2016
DOI: 10.18632/oncotarget.11267
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Abstract: Dietary supplementation of butyrate can prevent diet-induced obesity through increasing mitochondrial function in mice, yet the up-stream signaling pathway remains elusive. In this study, weaned mice were divided into two groups, fed control (CON) and high-fat diet (HF, 45% energy from fat), respectively, for 8 weeks. HFinduced obese mice, maintained on HF diet, were then divided into two groups; HFB group was gavaged with 80 mg sodium butyrate (SB) per mice every other day for 10 days, while the HF group rece… Show more

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Cited by 134 publications
(120 citation statements)
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“…However, we observed no significant difference in plasma NEFA concentration between control and butyrate-treated groups. Given that the energy expenditure, fatty acid β-oxidation and mitochondrial function in skeletal muscle were all significantly increased after a short-term oral SB treatment in a HF diet-induced mouse model (Hong et al 2016), we speculate that most of the released fatty acids from adipose tissue may be transported to muscle for β-oxidation in skeletal muscle. Therefore, a cross-talk between adipose tissue and skeletal muscle plays an important role in the regulation of plasma NEFA homeostasis.…”
Section: Discussionmentioning
confidence: 93%
“…However, we observed no significant difference in plasma NEFA concentration between control and butyrate-treated groups. Given that the energy expenditure, fatty acid β-oxidation and mitochondrial function in skeletal muscle were all significantly increased after a short-term oral SB treatment in a HF diet-induced mouse model (Hong et al 2016), we speculate that most of the released fatty acids from adipose tissue may be transported to muscle for β-oxidation in skeletal muscle. Therefore, a cross-talk between adipose tissue and skeletal muscle plays an important role in the regulation of plasma NEFA homeostasis.…”
Section: Discussionmentioning
confidence: 93%
“…An elevation of caecal Prevotella content has been reported in the high‐fat diet‐induced obese mice after supplement of arabinoxylans, which is the most abundant non‐digestible carbohydrates in wheat, and can decrease caecal inflammatory markers and improve gut barrier function . Plus, Prevotella produces butyrate that alleviates high‐fat diet‐induced obesity by improving insulin resistance via activating adiponectin signalling pathway in mice models . Therefore, the decrease in Prevotella in psoriasis patients is potentially associated with insulin resistance.…”
Section: Discussionmentioning
confidence: 99%
“…Studies in knockout mice have shown that class I HDACs play a key role in regulating metabolism. Chronic treatment with butyrate, a broad HDAC inhibitor that is expected to phenocopy HDAC3 loss-of-function, prevents metabolic alterations in dietinduced obese as well as in aged mice, mainly by enhancing oxidative phosphorylation and beta-oxidation in mitochondria (181,182). Butyrate treatment also improves mitochondrial biogenesis via epigenetic modulation of PGC-1α as well as induction of several microRNAs such as miR-133a-3p, miR-208b, and miR-499-5p, implicated in the regulation of mitochondrial potential and integrity (183).…”
Section: Epigenetic Therapiesmentioning
confidence: 99%