C-reactive Protein and Risk of Colorectal Adenomas or Serrated Polyps: A Prospective Study

Crockett, Seth D.; Mott, Leila A.; Barry, Elizabeth L.; Figueiredo, Jane C.; Burke, Carol A.; Baxter, Gwen; Sandler, Robert S.; Baron, John A.

doi:10.1158/1940-6207.capr-14-0167

Cited by 11 publications

(12 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…C‐reactive protein is an inflammatory cytokine that has been positively associated with colorectal cancer risk in prospective studies, including the CLUE II cohort . However, research on CRP serum levels and adenomas has produced conflicting results and we found no association of serum CRP and adenomas in CLUE II . We also previously reported no association between circulating CRP and the level of inflammation in normal colonic tissue measured concurrently from individuals undergoing routine screening colonoscopy .…”

Section: Discussioncontrasting

confidence: 63%

Polymorphisms in genes related to inflammation and obesity and colorectal adenoma risk

Huang

Tsilidis

Smith

et al. 2018

Molecular Carcinogenesis

View full text Add to dashboard Cite

We previously investigated the association between single nucleotide polymorphisms (SNPs) in genes related to obesity and inflammation and colorectal cancer in the CLUE II cohort. However, the relationships between these SNPs and colorectal adenomas have not been well evaluated. In a nested case-control study of 135 incident adenoma cases and 269 matched controls in the CLUE II cohort (1989-2000), we genotyped 17 candidate SNPs in 12 genes (PPARG, TCF7L2, ADIPOQ, LEP, IL10, CRP, TLR4, IL6, IL1B, IL8, TNF, RNASEL) and 19 tagSNPs in three genes (IL10, CRP, and TLR4). Conditional logistic regression was used to calculate odds ratios (OR) for adenomas (overall and by size, histology, location, number). Polymorphisms in the inflammatory-related genes CRP, ADIPOQ, IL6, and TLR4 were observed to be associated with adenoma risk. At rs1205 in CRP, T (minor allele) carriers had a higher risk (OR 1.67, 95%CI 1.07-2.60; reference: CC) of adenomas overall and adenomas with aggressive characteristics. At rs1201299 in ADIPOQ, the AC genotype had a higher risk (OR 1.58, 95%CI 1.00-2.49) of adenomas, while the minor AA genotype had a borderline inverse association (OR 0.44, 95%CI 0.18-1.08; reference: CC). At rs1800797 in IL6, the AA genotype had a borderline inverse association (OR 0.53, 95%CI 0.27-1.05; reference: GG). Three TLR4 tagSNPs (rs10116253, rs1927911, rs7873784) were associated with adenomas among obese participants. None of these SNPs were associated with colorectal cancer in our prior study in CLUE II, possibly suggesting a different genetic etiology for early colorectal neoplasia.

show abstract

Section: Discussioncontrasting

confidence: 63%

Polymorphisms in genes related to inflammation and obesity and colorectal adenoma risk

Huang

Tsilidis

Smith

et al. 2018

Molecular Carcinogenesis

View full text Add to dashboard Cite

show abstract

“…Positive associations between CRP and adenoma have not been consistently observed in previous studies. 20 21 22 23 In a small case-control study, serum CRP was not associated with increased risk of colorectal adenoma; however, that study was limited, as only 135 adenoma cases were analyzed. 23 In a case-control study from Korea, serum CRP was not significantly different between normal and adenoma groups.…”

Section: Discussionmentioning

confidence: 99%

“… 15 16 19 A recent meta-analysis found a positive association between CRP level and CRC risk. 14 Due to the inconsistencies in previous results, 17 20 21 22 26 27 28 little was conclusively known about the relationship between CRP and colorectal adenoma. In a Japanese case-control study, Otake et al 26 reported a positive association between CRP and prevalence of large adenomas.…”

Section: Discussionmentioning

confidence: 99%

“… 14 Although a positive correlation between serum CRP level and risk of colorectal neoplasia has been demonstrated, 15 16 17 18 19 several subsequent studies have shown inconsistent results. 20 21 22 23 The discrepancies between previous studies might be influenced by ethnic population and sex effects. Furthermore, little is known about the association between serum CRP level and risk of colorectal adenoma, a precursor lesion of CRC.…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

