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“…An association between PGHS-2 regulation and calcium (37)(38)(39), as well as PGHS-2 and cAMP (40 -42), has been reported before in other systems. We have previously shown that nonreceptor-mediated elevation of cAMP can stimulate expression of PGHS-2 in pregnant human myometrium (24).…”
Section: Discussionmentioning
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“…An association between PGHS-2 regulation and calcium (37)(38)(39), as well as PGHS-2 and cAMP (40 -42), has been reported before in other systems. We have previously shown that nonreceptor-mediated elevation of cAMP can stimulate expression of PGHS-2 in pregnant human myometrium (24).…”
Section: Discussionmentioning
“…Willott et al (2002) noted that PLA 2 activity in M. sexta hemocytes is Ca 11 -independent, making it unlikely that the needed Ca 11 acts to increase eicosanoid biosynthesis via activating PLA 2 activity. Nonetheless, Ca 11 induces expression of one of the COX genes, COX-2, and increases PGE 2 production in mammalian osteoblasts (Choudhary et al, 2004) and in fibroblasts (Ogata et al, 2006). Hence, the Ca 11 required for hemocyte spreading may act through increasing production of PGE 2 , which increases hemocyte spreading in a dose-dependent manner in our studies.…”
Section: Discussionmentioning
“…9 Many cell types respond to Ca 2ϩ o via the G-protein-linked calcium-sensing receptor (CaSR), 10 including cells from endocrine organs, 11 bone (osteoblasts and osteoclasts), 10 brain, 10 intestine, 10 kidney, 10 skin, 12 ovary, 13 as well as fibroblasts. 14 CaSR is also expressed by normal hematopoietic cells (including red cell and platelet precursors, monocytes, macrophages, 15 and hematopoietic stem cells 16 ) and myeloma cells and cell lines. 17 Despite the evidence for a CaSR on malignant B cells, normal lymphocytes are not known to express CaSR, 15,17 and it is not clear if B cells can respond directly to Ca 2ϩ o .…”
Section: Introductionmentioning