C - reactive protein: An inflammatory marker with specific role in physiology, pathology, and diagnosis

Chandrashekara, S

doi:10.15305/ijrci/v2is1/117

Cited by 26 publications

(15 citation statements)

References 113 publications

(58 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In case of decompensation of system controlling the inflammatory response may cause pathological course of pregnancy [3]. C-reactive protein (hs-CRP) is a blood test marker for inflammation in the body of pregnant women [4]. In most of cases inflammatory centers are located in places of damage of endo-and myometrium during trophoblast invasion [5,6], but sometimes occurs general inflammation.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum High-Sensitivity C-Reactive Protein Levels During Various Periods of Pregnancy in Woman, Infected With Parvovirus - B19 Infection

Bondarenko

2018

EUREKA: Health Sciences

View full text Add to dashboard Cite

The aim of the research was analyze of C-reactive protein levels in serum blood samples during various periods of pregnancy in women, infected with parvovirus B19 and in case of presence of clinical complications. 129 pregnant women, infected with parvovirus B19 infection and 16 women with physiological pregnancy during first, second and third trimesters of pregnancy were examined. Depending on the presence or absence of clinical complications each group of pregnant women (I, II, III) was divided into two subgroups. The concentration of C-reactive protein in blood serum was determined by the method of immunoassay analysis using diagnostic sets of reagents (ELISA kits, USA). Statistical processing of data was carried out using the package of applied programs Microsoft Office Excel 2010 and StatSoft Statistica 6.1. The mean age of pregnant woman in our study was 26±6 years. In the Iand II groups of infected B19 parvovirus pregnant women were identified a significant increasing of C-reactive protein levels compared to controls by 62.5 % and 50.0 % (p<0.05). The largest increasing of C-reactive protein level relative to control values was observed in women with clinical complications in different pregnancy periods (p<0.05). An increase levels of the marker of systemic inflammation the C-reactive protein in the blood testifies to its active participation in the launch of a complex mechanism for the development of labor activity and the occurrence of fetal disorders, which was confirmed in groups of pregnant women with clinical complications in different periods of pregnancy.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum High-Sensitivity C-Reactive Protein Levels During Various Periods of Pregnancy in Woman, Infected With Parvovirus - B19 Infection

Bondarenko

2018

EUREKA: Health Sciences

View full text Add to dashboard Cite

show abstract

“…From this entire group, we selected participants whose BMI was over 30 kg/m 2 ( n = 2,460). Next, participants with serum CRP levels higher than 10 mg/L were excluded ( n = 302), as such elevations may indicate ongoing acute inflammation (Chandrashekara, 2014). In addition, those with missing CRP values and those who had not replied to the depression screening questionnaires were further excluded ( n = 577), leading to a final analysis sample of 1,581.…”

Section: Methodsmentioning

confidence: 99%

Nonlinear Relationship Between C-Reactive Protein and Depression Among Obese Middle-Aged Adults

2023

View full text Add to dashboard Cite

Background: Despite the agreement on the significance of the relationship between the C-reactive protein (CRP) and depression, research results have been discrepant by gender.Objective: We attempted to address this uncertainty via a generalized additive model and more carefully analyzed the shape of the CRP-depression relationship in terms of sex.Methods: This is a secondary data analysis using the National Health and Nutrition Examination Survey (2017-2020) data targeting 1,581 obese middle-aged adults (40-70 years, 51.4% women) with CRP ≤ 10 mg/L. The study outcome was depression severity, assessed by the nine-item Patient Health Questionnaire. Several models were built, adjusting for relevant sociodemographic, lifestyle, and clinical covariates. The value of the effective degree of freedom (EDF) quantifies curvature of the relationship. The threshold effect was investigated using a two-piecewise linear regression model, when needed.Results: Among men, an increasing linear pattern was found (EDF ≈ 1). Contrastingly among women, the EDF value was > 2 in all unadjusted and adjusted models, indicating the smooth (curved) association. The threshold level affected the association pattern particularly for women, among whom the depression severity related to CRP significantly increased as the CRP level increased to an inflection point of 3.6 mg/L but decreased thereafter.Discussion: Assuming linearity for the CRP association with depression may not be appropriate for middle-aged obese women. Although we do not claim to provide a definite method of assessing the CRP-depression relationship, we hope to offer a different perspective when exploring this relationship. Thus, the results should be interpreted cautiously, and future studies on this topic should replicate this approach with generalized additive models.

