CA 19-9 Pancreatic Tumor Marker Fluorescence Immunosensing Detection via Immobilized Carbon Quantum Dots Conjugated Gold Nanocomposite

Alarfaj, Nawal A.; El‐Tohamy, Maha F.; Oraby, Hesham F.

doi:10.3390/ijms19041162

Cited by 132 publications

(46 citation statements)

References 45 publications

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“…Molecules 2020, 25, combining with other types of nanoparticles [21,[36][37][38][39]. Application of heteroatoms, such as nitrogen and sulfur, helps to create new surface states which results in enhanced photoluminescence (PL) properties, especially increased photostability and quantum yield [10,24,35].…”

Section: Fouriertransform Infrared Spectroscopy (Ftir) and Nuclear Mamentioning

confidence: 99%

“…The parameter is almost twice lower for water, acetone, and ACN, and a very small shift of the peak maximum is noticeable. Thus, it can be concluded that the nanomaterials may be applied in various applications and media of various hydrophility, which is important in the field of diagnostics, and from this point of view is a desirable feature [17][18][19][20][21][22][23]. Our previous research showed that the bottom-up CQD synthesis routes with in situ doping enables the preparation of nanodots with the maximal QY up to 13%, which may be insufficient in some applications [44].…”

Section: Spectroscopic Properties Studymentioning

confidence: 99%

“…A promising tool are quantum dots (QDs) which can be described as objects of the size below 10 nm with unique properties [1][2][3][4]. Since their development, they have been successfully used in optoelectronics [1], food packaging [5], metals detection [6][7][8], bioimaging [9][10][11][12][13][14], photocatalysis [15,16], sensing [17][18][19][20][21][22][23], cell labelling [24], or fluorescent inks and others [25,26]. The first-generation quantum dots are semiconductors of crystalline structure [3].…”

Section: Introductionmentioning

confidence: 99%

“…Neutral or negatively-charged macromolecules are used for the CQDs' surface modification with therapeutic designation since they prevent protein adsorption, resulting in prolonged circulation in blood [24]. There are also numerous scientific reports regarding other ways of carbon quantum dot functionalization, including doping and combining with other types of nanoparticles [21,[36][37][38][39]. Application of heteroatoms, such as nitrogen and sulfur, helps to create new surface states which results in enhanced photoluminescence (PL) properties, especially Sample Availability: Samples of the compounds are available from the authors on the request.…”

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confidence: 99%

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Smart, Tunable CQDs with Antioxidant Properties for Biomedical Applications—Ecofriendly Synthesis and Characterization

et al. 2020

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Carbon quantum dots (CQDs) are nanoobjects of a size below 10 nm. Due to their favorable features, such as tunable luminescence, unique optical properties, water solubility, and lack of cytotoxicity, they are willingly applied in biomedicine. They can be obtained via bottom-up and top-down methods. However, to increase their quantum yield they must undergo post-processing. The aim of the following research was to obtain a new type of CQDs modified with a rhodamine b derivative to enhance their fluorescence performance without biocompability deterioration. For their preparation glucose was used as a precursor and four different carbonizing agents which affected semi-and final products luminescence properties. The ready nanomaterials were investigated over their chemical structure by FTIR and NMR, whereas morphology was investigated by the TEM method. Their optical properties were determined by UV-VIS spectroscopy. Fluorescence behavior, photo-and pH-stability, as well as solvatochromism showed their applicability in various biomedical applications due to the controlled properties. The samples exhibited excellent antioxidant activity and lack of cytotoxicity on L929 mouse fibroblasts. The results showed that proposed strategy enables preparation of the superior nanomaterials with outstanding luminescence properties such as quantum yield up to 17% which can be successfully applied in cell labelling, bioimaging, and theranostics.Molecules 2020, 25, 736 2 of 18 can release cadmium ions leading to cell death. Importantly, it occurred that quantum dots may undergo certain modifications resulting in the change of their surface or chemical structure [27,28]. Finally, their preparation is expensive. Therefore, there was a need for a novel type of quantum dots which would be suitable for biomedical applications. In 2004, a new type of carbon-based materials was accidentally obtained during nanotube purification [29]. Until then, numerous types of carbon quantum dots (CQDs) have been obtained with various possible applications due to their very attractive properties, such as luminesce, good water solubility, high photostability, resistance to photobleaching or photoblinking, possibility, chemical inertness and, finally, lack of toxicity and biocompability [1][2][3]. Furthermore, CQDs' region of photoluminescence is very broad, starting in the ultraviolet and ending in the near-infrared. Although, until now, the luminescence behavior of carbon nanodots is still not fully clear, it is believed that crucial role plays two factors, namely, that the quantum size is below 10 nm and surface defects which may act as excitation energy traps. Interestingly, CQDs can successfully act as both electron donors and acceptors [2][3][4].CQDs can be prepared from various resources, such as peels (mango, orange, banana, pineapple, onion, seaweed etc.), meat, grains, nuts, or vegetable by-products, which makes them a low-cost material [30,31]. Currently, these nanomaterials are widely applied in drug delivery, gene delivery, biosensing, bioimag...

