Ca2+ and Mg2+ bind tetracycline with distinct stoichiometries and linked deprotonation

Jin, Lihua; Amaya-Mazo, Xylenia; Apel, Matthew; Sankisa, Sudha S.; Johnson, Elissa A.; Zbyszynska, Monika A.; Han, Aaron C.

doi:10.1016/j.bpc.2007.04.005

Cited by 94 publications

(56 citation statements)

References 41 publications

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“…It is also possible that some may be complexed with other species in water. For example, tetracycline can complex with Ca ++ in water (Jin et al 2007). …”

Section: Resultsmentioning

confidence: 98%

Presence of steroid hormones and antibiotics in surface water of agricultural, suburban and mixed-use areas

Velicu

Suri

2008

Environ Monit Assess

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The occurrence of pharmaceutically active chemicals (PACs) in the natural aquatic environment is recognized as an emerging issue due to the potential adverse effects these compounds pose to aquatic life and humans. This study presents the monitoring of two major categories of PACs in surface water: steroid hormones and antibiotics. Surface water samples were collected in the fall season from 21 locations in suburban (4), agricultural (5) and mixed (12) use suburban and agricultural areas. The water samples collected were analyzed using GC/MS for aqueous concentration of eleven steroid hormones: six natural (17alpha-estradiol, 17beta-estradiol, estrone, estriol, 17alpha-dihydroequilin, progesterone) and five synthetic (gestodene, norgestrel, levonorgestrel, medrogestone, trimegestone). In addition, 12 antibiotics (oxytetracycline, chlorotetracycline, tetracycline, sulfamethoxazole, sulfamethazine, trimethoprim, lincomycin, norfloxacin, ofloxacin, roxithromycin, erythromycin, tylosin tartrate) were analyzed using LC/MS. Steroid hormones detected in surface water were: 17alpha-estradiol, 17beta-estradiol, 17alpha-dihydroequilin, estriol, estrone, progesterone and trimegestone. Estrone had the highest detection frequency of >90% with concentrations ranging from 0.6 to 2.6 ng/l. The second most frequently detected estrogen was estriol (>80%) with concentrations ranging from 0.8 to 19 ng/l. The detection frequency varied at different sampling locations. No antibiotics were detected in the 21 streams sampled. This study aims to give a better understanding on the presence, fate and transport of PACs derived from humans and animals.

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“…It is also possible that some may be complexed with other species in water. For example, tetracycline can complex with Ca ++ in water (Jin et al 2007). …”

Section: Resultsmentioning

confidence: 98%

Presence of steroid hormones and antibiotics in surface water of agricultural, suburban and mixed-use areas

Velicu

Suri

2008

Environ Monit Assess

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“…The third deprotonation step (pK 3 = 9.6) occurs at NH4, generating a dianion. Finally, fourth deprotonation takes place at OH10 (pK 4 = 12) [17][18][19]. Thus, TC has a high possibility for forming chelation complexes with metal ions.…”

Section: Effect Of Edtamentioning

confidence: 98%

“…However, as mentioned earlier, honey consists of no fat and few proteins, therefore the sample preparation is not needed. However, honey has metal ions such as calcium, iron, magnesium, potassium, sodium and zinc ion [16] so it is necessary to consider the high potential for forming chelating complexes between TC and these metal ions [17,18].…”

Section: Effect Of Edtamentioning

confidence: 99%

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Quantitative detection of tetracycline residues in honey by a simple sensitive immunoassay

Jeon

Paeng

2008

Analytica Chimica Acta

120

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“…and Mg 2+ , and the complexation of tetracycline with Ca 2+ and Mg 2+ in the aqueous phase might cause the decreased adsorption (Figueroa and Mackay 2005;Jin et al 2007;Tanis et al 2008). Additionally, the adsorption competition between positively charged quaternary ammonium functional group of tetracycline and divalent cations (Ca 2+ and Mg 2+ ) for the cation exchange sites of adsorbent surface (e.g., carboxyl groups on extracellular polymeric substance of AS) will also decrease tetracycline adsorption (Liu et al 2010;Pils and Laird 2007;Sun et al 2009;Sun et al 2010;Tanis et al 2008) , it can be found that the ability of Ca 2+ to decrease tetracycline adsorption was weaker than that of Mg 2+ given the same mole concentration.…”

Section: +mentioning

confidence: 99%

Experimental and Theoretical Approaches for the Surface Interaction between Copper and Activated Sludge Microorganisms at Molecular Scale

Sánchez¹

2016

Environmental Engineering and Activated Sludge Processes

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Understanding the removal mechanisms and kinetics of trace tetracycline by activated sludge is critical to both evaluation of tetracycline elimination in sewage treatment plants and risk assessment/management of tetracycline released to soil environment due to the application of biosolids as fertilizer. Adsorption is found to be the primary removal mechanism while biodegradation, volatilization, and hydrolysis can be ignored in this study. Adsorption kinetics was well described by pseudo-second-order model. Faster adsorption rate (k 2 02.04×10 −2 gmin −1 μg −1 ) and greater adsorption capacity (q e 038.8 μg g −1 ) were found in activated sludge treating freshwater sewage. Different adsorption rate and adsorption capacity resulted from chemical properties of sewage matrix rather than activated sludge surface characteristics. The decrease of tetracycline adsorption in saline sewage was mainly due to Mg 2+ which significantly reduced adsorption distribution coefficient (K d ) from 12,990 ± 260 to 4,690 ± 180 L kg −1 .Species-specific adsorption distribution coefficients followed the order of. Contribution of zwitterionic tetracycline to the overall adsorption was >90 % in the actual pH range in aeration tank. Adsorption of tetracycline in a wide range of temperature (10 to 35°C) followed the Freundlich adsorption isotherm well.

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Ca2+ and Mg2+ bind tetracycline with distinct stoichiometries and linked deprotonation

Cited by 94 publications

References 41 publications

Presence of steroid hormones and antibiotics in surface water of agricultural, suburban and mixed-use areas

Presence of steroid hormones and antibiotics in surface water of agricultural, suburban and mixed-use areas

Quantitative detection of tetracycline residues in honey by a simple sensitive immunoassay

Experimental and Theoretical Approaches for the Surface Interaction between Copper and Activated Sludge Microorganisms at Molecular Scale

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