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doi:10.1001/archderm.114.9.1400

Cited by 11 publications

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“…The potential occurrence of ‘eruptive’ melanocytic naevi has also been described in other blistering disorders, such as erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrosis [17,18,19]. Although a malignant transformation has never been described so far, even after 20 years of follow-up [8, 10], it has been claimed that patients with RDEB have an increased relative risk to develop a malignant melanoma [20].…”

Section: Discussionmentioning

confidence: 99%

Acquired Melanocytic Naevus in Childhood Vulval Pemphigoid

et al. 2006

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Background: Eruptive epidermolysis bullosa (EB) naevi comprise a subset of melanocytic naevi with atypical features that characteristically occur in areas of former blistering in patients suffering from hereditary EB. Observation: The case is reported of a girl who presented with pruritus, blistering and erosions of the vulval region. Clinical and immunopathological features were consistent with the diagnosis of childhood vulval pemphigoid. In the course of the disease, she developed an atypical melanocytic naevus on the left labium at a site of former blistering. Although its clinical and dermoscopic features resembled malignant melanoma, the lesion completely regressed clinically during the 24-month follow-up. Conclusion: This is the first report describing the development of a melanocytic naevus at sites of blistering in an auto-immune subepidermal blistering disease in childhood. Our observation extends the spectrum of disorders, in addition to the group of congenital EB, in which ‘eruptive’ atypical melanocytic naevi may occur. Knowledge of this complication is important for appropriate management and follow-up and to avoid radical surgery.

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Section: Discussionmentioning

confidence: 99%

Acquired Melanocytic Naevus in Childhood Vulval Pemphigoid

et al. 2006

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Common Benign Neoplasms of Melanocytes

Schaffer¹,

Bolognia²

2006

The Pigmentary System

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Strategies for early melanoma detection: Approaches to the patient with nevi

Goodson¹,

Grossman²

2009

Journal of the American Academy of Dermatology

159

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Given its propensity to metastasize, and lack of effective therapies for most patients with advanced disease, early detection of melanoma is a clinical imperative. Although there are no non-invasive techniques for definitive diagnosis of melanoma, and the "gold standard" remains biopsy with histologic examination, a variety of modalities may facilitate early melanoma diagnosis and the detection of new and changing nevi. This article reviews general clinical principles of early melanoma detection, and various modalities that are currently available or on the horizon, providing the clinician with an up-to-date understanding of management strategies for their patients with numerous or atypical nevi.Learning objectives-At the conclusion of this learning activity, participants should: 1) understand the clinical importance of early melanoma detection; 2) appreciate the challenges of early melanoma diagnosis and which patients are at highest risk; 3) know general principles of early melanoma detection; 4) be familiar with current and emerging modalities that may facilitate early melanoma diagnosis and the detection of new and changing nevi; 5) know the advantages and limitations of each modality; and 6) be able to practice a combined approach to the patient with numerous or clinically atypical nevi.

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Untitled

Cited by 11 publications

References 0 publications

Acquired Melanocytic Naevus in Childhood Vulval Pemphigoid

Acquired Melanocytic Naevus in Childhood Vulval Pemphigoid

Common Benign Neoplasms of Melanocytes

Strategies for early melanoma detection: Approaches to the patient with nevi

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