C-Type Lectin Receptors in Antiviral Immunity and Viral Escape

Bermejo‐Jambrina, Marta; Eder, Julia; Helgers, Leanne C.; Hertoghs, Nina; Nijmeijer, Bernadien M.; Stunnenberg, Melissa; Geijtenbeek, Teunis B. H.

doi:10.3389/fimmu.2018.00590

Cited by 138 publications

(133 citation statements)

References 151 publications

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“…Although such additional receptors may not promote any fusion step, they can drive viral internalization through endocytic processes or simply by viral adhesion to the host cell, accumulation of viral particles on the cell surface and finally engagement with the primary receptor followed by the fusion event. Different types of attachment factors can be found on the host cell surface: either glycans, such as heparan-sulfate, glycolipids or protein N-glycans, often targeted by envelope viral protein with lectin-like properties (Dimitrov, 2004), or immune lectin-type receptors including CLRs and Siglecs (Bermejo-Jambrina et al, 2018;Perez-Zsolt et al, 2019). CLRs primary role is to sense the presence of pathogen through recognition of specific non-self glycans.…”

Section: Discussionmentioning

confidence: 99%

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

Thépaut

Luczkowiak

Vivès

et al. 2020

Preprint

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The efficient spread of SARS-CoV-2 resulted in a pandemic that is unique in modern history. Despite early identification of ACE2 as the receptor for viral spike protein, much remains to be understood about the molecular events behind viral dissemination. We evaluated the contribution of C-type lectin receptors (CLRS) of antigen-presenting cells, widely present in air mucosa and lung tissue. DC-SIGN, L-SIGN, Langerin and MGL bind to diverse glycans of the spike using multiple interaction areas. Using pseudovirus and cells derived from monocytes or T-lymphocytes, we demonstrate that while virus capture by the CLRs examined does not allow direct cell infection, DC/L-SIGN, among these receptors, promote virus transfer to permissive ACE2+ cells. A glycomimetic compound designed against DC-SIGN, enable inhibition of this process. Thus, we described a mechanism potentiating viral capture and spreading of infection. Early involvement of APCs opens new avenues for understanding and treating the imbalanced innate immune response observed in COVID-19 pathogenesis.

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Section: Discussionmentioning

confidence: 99%

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

Thépaut

Luczkowiak

Vivès

et al. 2020

Preprint

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“…Once HIV-1 enters the host, even in a very low concentration, it will be immediately captured by DCs via DC-SIGN [41]. This case is different from DC-SIGN mediated "eat" and "digest", instead DC-SIGN can enrich the virus on the DCs surface and helps to retain HIV-1 infectivity [232]. Afterward, DCs carry the enriched HIV-1 to the lymphoid organs which rich in CD4 + T cells, and finally HIV-1 is enriched and transmitted to target cells [233][234][235].…”

Section: Host Lectinsmentioning

confidence: 99%

Role of Protein Glycosylation in Host-Pathogen Interaction

Lin

Xue

Liao

et al. 2020

Cells

116

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Host-pathogen interactions are fundamental to our understanding of infectious diseases. Protein glycosylation is one kind of common post-translational modification, forming glycoproteins and modulating numerous important biological processes. It also occurs in host-pathogen interaction, affecting host resistance or pathogen virulence often because glycans regulate protein conformation, activity, and stability, etc. This review summarizes various roles of different glycoproteins during the interaction, which include: host glycoproteins prevent pathogens as barriers; pathogen glycoproteins promote pathogens to attack host proteins as weapons; pathogens glycosylate proteins of the host to enhance virulence; and hosts sense pathogen glycoproteins to induce resistance. In addition, this review also intends to summarize the roles of lectin (a class of protein entangled with glycoprotein) in host-pathogen interactions, including bacterial adhesins, viral lectins or host lectins. Although these studies show the importance of protein glycosylation in host-pathogen interaction, much remains to be discovered about the interaction mechanism.

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“…They are transmembrane receptors, with an immunoreceptor tyrosine-based activation motif (ITAM) or an immunoreceptor tyrosine-based inhibition motif (ITIM), that are able to induce a pro-inflammatory response or modulate it through a crosstalk with other PRRs such as TLRs. CLRs play a crucial role in maintaining immune homeostasis against pathogens and in mounting a pro-inflammatory and/or antiviral response (80)(81)(82). Alterations of CLRs have been implicated in different pathological conditions, including gastrointestinal cancers, autoimmune disorders, or allergies (82).…”

Section: Cholangiocyte Immunobiologymentioning

confidence: 99%

Innate Immunity and Pathogenesis of Biliary Atresia

et al. 2020

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Biliary atresia (BA) is a devastating fibro-inflammatory disease characterized by the obstruction of extrahepatic and intrahepatic bile ducts in infants that can have fatal consequences, when not treated in a timely manner. It is the most common indication of pediatric liver transplantation worldwide and the development of new therapies, to alleviate the need of surgical intervention, has been hindered due to its complexity and lack of understanding of the disease pathogenesis. For that reason, significant efforts have been made toward the development of experimental models and strategies to understand the etiology and disease mechanisms and to identify novel therapeutic targets. The only characterized model of BA, using a Rhesus Rotavirus Type A infection of newborn BALB/c mice, has enabled the identification of key cellular and molecular targets involved in epithelial injury and duct obstruction. However, the establishment of an unleashed chronic inflammation followed by a progressive pathological wound healing process remains poorly understood. Like T cells, macrophages can adopt different functional programs [pro-inflammatory (M1) and resolutive (M2) macrophages] and influence the surrounding cytokine environment and the cell response to injury. In this review, we provide an overview of the immunopathogenesis of BA, discuss the implication of innate immunity in the disease pathogenesis and highlight their suitability as therapeutic targets.

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C-Type Lectin Receptors in Antiviral Immunity and Viral Escape

Cited by 138 publications

References 151 publications

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

Role of Protein Glycosylation in Host-Pathogen Interaction

Innate Immunity and Pathogenesis of Biliary Atresia

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