C-reactive protein for detection and follow-up of bacterial and fungal infections in severely neutropenic patients with acute leukaemia

Longitudinal trajectory patterns of plasma albumin and C-reactive protein levels around diagnosis, relapse, bacteraemia, and death of acute myeloid leukaemia patients

“…2). This is also found in studies with many non-bacteraemic infectious episodes detected from medical records [6][7][8][9][10]. Thus, other infections than bacteraemia occur close to AML-related events in our study.…”

“…Smaller studies of longitudinally measured CRP in leukaemia patients (n = 20-63) found that CRP levels > 100 mg/L correlated temporally with infectious episodes [6][7][8][9][10]. Some of these studies also assessed CRP levels in leukaemia relapse episodes, which were generally much lower than 100 mg/L [6,7,9]. To our knowledge, no study has assessed PA as a biomarker of infectious or cancer episodes in haematological cancer patients, or in any other cancer patient group.…”

“…The main strengths of this study are the populationbased design (including virtually all adult patients with AML from a geographically well-defined region), complete follow-up, and the high number of patients and specimens. Previous studies on longitudinal CRP analyses in leukaemia patients have included 20-63 patients [6][7][8][9][10] and our study is the first to assess PA. The high number of patients and specimens enabled longitudinal analyses and a two-stage approach in which we first assessed all 818 patients individually and thereafter aggregated their data.…”

Longitudinal trajectory patterns of plasma albumin and C-reactive protein levels around diagnosis, relapse, bacteraemia, and death of acute myeloid leukaemia patients

“…2). This is also found in studies with many non-bacteraemic infectious episodes detected from medical records [6][7][8][9][10]. Thus, other infections than bacteraemia occur close to AML-related events in our study.…”

“…Smaller studies of longitudinally measured CRP in leukaemia patients (n = 20-63) found that CRP levels > 100 mg/L correlated temporally with infectious episodes [6][7][8][9][10]. Some of these studies also assessed CRP levels in leukaemia relapse episodes, which were generally much lower than 100 mg/L [6,7,9]. To our knowledge, no study has assessed PA as a biomarker of infectious or cancer episodes in haematological cancer patients, or in any other cancer patient group.…”

“…The main strengths of this study are the populationbased design (including virtually all adult patients with AML from a geographically well-defined region), complete follow-up, and the high number of patients and specimens. Previous studies on longitudinal CRP analyses in leukaemia patients have included 20-63 patients [6][7][8][9][10] and our study is the first to assess PA. The high number of patients and specimens enabled longitudinal analyses and a two-stage approach in which we first assessed all 818 patients individually and thereafter aggregated their data.…”

C-reactive protein and interleukin-6 responses for differentiating fungal and bacterial aetiology in late-onset neonatal sepsis

“…[10] found that the serum CRP levels measured on the first day of infection were significantly higher in patients with fungal disease than in those with non‐fungal disease. Timonen and Koistinen [11] reported that CRP was very valuable for detecting possible invasive fungal infections, in addition to its value in the follow‐up of infections and in the detection of infectious complications. Our results concur with these findings.…”

Characteristics of Febrile Patients with Normal White Blood Cell Counts and High C‐Reactive Protein Levels in an Emergency Department

“…Many studies have focused on the use of CRP in patients with malignancy, hematologic disease or neutropenia, because these patients do not have normal WBC response to infection [3,4,12,[15][16][17][18][19][20][21][22]. Such studies have shown that CRP could help to diagnose sepsis in such patients.…”

Longitudinal trajectory patterns of plasma albumin and C-reactive protein levels around diagnosis, relapse, bacteraemia, and death of acute myeloid leukaemia patients

“…2). This is also found in studies with many non-bacteraemic infectious episodes detected from medical records [6][7][8][9][10]. Thus, other infections than bacteraemia occur close to AML-related events in our study.…”

“…Smaller studies of longitudinally measured CRP in leukaemia patients (n = 20-63) found that CRP levels > 100 mg/L correlated temporally with infectious episodes [6][7][8][9][10]. Some of these studies also assessed CRP levels in leukaemia relapse episodes, which were generally much lower than 100 mg/L [6,7,9]. To our knowledge, no study has assessed PA as a biomarker of infectious or cancer episodes in haematological cancer patients, or in any other cancer patient group.…”

“…The main strengths of this study are the populationbased design (including virtually all adult patients with AML from a geographically well-defined region), complete follow-up, and the high number of patients and specimens. Previous studies on longitudinal CRP analyses in leukaemia patients have included 20-63 patients [6][7][8][9][10] and our study is the first to assess PA. The high number of patients and specimens enabled longitudinal analyses and a two-stage approach in which we first assessed all 818 patients individually and thereafter aggregated their data.…”

C-reactive protein and interleukin-6 responses for differentiating fungal and bacterial aetiology in late-onset neonatal sepsis

“…[10] found that the serum CRP levels measured on the first day of infection were significantly higher in patients with fungal disease than in those with non‐fungal disease. Timonen and Koistinen [11] reported that CRP was very valuable for detecting possible invasive fungal infections, in addition to its value in the follow‐up of infections and in the detection of infectious complications. Our results concur with these findings.…”

Characteristics of Febrile Patients with Normal White Blood Cell Counts and High C‐Reactive Protein Levels in an Emergency Department

“…Many studies have focused on the use of CRP in patients with malignancy, hematologic disease or neutropenia, because these patients do not have normal WBC response to infection [3,4,12,[15][16][17][18][19][20][21][22]. Such studies have shown that CRP could help to diagnose sepsis in such patients.…”

Longitudinal trajectory patterns of plasma albumin and C-reactive protein levels around diagnosis, relapse, bacteraemia, and death of acute myeloid leukaemia patients

“…2). This is also found in studies with many non-bacteraemic infectious episodes detected from medical records [6][7][8][9][10]. Thus, other infections than bacteraemia occur close to AML-related events in our study.…”

“…Smaller studies of longitudinally measured CRP in leukaemia patients (n = 20-63) found that CRP levels > 100 mg/L correlated temporally with infectious episodes [6][7][8][9][10]. Some of these studies also assessed CRP levels in leukaemia relapse episodes, which were generally much lower than 100 mg/L [6,7,9]. To our knowledge, no study has assessed PA as a biomarker of infectious or cancer episodes in haematological cancer patients, or in any other cancer patient group.…”

“…The main strengths of this study are the populationbased design (including virtually all adult patients with AML from a geographically well-defined region), complete follow-up, and the high number of patients and specimens. Previous studies on longitudinal CRP analyses in leukaemia patients have included 20-63 patients [6][7][8][9][10] and our study is the first to assess PA. The high number of patients and specimens enabled longitudinal analyses and a two-stage approach in which we first assessed all 818 patients individually and thereafter aggregated their data.…”

C-reactive protein and interleukin-6 responses for differentiating fungal and bacterial aetiology in late-onset neonatal sepsis

“…[10] found that the serum CRP levels measured on the first day of infection were significantly higher in patients with fungal disease than in those with non‐fungal disease. Timonen and Koistinen [11] reported that CRP was very valuable for detecting possible invasive fungal infections, in addition to its value in the follow‐up of infections and in the detection of infectious complications. Our results concur with these findings.…”

Characteristics of Febrile Patients with Normal White Blood Cell Counts and High C‐Reactive Protein Levels in an Emergency Department

“…Many studies have focused on the use of CRP in patients with malignancy, hematologic disease or neutropenia, because these patients do not have normal WBC response to infection [3,4,12,[15][16][17][18][19][20][21][22]. Such studies have shown that CRP could help to diagnose sepsis in such patients.…”