C-reactive protein in schoolchildren and its relation to adiposity, physical activity, aerobic fitness and habitual diet

Thomas, Non E.; Baker, Julien S.; Graham, Michael R.; Cooper, Stephen‐Mark; Davies, Bruce

doi:10.1136/bjsm.2007.043604

Cited by 38 publications

(42 citation statements)

References 35 publications

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“…Although no significant association of CRP with gender and age was observed, there was a higher prevalence of high CRP among females and adolescents,which corroborateda study conducted with 164 adolescents in two schools in England that showed no significant differences in the CRP concentrations among boys and girls 21 .…”

Section: Discussionsupporting

confidence: 76%

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C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

Cardoso

Carvalho

et al. 2014

Rev. Nutr.

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OBJECTIVE: To investigate the relationship between ultrasensitive C-reactive protein and cardiometabolic risk factors in overweight or obese childrenand adolescents. METHODS: Cross-sectional study conducted at the Center for Childhood Obesity in the period from April 2009 to April 2010, involving 185 overweight children and adolescents aged 2 to 18 years. Measures of ultrasensitive C-reactive protein according to age, nutritional status, gender, race, cardiometabolic risk factors (waist circumference, lipid profile, impaired fasting glucose, high blood pressure and presence of insulin resistance) were compared through the Chi-square test and analysis of variance. All analyses were performed using the Statistical Package for the Social Sciences software version 17.0, adopting a significance level of 5%. RESULTS: Altered high-density lipoprotein was the most frequent cardiometabolic risk factor, and there was a significant association between altered ultrasensitive C-reactive protein values and severe obesity (p=0.005), high waist circumference (p<0.001), hypertriglyceridemia (p=0.037) and insulin resistance (p=0.002), as well as significantly higher body mass index (p=0.000), waist circumference (p=0.001), insulin (p=0.005) and index of glucose homeostasis values(p=0.005). CONCLUSION: High prevalence of altered ultrasensitive C-reactive protein and significant association with severe obesity, waist circumference, hypertriglyceridemia and insulin resistance were observed.

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Section: Discussionsupporting

confidence: 76%

“…At individual level; however, the correlation between BMI and cardiovascular disease is not always simple due in part to differences in the fatty tissue deposits, overall rate of adipocyte dysfunction, tissue vascularity, and local level of inflammation 21 .…”

Section: Discussionmentioning

confidence: 99%

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

Cardoso

Carvalho

et al. 2014

Rev. Nutr.

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“…Several inves tigations have compared the effect of dietary carbohydrate on concentra tion of inflammatory markers. One study found no association between diet compositions and serum CRP [6]; another found that a lowcarbohydrate diet increased serum CRP [16]. In a third study, the effect of lowcarbohy drate diet on CRP concentration was consistent with our own observations [17].…”

Section: Fbs = Fasting Blood Sugar; Tc = Total Cholesterol; Hdl-c = Hsupporting

confidence: 79%

“…Several of the drugs used to treat hyperglycaemia and dyslip daemia can reduce concentrations of inflammatory markers [1]. Recently, some studies have shown inflam matory markers are associated with lifestyle factors including diet, adipose tissue, physical activity and cigarette smoking [6,7] and have suggested lifestyle modification may reduce the risk of inflammation and CVD [8]. Accordingly, this study was aimed at investigating the association between modifiable lifestyle factors with inflam matory markers in patients with meta bolic syndrome in order to gain a better understanding of the factors that cause this phenomenon and prevention of CVD in these individuals.…”

Section: Introductionmentioning

confidence: 99%

735 Association between modifiable lifestyle factors and inflammatory markers in patients with metabolic syndrome

Golzarand¹,

Toolabi²,

Ebrahimi-Mameghani³

et al. 2012

East Mediterr Health J

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There is accumulating evidence suggesting that inflammation is the bridging link between cardiovascular disease and metabolic syndrome. Recent studies have shown a relationship between inflammatory markers and modifiable lifestyle factors including fitness, diet, exercise and smoking. We carried out a cross-sectional study of 195 patients with metabolic syndrome. Data on nutritional intake, physical activity level and smoking habits were collected through a questionnaire. Weight and body composition were determined and C-reactive protein and interluekin-6 concentrations were measured. C-reactive protein level had a significant association with body mass index (r = 0.18), adiposity (r = 0.23), smoking (r = 0.20), carbohydrate intake (r = 0.19) and saturated fatty acid (r = 0.20). Interluekin-6 concentration was significantly correlated with dietary carbohydrate (r = 0.15), saturated fatty acid (r = 0.15) and glycaemic load (r = 0.15). No association was observed between physical activity level and inflammatory markers.

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“…Nevertheless, once body fat was entered in the regression models, no associations with cardiovascular fitness or physical activity and either of the inflammatory markers measured were observed (74) . Similarly, no associations were found between cardiorespiratory fitness or selfreported physical activity and CRP in 12-year-old healthy Welsh children (75) . CRP, C3 and ceruloplasmin (but not C4) were negatively associated with muscle strength after controlling for sex, age, pubertal status, weight, height, socioeconomic status and cardiorespiratory fitness, but did not remain when adjusting body fat.…”

Section: Middle-aged Younger Adults and Childrenmentioning

confidence: 90%

Physical activity, exercise and low-grade systemic inflammation

et al. 2010

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Prospective studies have shown that chronic low-grade inflammation may contribute to the pathogenesis of the most common chronic diseases and in particular CVD. Obesity has repeatedly been associated with moderately raised levels of inflammation, and this observation has led to the view that obesity is characterised by a state of chronic low-grade inflammation. There is now great interest in elucidating how physical activity and exercise modulate inflammation. This review summarises the current research addressing the influence of physical activity and exercise in mitigating the risks of obesity and diseases such as type-II diabetes and CVD, through its action on the low-grade inflammatory state. Most research on this topic hypothesised that the association between physical activity and inflammatory markers is independent of fatness, but very few studies have proven this. Given that physical activity and obesity are often inversely related, it is not clear as to whether the anti-inflammatory health benefits of a physically active lifestyle are due to exercise per se or result from favourable changes in the body composition.

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C-reactive protein in schoolchildren and its relation to adiposity, physical activity, aerobic fitness and habitual diet

Cited by 38 publications

References 35 publications

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

735 Association between modifiable lifestyle factors and inflammatory markers in patients with metabolic syndrome

Physical activity, exercise and low-grade systemic inflammation

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