no significant effect on clinical pregnancy rate and miscarriage rates. This protective effect, however, did not extend to severe OHSS, possibly due to the number of studies available for comparison [ 84 ]. A recent systemic review by Leitao at el.…”

Does the timing of cabergoline administration impact rates of ovarian hyperstimulation syndrome?

“…Although we found no improvement in reported discomfort or in the rates of severe OHSS with different timings of cabergoline, this may not be the case in hCG-triggered cycles. Given that the only proposed change to the protocol is the timing of cabergoline initiation, and because multiple studies have shown that earlier cabergoline administration has no negative impact on IVF outcomes [7,14,15,17,18], one could argue that there is no risk, and only potential benefit, to administering cabergoline starting at the time of trigger instead of following oocyte collection to reduce the rate of OHSS in moderate and highrisk patients. As demonstrated in the literature, our Trig group did not seem to have any negative outcomes related to oocyte collection and embryo development when compared to the group that received cabergoline at the time of oocyte collection.…”

High Dose Cabergoline in Management of Bilateral Ovarian Hyperstimulation Syndrome: A Case Report

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