High C-reactive protein level is associated with high-risk adenoma

et al. 2017

View full text Add to dashboard Cite

Patients with IBD have an increased risk of CRC, 5 and laboratory animals with continuous inflammatory conditions are predisposed to CRC development. 6 Several studies have shown a reduced occurrence of CRC with aspirin or NSAID use. [7][8][9][10][11][12][13] CRP, a widely used maker of inflammation, could be used as a marker to identify individuals at risk for developing CRC.14 Although a positive correlation between serum CRP level and risk of colorectal neoplasia has been demonstrated, [15][16][17][18][19] several subsequent studies have shown inconsistent results. [20][21][22][23] The discrepancies between previous studies might be influenced by ethnic population and sex effects. Furthermore, little is known about the association between serum CRP level and risk of colorectal adenoma, a precursor lesion of CRC. Chiu et al. 17 showed a positive association between serum CRP level and risk of colorectal neoplasia in INTRODUCTIONColorectal cancer (CRC) is an important public health concern, and its incidence has been increasing worldwide. 1,2As most CRCs develop from colorectal adenomas through the adenoma-carcinoma sequence, CRC screening can decrease CRC-related mortality through early detection and removal of colorectal adenomas.3,4 Growing evidence supports a role of inflammation in the pathogenesis of CRC. Background/Aims: There is substantial evidence supporting a role of inflammation in the pathogenesis of colorectal cancer; however, little is known about the association between serum C-reactive protein (CRP) and the risk of colorectal adenoma. This study was conducted to investigate the association between serum CRP and colorectal adenoma risk. Methods: A retrospective cross-sectional study was performed on first-time screening colonoscopies in asymptomatic subjects who also had their serum CRP level measured during a routine health check-up between September 2006 and September 2009 in Korea. Serum CRP level was compared between high-risk and low-risk adenoma groups and independent predictors of high-risk adenoma were analyzed using multivariate regression analysis. Results: Among the 3,309 eligible patients, the high-risk adenoma group had higher serum CRP levels than the low-risk adenoma group (P=0.000). In addition, patients with a high-risk adenoma were more frequently included in the high CRP group than in the low CRP group (8.6% vs. 4.0%, P<0.001). The prevalence of high-risk adenoma was 3.5 times higher in the highest quartile of CRP level (P=0.000) compared with that in the lowest quartile. In logistic regression analysis, a higher quartile CRP level was found to be an independent risk factor for high-risk adenoma (odds ratio, 1.8; 95% confidence interval, 1.3-2.5; P=0.000). Conclusions: High CRP level is associated with high-risk adenoma in both men and women. Our data may support the association between chronic inflammation and colorectal neoplasia, which warrants further investigation. (Intest Res 2017;15:511-517)

show abstract

“…Research phase clinical studies support that Galectin-3 ligand is elevated in colorectal cancers and that its binding partner galectin-3 is also increased in cancers 14,46 hs-CRP Inflammation is an early hallmark in cancer development, and indication is that CRP measurement may be helpful in assessment for patient risk for having screening relevant findings [47][48][49][50] Ferritin Ferritin, like CRP, is considered an acute phase reactant, with levels increasing in various clinical conditions including infections and cancers 18,48 Tumor Markers and Signatures well as age and gender identifying the model with the highest likelihood score. 29 This model was then used for the secondary endpoints.…”

Section: Galectin-3mentioning

confidence: 99%

Detection of colorectal neoplasia: Combination of eight blood-based, cancer-associated protein biomarkers

et al. 2017

View full text Add to dashboard Cite

Serological biomarkers may be an option for early detection of colorectal cancer (CRC). The present study assessed eight cancer-associated protein biomarkers in plasma from subjects undergoing first time ever colonoscopy due to symptoms attributable to colorectal neoplasia. Plasma AFP, CA19-9, CEA, hs-CRP, CyFra21-1, Ferritin, Galectin-3 and TIMP-1 were determined in EDTA-plasma using the Abbott ARCHITECT® automated immunoassay platform. Primary endpoints were detection of (i) CRC and high-risk adenoma and (ii) CRC. Logistic regression was performed. Final reduced models were constructed selecting the four biomarkers with the highest likelihood scores. Subjects (N = 4,698) were consecutively included during 2010-2012. Colonoscopy detected 512 CRC patients, 319 colonic cancer and 193 rectal cancer. Extra colonic malignancies were detected in 177 patients, 689 had adenomas of which 399 were high-risk, 1,342 had nonneoplastic bowell disease and 1,978 subjects had 'clean' colorectum. Univariable analysis demonstrated that all biomarkers were statistically significant. Multivariate logistic regression demonstrated that the blood-based biomarkers in combination significantly predicted the endpoints. The reduced model resulted in the selection of CEA, hs-CRP, CyFra21-1 and Ferritin for the two endpoints; AUCs were 0.76 and 0.84, respectively. The postive predictive value at 90% sensitivity was 25% for endpoint 1 and the negative predictive value was 93%. For endpoint 2, the postive predictive value was 18% and the negative predictive value was 97%. Combinations of serological protein biomarkers provided a significant identification of subjects with high risk of the presence of colorectal neoplasia. The present set of biomarkers could become important adjunct in early detection of CRC.

show abstract

C-reactive Protein and Risk of Colorectal Adenomas or Serrated Polyps: A Prospective Study

Cited by 11 publications

References 23 publications

Polymorphisms in genes related to inflammation and obesity and colorectal adenoma risk

Polymorphisms in genes related to inflammation and obesity and colorectal adenoma risk

High C-reactive protein level is associated with high-risk adenoma

Detection of colorectal neoplasia: Combination of eight blood-based, cancer-associated protein biomarkers

Contact Info

Product

Resources

About