C-Glycosylflavones in the bulbs of squill

Fernandez, M.; Renedo, J.; Arrupe, T.; Vega, F. A.

doi:10.1016/0031-9422(75)85140-5

Cited by 11 publications

(5 citation statements)

References 3 publications

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“…It produced an ion at m/z 563, which revealed a product ion at m/z 413 (loss of a C-pentose moiety and of H 2 O) in the MS 2 experiment and a further fragmentation to yield m/z 293 in the MS 3 experiment (loss of a C-hexose moiety). Only few flavones have been described for sea squill by Fernandez and Vega [13,25,26]. However, the postulated compounds, i.e., luteolin C-glucosides, chrysoeriol C-glucosides or apigenin C-glucosides, apigenin di-C-glucoside, and apigenin C-glucoside O-xyloside, have not been detected in the present study.…”

Section: Characterization Of Individual Red Sea Squill Compoundscontrasting

confidence: 67%

Simultaneous determination of bufadienolides and phenolic compounds in sea squill (Drimia maritima (L.) Stearn) by HPLC-DAD-MSn as a means to differentiate individual plant parts and developmental stages

Knittel

Stintzing

2014

Anal Bioanal Chem

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Mediterranean sea squill (Drimia maritima (L.) Stearn) is used in the production of medicinal products. Current HPLC methods comprise tedious sample clean-up and have been merely focused on the analysis of cardiac glycosides, whereas a thorough characterization of D. maritima considering both the latter compound class and more hydrophilic secondary metabolites in one HPLC run has not been performed so far. Consequently, a novel HPLC-DAD-MS(n) method has been developed allowing the simultaneous determination of both cardiac glycosides and phenolic compounds, which is characterized by simplified sample preparation. This method was applied to characterize sea squill, revealing a complex profile of its extractive compounds derived from the two classes. Furthermore, the potential of the method reported here to quantitate the predominant compounds, i.e., dihydroquercetin derivatives and bufadienolides, was demonstrated. The occurrence of phenolic compounds, not described for sea squill so far, and of characteristic compounds specific to individual plant parts or vegetation stages was further addressed. The data revealed that classification of various vegetation phases based on quantitative evaluation of bufadienolides and dihydroquercetin derivatives applying principal component analysis (PCA) appears possible. Thus, the methodology presented here forms the basis for future routine application in quality control of raw materials and pharmaceutical preparations derived from sea squill. This will allow systematic comparison of different plant parts, vegetation stages and origins based on an extended sample set.

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Section: Characterization Of Individual Red Sea Squill Compoundscontrasting

confidence: 67%

Simultaneous determination of bufadienolides and phenolic compounds in sea squill (Drimia maritima (L.) Stearn) by HPLC-DAD-MSn as a means to differentiate individual plant parts and developmental stages

Knittel

Stintzing

2014

Anal Bioanal Chem

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“…[212][213][214][215][216] The proportion of anthocyanin was found to be higher in tetraploids than in triploids or hexaploids. 217 The [220][221][222][223] Fernandez et al identied twenty-ve avonoids in a Spanish sample of C. maritima bulbs (as Urginia maritima). They followed a parallel series: pelargonidin, kaempferol, cyaniding, quercetin and taxifolin.…”

Section: The Urgineoideaementioning

confidence: 99%

“…They have been identied as vitexin 506, isovitexin 507, orientin 508, isoorientin 509, scoparin 510 and isoscoparin 511. [220][221][222][223] Fernandez et al identied twenty-ve avonoids in a Spanish sample of C. maritima bulbs (as Urginia maritima). They followed a parallel series: pelargonidin, kaempferol, cyaniding, quercetin and taxifolin.…”

Section: The Urgineoideaementioning

confidence: 99%

“…A complex mixture of both C-and O-glycosides was obtained. 224 A fructan, sinistrin, has been isolated from C. maritima (as Urginia maritima) and found to be a mixed type b-D-fructan, with (2-1) linked and (2-6) linked unbranched b-D-fructofuranosyl and a-D-glucopyranoside residues. 225,226 C. maritima (reported as Urginia maritima) has been used as a form of rodenticide since the 13th century.…”

Section: The Urgineoideaementioning

confidence: 99%

“…Proscillaridin A 223, scillaren A 224 and scilliroside 430 were found as expected. In addition to 15 known bufadienolides found(223,224, 430, 434, 435, 436, 441-449), 10 new glucosides of known aglycones (450-459) and sixteen new compounds were isolated (460-475). An unusual 9-hydroxy bufadienolide 476 was later isolated, also from Egyptian material 208.…”

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confidence: 99%

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The chemistry and biological activity of the Hyacinthaceae

2013

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The Hyacinthaceae (sensu APGII), with approximately 900 species in about 70 genera, can be divided into three main subfamilies, the Hyacinthoideae, the Urgineoideae and the Ornithogaloideae, with a small fourth subfamily the Oziroëoideae, restricted to South America. The plants included in this family have long been used in traditional medicine for a wide range of medicinal applications. This, together with some significant toxicity to livestock has led to the chemical composition of many of the species being investigated. The compounds found are, for the most part, subfamily-restricted, with homoisoflavanones and spirocyclic nortriterpenoids characterising the Hyacinthoideae, bufadienolides characterising the Urgineoideae, and cardenolides and steroidal glycosides characterising the Ornithogaloideae. The phytochemical profiles of 38 genera of the Hyacinthaceae will be discussed as well as any biological activity associated with both crude extracts and compounds isolated. The Hyacinthaceae of southern Africa were last reviewed in 2000 (T. S. Pohl, N. R. Crouch and D. A. Mulholland, Curr. Org. Chem., 2000, 4, 1287-1324; ref. 1); the current contribution considers the family at a global level.

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