Butanol extract of 1:1 mixture ofPhellodendron cortex andAralia cortex stimulates PI3-kinase and ERK2 with increase of glycogen levels in HepG2 cells

Effects of water extract of 1:1 mixture of Phellodendron cortex and Aralia cortex on polyol pathway and oxidative damage in lenses of diabetic rats

“…Non-fasting blood glucose levels were shown to decrease a little by the treatment of P55A extract (data not shown). Recently, we presented evidence that P55A extract treatment increases hepatic glycogen content, possibly by stimulating PI 3 -kinase and ERK2 activities in HepG2 cells (Kim et al, 1998). Taken together, these results suggest that P55A extract could be used as an adjuvant to other oral hypoglycaemic agents to regulate high blood glucose levels in diabetes.…”

“…have long been used as folk medicines in Korea for the treatment of various diseases including diabetes mellitus. Recently our laboratory has provided evidence that P55A (aralia elata 1:1 mixture of and Phellodendron amurense) extract has the ability to increase the glycogen content in hepatocytes, possibly by stimulating PI 3kinase and ERK2 (Kim et al, 1998). This suggests that the P55A extract could be used to decrease high blood glucose levels in diabetic patients.…”

Water extract of Aralia elata prevents cataractogenesis in vitro and in vivo

“…These included the up-regulation of the phosphorylation of extracellular signal-regulated kinase (ERK), and of the common stress-associated mitogen-activated protein kinases p38 and SAPK/JNK (Zatechka et al, 2003). It was also reported that a 1:1 mixture of Phellodendron amurense and Aralia elata has the ability to increase glycogen contents in hepatocytes, possibly by stimulating PI3-kinase and ERK2 (Kim et al, 1998). Thus, since Aralia extract is considered to have a marked anticataract effect, it may normalize ERK-mediated signal transduction.…”

Evaluation of the key ingredient from the main production areas of Phellodendri Amurensis Cortex using ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight tandem mass spectrometry and ultra‐high‐performance liquid chromatography coupled to triple‐quadrupole mass spectrometry

“…Up to now, phytochemical research has shown that PAC contains several kinds of chemical constituents, including alkaloids, flavonoids, phenolic acids, limonoids, etc [2,3]. PAC exhibits diverse biological activities, such as anti-inflammatory [4], antipyretic [2], antibacterial [5], antivirus [6], hypoglycemic [7], antioxidant [8], and anticancer actions [9]. Nowadays, it is widely used in clinical practice with other Chinese medicine compatibility [10,11].…”