CA724 predicts overall survival in locally advanced gastric cancer patients with neoadjuvant chemotherapy

Abstract

Background Serum tumor markers including AFU, AFP, CEA, CA199, CA125 and CA724, are of great importance in the diagnosis, prognostic prediction and recurrence monitoring of gastrointestinal malignancies. However, their significance in gastric cancer (GC) patients with neoadjuvant therapy (NCT) is still uncertain. The aim of this study was to evaluate the predictive value of these six tumor markers in locally advanced GC patients who underwent NCT and curative surgery. Methods In total, 290 locally advanced GC patients who underwent NCT and D2 radical gastrectomy were retrospectively analyzed. Data on their tumor markers before (pre-) and after (post-) NCT and pathological characteristics were extracted from the database of our hospital. The optimal cutoff values of the six tumor markers were calculated by the ROC curve and Youden index. Their predictive significance was analyzed and survival curves for overall survival (OS) were obtained by the Kaplan-Meier method. Associations between categorical variables were explored by the chi-square test or Fisher’s exact test. Multivariate analyses were performed by the Cox regression model. Results Pre- and post-CA199, −CA125 and -CA724 could predict overall survival (all P < 0.05), but only the change (diff-) of CA199 was related to prognosis (P = 0.05). In the multivariable analysis, pre- (P = 0.014) and post-CA724 (P = 0.036) remained significant, though diff-CA724 was not an independent prognostic factor (P = 0.581). In addition, pre- and post-CA199, −CA125 and -CA724 were associated with lymph node metastasis (N- vs N+) and pathological stage (I-II vs III) (all P < 0.05). Moreover, post-CA724 was related to the vascular or lymphatic invasion (P = 0.019), while pre-CA724 was not (P = 0.082). However, AFU, AFP and CEA showed no association with survival (P > 0.05). Conclusions CA724 is an independent factor for prognosis and could be used to predict ypN and ypTNM stage in locally advanced GC patients undergoing NCT and curative resection.

Effect of Apatinib Combined with Seggio on the Expression of Serum AFP and CA724 and Long-Term Survival Rate in Patients with Advanced Gastric Cancer Undergoing Comfortable Nursing Intervention

“…CA724 is a relatively common type of nonspecific tumor marker, which has extremely high sensitivity for non-small cell lung cancer and gastric cancer, and its sensitivity for diagnosing gastric cancer is about 60% [ 21 , 22 ]. AFP is a commonly used tumor serum marker, and its level is low in healthy adult serum, but its level is increased in hepatocellular carcinoma [ 23 ].…”

Controlling Nutritional Status (CONUT) Predicts Survival in Gastric Cancer Patients With Immune Checkpoint Inhibitor (PD-1/PD-L1) Outcomes

“…Moreover, patients with a high CONUT had shorter PFS and OS than those with low CONUT, especially in patients with high CA724 value. Tong Y and others also found that CA724 was an independent factor for prognosis and could be used to TNM stage in locally advanced gastric cancer patients who received neoadjuvant chemotherapy and curative resection (Tong et al, 2021).…”

The Influence of Heavy Metals on Gastric Tumorigenesis

“…Therefore, heavy metals may contribute to the MSI status and HER2 gene expression, but the pathogenic mechanism needs to be further studied. Besides that, the level of serum tumor biomarkers plays an important role in the progression of GC [ 55 ]. A previous study indicated that CA72-4 was correlated with the TNM stage in GC patients [ 56 ].…”