volume 2, issue 8, PS378 2007
DOI: 10.1097/01.jto.0000283228.79014.7b
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Abstract: S378remains unclear. We performed DNMT1 promoter luciferase assay and found that wild type p53 could negatively regulate the DNMT1 promoter, whereas mutant p53 could activate DNMT1 promoter activity. The physical binding of wild type p53 and mutant p53 to DNMT1 promoters was identified by chromatin immunoprecipitation. These data suggest that deregulation of DNMTs is associated with the loss of transcriptional repression of p53. The p53 mutation results in overexpression of DNMT1 and hypermethyaltion of target…

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