Butyl Nitrite–Induced Acrocyanosis in an HIV-Infected Patient

Dermatologic care for lesbian, gay, bisexual, and transgender persons

“…53,54 Chemical leukoderma in the perinasal region, acrocyanosis, and methemoglobinemia have been reported with chronic use. [55][56][57] Life-threatening hypotension can occur if "poppers" are used concurrently with phosphodiesterase-5 inhibitors, such as sildenafil. 58…”

Acrocyanosis: The Flying Dutchman

“…3,51 Butyl nitriteinduced acrocyanosis has been reported. 56 Secondary acrocyanosis is also associated 101 with many malignant and benign 28 neoplasms with or without Pulmonary hypertension 15 Pulmonary embolism 16 Pulmonary alveolar proteinosis 17 Pulmonary arteriovenous malformations 18 Acrocyanosis of infancy 19 Atheromatous embolism 20,21 Connective tissue / rheumatologic diseases:…”

The Purple Digit

“…[66] These patients may also present with acute purple digits secondary to vaso-occlusive events. Type I cryoglobulinemia [29] cold agglutinins [30] antiphospholipid antibodies [31] Medications imipramine [32] butylnitrate [33] interferon-a [34] amphotericin B deoxycholate [35] pressors a Malignancy [36] Metabolic diseases ethyl-malonic aciduria [37] fucosidosis [38] Neurologic brachial plexus neuropathy [39] spinal cord injury [40] Arsenic poisoning [41] Psychiatric Asperger disease [42] mental retardation and schizophrenia [39] 'Puffy hand syndrome' [43] Eating disorders [44,45] a Observational data. Type I cryoglobulinemia [29] cold agglutinins [30] antiphospholipid antibodies [31] Medications imipramine [32] butylnitrate [33] interferon-a [34] amphotericin B deoxycholate [35] pressors a Malignancy [36] Metabolic diseases ethyl-malonic aciduria [37] fucosidosis [38] Neurologic brachial plexus neuropathy [39] spinal cord injury [40] Arsenic poisoning [41] Psychiatric Asperger disease [42] mental retardation and schizophrenia [39] 'Puffy hand syndrome' [43] Eating disorders [44,45] a Observational data.…”