show abstract

“…To investigate the role of IG%, procalcitonin, and other hemogram-related inflammatory parameters and indices, patients were classified into three groups according to their CRP level following the criteria described by Chandrashekara et al [9]. Group I had a CRP-value of <3 mg/L (non-inflammatory group)(n=58), Group II had a CRP level between 3 to 9 mg/L (low-grade inflammatory group) (n=59), and Group III had a CRP level of >9 mg/L (clinically significant inflammatory group) (n=44).…”

Section: Methodsmentioning

confidence: 99%

The Role of Immature Granulocytes and Inflammatory Hemogram Indices in the Inflammation

İncir¹

2020

Int J Med Biochem

View full text Add to dashboard Cite

The role of immature granulocytes and inflammatory hemogram indices in the inflammation I nflammation should be rapidly detected and differentiated to determine the underlying pathology. It is vital to distinguish any infection from other causes of inflammation because of early intervention. If a physician suspects of inflammation or infection after a physical examination, biochemical markers or blood cultures are needed for making a correct diagnosis. As these are time-consuming and not cost-effective, faster and cheaper indicators are required for early intervention [1,2]. In this regard, inflammatory markers, such as C-re-active protein (CRP) and procalcitonin, have been routinely used for the early diagnosis [3]. By the development of new hematology analyzers, the early detection of inflammation has become possible. Recent studies have pointed out that leukocyte count, absolute neutrophil count (ANC) and band count may be an early indicator of inflammation or sepsis [4]. The Sysmex XN-3100 (Sysmex Corporation, Kobe, Japan) enables to detect the percentage of immature granulocytes (IG%) using flow cytometry in the Objectives: In this retrospective study, we aimed to assess the role of immature granulocyte percentage (IG%), inflammatory complete blood count (CBC) parameters and indices in investigating the severity of inflammation, to evaluate their correlation, and to determine their predictive ability in classifying inflammation. Methods: We obtained hematological and biochemical data of the 161 outpatients for this study. Patients were assigned to three groups according to their C-reactive protein (CRP) levels. Group I had a CRp-value of <3 mg/L (non-inflammatory group) (n=58), Group II had a CRP level between 3 to 9mg/L (low-grade inflammatory group) (n=59), and Group III had a CRP level of >9mg/L (clinically significant inflammatory group)(n=44). The between-group differences were evaluated concerning sex, age, CRP, procalcitonin, IG%, CBC parameters and indices, including Platelet-to-Lymphocyte Ratio (PLR), Neutrophil-to-Lymphocyte Ratio (NLR) and Systemic Immune-Inflammatory Index (SII). Results: In Group II, the levels of CRP (p<0.0001), platelet count (p<0.05), PLR (p<0.05), NLR (p<0.05) and SII (p<0.01) were significantly higher than those in the Group I. In Group III, CRP (p<0.0001), IG% (p<0.0001), procalcitonin (p<0.01), platelet count (p<0.05), PLR (p<0.01), NLR (p<0.05) and SII (p<0.01) values showed a significant between-group difference when compared to Group I. A significant difference between Group II and Group III was detected for, CRP (p<0.0001) and IG% (p<0.05). There were significant positive correlations among IG% and CRP (p<0.001), platelet count (p<005), PLR (p<0.05) and SII (<0.05). The sensitivity and specificity values of the IG% using a cut-off value of >0.2 were 75.3% and 52.5%, respectively. Conclusion:The findings obtained in this study suggest that to detect the severity of inflammation, it would be more reliable to evaluate the combination of CBC parameters with biochemical ma...

show abstract

C - reactive protein: An inflammatory marker with specific role in physiology, pathology, and diagnosis

Cited by 26 publications

References 113 publications

Evaluation of Serum High-Sensitivity C-Reactive Protein Levels During Various Periods of Pregnancy in Woman, Infected With Parvovirus - B19 Infection

Evaluation of Serum High-Sensitivity C-Reactive Protein Levels During Various Periods of Pregnancy in Woman, Infected With Parvovirus - B19 Infection

Nonlinear Relationship Between C-Reactive Protein and Depression Among Obese Middle-Aged Adults

The Role of Immature Granulocytes and Inflammatory Hemogram Indices in the Inflammation

Contact Info

Product

Resources

About