C-Reactive Protein as a Prognostic Variable That Reflects Uncontrolled Up-Regulation of the IL-1-IL-6 Network System in Colorectal Carcinoma

Miki, Chikao; Konishi, Naomi; Ojima, Eiki; Hatada, Tsuyoshi; Inoue, Yasuhiro; Kusunoki, Masato

doi:10.1023/b:ddas.0000034556.48527.6e

Cited by 104 publications

(69 citation statements)

References 18 publications

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“…One of the most popular theories is that inflammatory cytokines, including interleukin (IL)‐1, IL‐6, and tumor necrosis factor (TNF), might promote tumor proliferation, survival, avoidance of apoptosis, progression of metastasis, and resistance to drug therapy. For example, Miki et al 56. have demonstrated that intense surgical stress and presence of an acute‐phase reactant were independently associated with the overexpression of IL‐6 in tumors.…”

Section: Resultsmentioning

confidence: 99%

Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature

Shimada

Fukagawa

Haga

et al. 2017

Annals of Gastroent Surgery

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PurposeThe impact of postoperative complications on survival after radical surgery for esophageal, gastric, and colorectal cancers remains controversial. We conducted a systematic review of recent publications to examine the effect of postoperative complications on oncological outcome.MethodsA literature search of PubMed/MEDLINE was performed using the keywords “esophageal cancer,” “gastric cancer,” and “colorectal cancer,” obtaining 27 reports published online up until the end of April 2016. Articles focusing on (i) postoperative morbidity and oncological outcome; and (ii) body mass index (BMI), postoperative morbidity, and oncological outcome, were selected. Univariate and multivariate analyses (Cox proportional hazards model) were performed.ResultsPatients with postoperative complications had significantly poorer long‐term survival than those without complications. Complications were associated with impaired oncological outcomes. The hazard ratios for overall survival were 1.67 (95% confidence interval [CI], 1.31‐2.12), 1.59 (95% CI, 1.13‐2.24), and 1.55 (95% CI, 1.28‐1.87) in esophageal, gastric, and colorectal cancers, respectively. High BMI was associated with postoperative morbidity rate but not with poor oncological outcome. Low BMI was significantly associated with inferior oncological outcome.ConclusionsComplications after radical surgery for esophageal, gastric, and colorectal cancers are associated with patient prognosis. Avoiding such complications might improve the outcomes.

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Section: Resultsmentioning

confidence: 99%

Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature

Shimada

Fukagawa

Haga

et al. 2017

Annals of Gastroent Surgery

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“…Angiogenesis plays an important role in tumour growth and is associated with a poor outcome in patients with GI tumours (Tanigawa et al, 1997;Fondevila et al, 2004). In addition, interleukin (IL) -1 and -6 network is upregulated (Vidal-Vanaclocha et al, 2000;Miki et al, 2004). Interleukin 1 is involved in the development of metastasis in animal studies and IL-6, apart from being a growth factor, promotes resistance to apoptosis (Vidal-Vanaclocha et al, 1994Chauhan et al, 1997;Frassanito et al, 2001;Jee et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

C-reactive protein as a predictor of prognosis following curative resection for colorectal liver metastases

et al. 2007

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There is increasing evidence that systemic inflammatory response has a positive correlation with a poorer outcome in patients undergoing resection for solid tumours. The aim of this study was to analyse the impact of an elevated C-reactive protein (CRP), an outcome following curative resection for colorectal liver metastases. One hundred and seventy patients who underwent curative resection for colorectal liver metastases were included in the study. Laboratory measurements of haemoglobin, white cell, platelets, albumin and CRP were taken on the day before surgery. Elevated CRP (410 mg l À1 ) was present in 54 (31.8%) patients. The median survival of patients with an elevated CRP was 19 months (95% CI 7.5 -31.2 months) compared to 42.8 months (95% CI 33.2 -52.5 months) for those with a normal CRP, P ¼ 0.004. Similarly, when assessing disease-free survival, patients with an elevated CRP had poorer disease-free survival (median of 11.8 months (95% CI 6.4 -17.3) compared to median of 15.1 months (95% CI 11.1 -19.1)), P ¼ 0.043. The result of the study showed that an elevated preoperative CRP is a predictor of poor outcome in patients undergoing curative resection for colorectal liver metastases.

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“…This might therefore suggest that interleukin-6 is produced by the tumour cells (Kinoshita et al, 1999;Belluco et al, 2000;Miki et al, 2004). If this were to prove to be the case, it would have important implications for the treatment of the systemic inflammatory response in patients with different tumours.…”

Section: Discussionmentioning

confidence: 99%

The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer

et al. 2005

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There is increasing evidence that both local and systemic inflammatory responses play an important role in the progression of a variety of common solid tumours. The aim of the present study was to examine the relationship between tumour T-lymphocyte subset infiltration, the systemic inflammatory response and cancer-specific survival in patients with colorectal cancer. In all, 147 patients undergoing potentially curative resection for colorectal cancer were studied. Circulating concentrations of C-reactive protein were measured prior to surgery. CD4 þ and CD8 þ T-lymphocyte infiltration of the tumour was assessed using immunohistochemistry and a point counting technique. When patients were grouped according to the percentage tumour volume of CD4 þ T-lymphocytes, there was no difference in terms of age, sex, tumour site, stage and tumour characteristics. However, there was an inverse relationship between percentage tumour CD4 þ T-lymphocytes and C-reactive protein (Po0.01). On univariate analysis, both C-reactive protein concentrations (Po0.001) and percentage tumour volume of CD4 þ (Po0.05) T-lymphocytes were associated with cancer-specific survival. The results of the present study show that low tumour CD4 þ T-lymphocyte infiltration is associated with elevated C-reactive protein concentrations and both predict poor cancer-specific survival.

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C-Reactive Protein as a Prognostic Variable That Reflects Uncontrolled Up-Regulation of the IL-1-IL-6 Network System in Colorectal Carcinoma

Cited by 104 publications

References 18 publications

Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature

Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature

C-reactive protein as a predictor of prognosis following curative resection for colorectal liver metastases

The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer

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