Butyricimonas phoceensis sp. nov., a new anaerobic species isolated from the human gut microbiota of a French morbidly obese patient

Togo, Amadou Hamidou; Diop, Awa; Dubourg, Grégory; Nguyen, Thi Hong Van; Andrieu, Claudia; Caputo, Aurélia; Couderc, Carine; Fournier, Pierre‐Edouard; Maraninchi, Marie; Valéro, René; Raoult, Didier; Million, Matthieu

doi:10.1016/j.nmni.2016.07.010

Cited by 9 publications

(8 citation statements)

References 40 publications

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“…Butyricimonas bacteraemia has been described in patients with colon cancer ( 35 ) and patients with posttraumatic chronic bone and joint infections ( 36 ). It was isolated from a stool sample of a morbidly obese French patient living in Marseille, using the culturomics approach, which is critical to deciphering the links among gut microbiota and obesity ( 37 ). Recent reports link Sutterella with gastrointestinal diseases to induce substantial inflammation; rather, it can degrade IgA ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Characterization of Bacterial Microbiota Composition in Healthy and Diarrheal Early-Weaned Tibetan Piglets

Kong

Zhang

et al. 2022

Front. Vet. Sci.

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The occurrence of diarrhea in Tibetan piglets is highly notable, but the microorganisms responsible are yet unclear. Its high incidence results in serious economic losses for the Tibetan pig industry. Moreover, the dynamic balance of intestinal microflora plays a crucial role in maintaining host health, as it is a prime cause of diarrhea. Therefore, the present study was performed to analyze the characteristics of bacterial microbiota structure in healthy, diarrheal and treated weaned piglets in Tibet autonomous region for providing a theoretical basis to prevent and control diarrhea. The study was based on the V3–V4 region of the 16S rRNA gene and gut microbiota functions following the metagenome analysis of fresh fecal samples (n = 5) from different groups. The Shannon and Simpson indices differed substantially between diarrheal and treated groups (p < 0.05). According to our findings, the beta diversities, especially between healthy and diarrheal groups, were found different. Firmicutes, Bacteroidetes and Proteobacteria were the dominant phyla in three groups. Furthermore, the abundance of Fusobacteria in the diarrheal group was higher than the other groups. The dominant genera in the diarrheal group were Fusobacterium, Butyricimonas, Sutterella, Peptostreptococcus, and Pasteurella. Moreover, Lactobacillus, Megasphaera and Clavibacter were distinctly less abundant in this group. It is noteworthy that the specific decrease in the abundance of pathogenic bacteria after antibiotic treatment in piglets was noticed, while the level of Lactobacillus was evidently increased. In conclusion, fecal microbial composition and structure variations were discovered across the three groups. Also, the ecological balance of the intestinal microflora was disrupted in diarrheal piglets. It might be caused by a reduction in the relative number of beneficial bacteria and an increase in the abundance of pathogenic bacteria. In the context of advocating for non-resistant feeding, we suspect that the addition of probiotics to feed may prevent early-weaning diarrhea in piglets. Moreover, our findings might help for preventing diarrhea in weaned Tibetan piglets with a better understanding of microbial population dynamics.

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Section: Discussionmentioning

confidence: 99%

Characterization of Bacterial Microbiota Composition in Healthy and Diarrheal Early-Weaned Tibetan Piglets

Kong

Zhang

et al. 2022

Front. Vet. Sci.

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“…The Butyricimonas genus was first described by Sakamoto et al in 2009 and to date six different species are discovered [1][2][3][4]. Butyricimonas virosa, being the only known pathogenic species, has previously caused six infections reported in literature, making this the seventh [5][6][7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%

“…The novel genus is a member of the Porphyromonadaceae family. Currently there are six different species part of the Butyricimonas genus: B. virosa, B. synergistica, B. paravirosa, B. faecihominis, B. phoceensis and B. faecalis [1][2][3][4]. B. virosa is the only species within the genus known to cause infection.…”

Section: Introductionmentioning

confidence: 99%

A subcutaneous infection mimicking necrotizing fasciitis due to Butyricimonas virosa

Donder

Uyttebroek

Cleven

et al. 2019

Acta Chirurgica Belgica

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Introduction: B. virosa is a gram-negative rod who was first identified in rat faeces in 2009. Since then only six human infections have been described in literature. We report a clinical case of a subcutaneous infection mimicking necrotizing fasciitis due to B. virosa. Patient and methods: A 78-year-old man was referred to our hospital because of a wound infection with suspicion of necrotizing fasciitis. Treatment consisted of immediate surgical exploration with obtainment of intra-operative specimens for microbiologic examination, 15 days of negative pressure wound therapy (NPWT) and antibiotic treatment with piperacillin-tazobactam (12 days) plus vancomycin (9 days). Results: Surgical exploration did not show necrotising fasciitis but a subcutaneous infection mimicking necrotising fasciitis. The intra-operative specimens revealed the presence of Butyricimonas virosa and Finegoldia magna. Cultures taken during the NPWT replacements became negative and the patient was able to leave the hospital after 18 days. Conclusions: Considering there was no necrotizing infection present it may have been possible to safely close the wound sooner. However it is difficult to differentiate between an actual necrotizing fasciitis and a subcutaneous infection mimicking necrotizing fasciitis. Therefore further studies on effective assessment tools to diagnose necrotizing fasciitis could be helpful.

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“…Colony morphology and pigmentation were observed after cultivation of the strain on Columbia agar (bioMérieux, Marcy l'Etoile, France) at 37°C for 48 hours. Phenotypic characteristics of the strain was determined as previously described (Togo et al 2016a(Togo et al , 2017. API strips: (API ® 20A, API ® Rapid ID 32A, API ® ZYM, API ® and API ® 50 CH) were used according to the manufacturer's instruction (bioMérieux).…”

Section: Phenotypic and Chemical Characteristic Analysismentioning

confidence: 99%

Draft genome and description of Negativicoccus massiliensis strain Marseille-P2082, a new species isolated from the gut microbiota of an obese patient

Togo

Diop

Tall

et al. 2020

Antonie van Leeuwenhoek

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Butyricimonas phoceensis sp. nov., a new anaerobic species isolated from the human gut microbiota of a French morbidly obese patient

Cited by 9 publications

References 40 publications

Characterization of Bacterial Microbiota Composition in Healthy and Diarrheal Early-Weaned Tibetan Piglets

Characterization of Bacterial Microbiota Composition in Healthy and Diarrheal Early-Weaned Tibetan Piglets

A subcutaneous infection mimicking necrotizing fasciitis due to Butyricimonas virosa

Draft genome and description of Negativicoccus massiliensis strain Marseille-P2082, a new species isolated from the gut microbiota of an obese patient

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