2020
DOI: 10.3389/fimmu.2020.00477
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Abstract: Neuropathic pain is among the most debilitating forms of chronic pain. Studies have suggested that chronic pain pathogenesis involves neuroimmune interactions and blood-spinal cord barrier (BSCB) disruption. However, the underlying mechanisms are poorly understood. We modeled neuropathic pain in rats by inducing chronic constriction injury (CCI) of the sciatic nerve and analyzed the effects on C-X-C motif chemokine 10 (CXCL10)/CXCR3 activation, BSCB permeability, and immune cell migration from the circulation … Show more

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Cited by 23 publications
(13 citation statements)
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“…Neuropathic pain can cause central sensitization (32,33), and its mechanisms include cytokine and chemokine release by spinal cord glial cells (19,34,35). Increasing evidence indicates that chemokine signals are crucial players in neuropathic pain (20,34,(36)(37)(38). CXCL10 promotes neuropathic pain by increasing the permeability of the blood-spinal cord barrier (20).…”
Section: Discussionmentioning
confidence: 99%
“…Neuropathic pain can cause central sensitization (32,33), and its mechanisms include cytokine and chemokine release by spinal cord glial cells (19,34,35). Increasing evidence indicates that chemokine signals are crucial players in neuropathic pain (20,34,(36)(37)(38). CXCL10 promotes neuropathic pain by increasing the permeability of the blood-spinal cord barrier (20).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, it was found that astrocyte sigma-1 receptors modulate Cx43 expression, leading to the induction of mechanical allodynia in the SC injured mice [ 63 ]. Moreover, the data suggest that the astrocytic Cx43 hemichannels are negatively involved in the remyelination process by favoring local inflammation [ 64 ]. Decrock et al described the importance of Cx channels in the interaction between neuronal, glial, and vascular compartments in the CNS.…”
Section: Discussionmentioning
confidence: 99%
“…IL9 is a pleiotropic cytokine, which affects the activity of multiple cell types in the immune compartment and in the CNS [32]. Monocyte chemoattractant protein-1 (MCP-1) is a strong candidate for mediating chemotaxis of monocytes to the injured nervous system, and monocyte recruitment and myelin removal are delayed following spinal cord injury in mice genetically deleted for the main MCP-1 receptor [33]. MIP-1 are a potent chemoattractants not only for inflammatory cells, but they also promotes healing and homeostasis in several tissues [34].…”
Section: Discussionmentioning
confidence: 99%