C-Methylated Flavonoids from <i>Cleistocalyx operculatus</i> and Their Inhibitory Effects on Novel Influenza A (H1N1) Neuraminidase

Đào, Trọng Tuấn; Tung, Bui-Thanh; Nguyen, Phi‐Hung; Thuong, Phuong-Thien; Yoo, Sung-Sik; Kim, Eun‐Hee; Kim, Sang Kyum; Oh, Won Keun

doi:10.1021/np1002753

Cited by 95 publications

(48 citation statements)

References 31 publications

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“…Among them, a pronounced neuroaminidase-inhibiting effect was observed for the herb extract of Elsholtzia rugulos. Some extracts from Agrimonia pilosa, 66 Echinacea purpurea, 67 and Prunus mume 68 or the multicomponent mixtures polyphenol fractions from Punica granatum 69 and secoiridoid glucosides from Ligustrum lucidum 70 have shown a significant reduction of virus-induced cytopathic effects and in general antiviral or anti-influenza activity.…”

Section: Natural Productsmentioning

confidence: 99%

Promising approaches for the treatment and prevention of viral respiratory illnesses

Papadopoulos

Megremis

Kitsioulis

et al. 2017

Journal of Allergy and Clinical Immunology

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Viral respiratory tract infections are the most common human ailments, leading to enormous health and economic burden. Hundreds of viral species and subtypes have been associated with these conditions, with influenza viruses, respiratory syncytial virus, and rhinoviruses being the most frequent and with the highest burden. When considering prevention or treatment of viral respiratory tract infections, potential targets include the causative pathogens themselves but also the immune response, disease transmission, or even just the symptoms. Strategies targeting all these aspects are developing concurrently, and several novel and promising approaches are emerging. In this perspective we overview the entire range of options and highlight some of the most promising approaches, including new antiviral agents, symptomatic or immunomodulatory drugs, the re-emergence of natural remedies, and vaccines and public health policies toward prevention. Wide-scale prevention through immunization appears to be within reach for respiratory syncytial virus and promising for influenza virus, whereas additional effort is needed in regard to rhinovirus, as well as other respiratory tract viruses.

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Section: Natural Productsmentioning

confidence: 99%

Promising approaches for the treatment and prevention of viral respiratory illnesses

Papadopoulos

Megremis

Kitsioulis

et al. 2017

Journal of Allergy and Clinical Immunology

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“…The neuraminidase inhibition assay was performed as previously described with several modifications (Dao et al, 2010). Briefly, influenza H1N1 or H9N2 viruses were injected into MDCK cells in large-scale using DMEM containing trypsin (0.15 mg/mL) and bovine serum albumin (5 mg/mL) (BSA; Sigma-Aldrich Co., St Louis, MO, USA).…”

Section: Influenza H1n1 A/pr/8/34 and H9n2 A/chicken/korea/o1310/ 200mentioning

confidence: 99%

Chemical constituents from Melicope pteleifolia leaves

Nguyen

Choi

et al. 2016

Phytochemistry

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“…5,7-Dihydroxy-6,8-dimethylflavanone (2) has been found previously in a range of plants, including pōhutukawa (Metrosideros excelsa, Myrtaceae) (Mustafa et al 2005). It has been reported to have anti-bacterial (Massaro et al 2014), antimalarial (Boonphong et al 2007;Joseph et al 2007) and antiviral (Dao et al 2010) activities.…”

Section: Kānuka Chemistrymentioning

confidence: 95%

Mātauranga-guided screening of New Zealand native plants reveals flavonoids from kānuka (Kunzea robusta) with anti-Phytophthora activity

Lawrence

Burgess

Pairama³

et al. 2019

Journal of the Royal Society of New Zealand

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Kauri is an ecologically important and culturally treasured tree species in Aotearoa New Zealand. It is under threat from the pathogenic oomycete Phytophthora agathidicida, which causes kauri dieback disease. We hypothesised that mātauranga Māori (Māori knowledge) of kauri forest health could be used to identify native plants that produce anti-Phytophthora compounds. We tested this hypothesis by using knowledge descended from Te Whare Wananga o Ngāpuhi to select and screen four native plants for activity against P. agathidicida and also P. cinnamomi (a broad host-range pathogen). Extracts of kānuka (Kunzea robusta) were active against various life cycle stages. Bioassay-directed isolation led to three flavanones, previously unreported from New Zealand Kunzea, as the main bioactives. These compounds have not previously been reported as having anti-Phytophthora activities. They inhibited P. agathidicida zoospore germination with IC 50 values of 1.4-6.5 µg/mL, making them the most potent inhibitors reported against this stage of the life cycle. The three flavanones also inhibited zoospore motility at 2.5-5.0 µg/mL, and showed some inhibition of mycelial growth at 100 µg/mL. They were generally less active against P. cinnamomi. Overall, the results from this study emphasise the value of using mātauranga Māori in the response to kauri dieback. ARTICLE HISTORY

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C-Methylated Flavonoids from Cleistocalyx operculatus and Their Inhibitory Effects on Novel Influenza A (H1N1) Neuraminidase

Cited by 95 publications

References 31 publications

Promising approaches for the treatment and prevention of viral respiratory illnesses

Promising approaches for the treatment and prevention of viral respiratory illnesses

Chemical constituents from Melicope pteleifolia leaves

Mātauranga-guided screening of New Zealand native plants reveals flavonoids from kānuka (Kunzea robusta) with anti-Phytophthora activity

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