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Section: Fouriertransform Infrared Spectroscopy (Ftir) and Nuclear Mamentioning

confidence: 99%

Section: Spectroscopic Properties Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Smart, Tunable CQDs with Antioxidant Properties for Biomedical Applications—Ecofriendly Synthesis and Characterization

et al. 2020

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“…Such a phenomenon is called the quantum confinement effect [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. Quantum dots may be applied in bioimaging and biodiagnostics [ 16 , 17 , 18 , 19 ]. Various types of these nanomaterials were successfully used for this purpose such as CdS, CdSe, CdTe, MoS 2 or PbS.…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis of Surface-Modified Carbon Quantum Dots (CQDs) for Biosensing and Bioimaging

et al. 2020

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Recently, fluorescent probes became one of the most efficient tools for biosensing and bioimaging. Special attention is focused on carbon quantum dots (CQDs), which are characterized by the water solubility and lack of cytotoxicity. Moreover, they exhibit higher photostability comparing to traditional organic dyes. Currently, there is a great need for the novel, luminescent nanomaterials with tunable properties enabling fast and effective analysis of the biological samples. In this article, we propose a new, ecofriendly bottom-up synthesis approach for intelligent, surface-modified nanodots preparation using bioproducts as a raw material. Obtained nanomaterials were characterized over their morphology, chemical structure and switchable luminescence. Their possible use as a nanodevice for medicine was investigated. Finally, the products were confirmed to be non-toxic to fibroblasts and capable of cell imaging.

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Modified Absorption and Emission Properties Leading to Intriguing Applications in Plasmonic–Excitonic Nanostructures

Kumar

Nisika

Kumar

2020

Advanced Optical Materials

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years, great advances have been made to grow various shaped semiconductor nanocrystals (SNCs) like quantum dots, [7] nanowires, [8] nanorods (NR), [9] and other advanced shaped nanostructures, [10-12] with great precision. However, these semiconductor nanostructures have small extinction cross-sections (even smaller than geometric cross-section), leading to limited absorbance and emission quantum yields. This hinders the progress of semiconductor nanostructures in several areas ranging from clean energy production to various sensing applications. Among many promising solutions, integrating plasmonic nanoparticles (PNPs) with semiconductor nanostructures emerges as the most prominent way to alleviate aforementioned issue. The PNPs have greater extinction cross-section than SNCs (even greater than geometric cross-section), owing to light absorption and scattering by collective and coherent electron oscillations. [13,14] Moreover, these coherent oscillations can couple with electromagnetic wavelengths far greater than particle size, enabling them to guide light to subwavelength scales, thus overcoming diffraction limit. [15] Besides this, proper control over size and shape of plasmonic nanostructures enables engineering of their intrinsic properties to meet the criteria of required application. [16] For instance, by changing the aspect ratio (length to diameter ratio) of nanorods, one can cover wide spectral regions ranging from visible to near-infrared (NIR) regimes. [17] Thus, the integration of plasmonic and semiconductor nanostructures to obtain greater extinction cross-sections and modified properties in these hybrid nanostructures has received great attention from the research community over the past years. The properties of these hybrid nanostructures can be very different from the two nanoconstituents (metal and semiconductor nanostructures), owing to plasmon-exciton interactions. [18-20] Various configurations of metal/semiconductor nanostructures have been synthesized like metallic core/semiconductor shell, [21] semiconductor NR/metal nanoparticles (MNPs), [22] Janus metal/ semiconductor nanostructures, [23] and many others have been reported, [24-26] with varying absorption and emissive properties, targeting high performance applications. The energy transfer between metal-semiconductor nanostructures resulting from integration of PNPs and SNCs Hybrid nanostructures composed of metal and semiconducting nanocrystals have drawn tremendous attention owing to their extraordinary absorption and emission properties. The energy transfer in metal-semiconductor hybrids as a result of synergetic plasmon-exciton interactions leads to numerous applications in the field of solar energy harvesting, photocatalytic reactions, imaging, photonics, sensing, and many more. Various breakthroughs in advanced characterization techniques over the past decade have disclosed several factors affecting the energy transfer processes leading to modified absorption and emission properties in metal-semiconductor hybrids. Herein, various ...

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CA 19-9 Pancreatic Tumor Marker Fluorescence Immunosensing Detection via Immobilized Carbon Quantum Dots Conjugated Gold Nanocomposite

Cited by 132 publications

References 45 publications

Smart, Tunable CQDs with Antioxidant Properties for Biomedical Applications—Ecofriendly Synthesis and Characterization

Smart, Tunable CQDs with Antioxidant Properties for Biomedical Applications—Ecofriendly Synthesis and Characterization

Facile Synthesis of Surface-Modified Carbon Quantum Dots (CQDs) for Biosensing and Bioimaging

Modified Absorption and Emission Properties Leading to Intriguing Applications in Plasmonic–Excitonic Nanostructures

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