C-reactive protein levels associated with COVID-19 outcomes in the United States

Abstract

Context COVID-19 caused a worldwide pandemic, and there are still many uncertainties about the disease. C-reactive protein (CRP) levels could be utilized as a prognosticator for disease severity in COVID-19 patients. Objectives This study aims to determine whether CRP levels are correlated with COVID-19 patient outcomes and length of stay (LoS). Methods A retrospective cohort study was conducted utilizing data obtained between March and May 2020. Data were collected by abstracting past medical records through electronic medical records at 10 hospitals within CommonSpirit Health. Patients were included if they had a positive COVID-19 test from a nasopharyngeal swab sample, and if they were admitted and then discharged alive or had in-hospital mortality and were ≥18 years. A total of 541 patients had CRP levels measured and were included in this report. Patient outcome and LoS were the endpoints measured. Results The 541 patients had their CRP levels measured, as well as the demographic and clinical data required for analysis. While controlling for body mass index (BMI), number of comorbidities, and age, the first CRP was significantly predictive of mortality (p<0.001). The odds ratio for first CRP indicates that for each one-unit increase in CRP, the odds of death increased by 0.007. For LoS, the first CRP was a significant predictor (p<0.001), along with age (p=0.002). The number of comorbidities also predicted LoS (p=0.007), but BMI did not. The coefficient for the first CRP indicates that, for each one-unit increase in CRP, LoS increased 0.003 days. Conclusions The results indicate that there is a positive correlation between the CRP levels of COVID-19 patients and their respective outcomes with regard to death and LoS.

The prognostic value of biomarker levels and chest imaging in patients with COVID-19 presenting to the emergency department

“…In our study, CRP was found to be marginally associated with mortality in patients with COVID-19 with an OR of 1.01. This was similar to what was found in 2 other studies where CRP had an OR of 1.007 (95% CI = 1.004–1.010, p = 0.0001 and 95% CI = 1.005–1.009, p < 0.001) ( 45 , 46 ).…”

Hybrid Bayesian Network-Based Modeling: COVID-19-Pneumonia Case

“…Most indicators match for these two graphs, which demonstrates the stability and significance of the discovered relationships in the two graphs. The graph in Figure 6 shows a link between the length of stay and C-reactive protein (its link with COVID-19 outcome has been proven in many studies [ 36 ]) on the one hand and PLT (which influences COVID-19-related length of stay as described in [ 37 ]) on the other hand.…”

Lactate dehydrogenase and C-reactive protein as predictors of severity and prognosis in corona virus disease 2019 (COVID-19) in Iraqi patients

“…In this study 56% of patient had comorbidities for covid 19 such as hypertension, diabetes, ischemic heart disease, chronic kidney and liver disease .COVID-19 patients with pre-existing comorbidities had a higher likelihood of death. These findings could potentially help doctors to sort out the most susceptible COVID-19 patients by comorbidities, take precautionary measures which could potentially reduce the number of fatalities in COVID-19 (20) .In the early stage of COVID-19 CRP levels were positively correlated with lung lesions and could reflect disease severity (21) and there is a positive correlation between the CRP levels of COVID-19 patients and their respective outcomes with regard to death (22). High CRP levels in COVID-19 patients are strongly associated with the prognosis of COVID-19 which must be employed within the clinical practice to guide COVID-19 disease severity (23) .A recent study showed that about 7.7% of non-severe COVID-19 patients were progressed to severe disease courses after hospitalization (24) .In this study when we investigated the effect of initial crp level on severity and complication and prognosis of patients with laboratory-confirmed COVID-19 and we found that found that CRP levels are predictive factor of complication development ,and independent of factors such as gender ,severity and comorbidities ,CRP increase in complicated patients with COVID 19 infection (p value 0.018)which is significant.…”