2012
DOI: 10.1056/nejmoa1107477
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Abstract: BACKGROUND There is debate about the value of assessing levels of C-reactive protein (CRP) and other biomarkers of inflammation for the prediction of first cardiovascular events. METHODS We analyzed data from 52 prospective studies that included 246,669 participants without a history of cardiovascular disease to investigate the value of adding CRP or fibrinogen levels to conventional risk factors for the prediction of cardiovascular risk. We calculated measures of discrimination and reclassification during f… Show more

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Cited by 882 publications
(381 citation statements)
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“…These findings are in accordance with previous studies, suggesting little additional predictive benefit when traditional risk factors are taken into account 34. Notably, the only biomarker showing an opposite association with CVE risk in SMART compared with EPIC‐NL was adiponectin.…”
Section: Discussionsupporting
confidence: 92%
“…These findings are in accordance with previous studies, suggesting little additional predictive benefit when traditional risk factors are taken into account 34. Notably, the only biomarker showing an opposite association with CVE risk in SMART compared with EPIC‐NL was adiponectin.…”
Section: Discussionsupporting
confidence: 92%
“…It has been thought that serum hs‐CRP level leads to the development of atherosclerosis5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16. Although various new pharmacological approaches have been introduced to reduce hs‐CRP levels17, 18, 19, 20, 21, 22, 23, 24, 25, 26, there are still many cardiovascular diseases all over the world.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, it has been reported that hs‐CRP level is associated with carotid atherosclerosis in patients with type 2 diabetes mellitus5, 6, 7, 8, suggesting that hs‐CRP is a useful marker to predict an accelerated atherosclerotic process. It has also been shown that elevated hs‐CRP levels are associated with increased cardiovascular risk9, 10, 11, 12.…”
Section: Introductionmentioning
confidence: 99%
“…For example, higher levels of the acute‐phase reactant C‐reactive protein (CRP) are associated with an increased risk of developing CVD 16 and a variety of other disease end‐points 17. Studies have demonstrated that higher levels of interleukin (IL)‐6 are associated with an increased risk of coronary heart disease (CHD) 18, including studies examining long‐term exposure to elevated IL‐6 19 or functional genetic variants of IL‐6 signalling 20, suggesting that the association is causal.…”
Section: Introductionmentioning
confidence: 99%