Buspirone before prenatal stress protects against adverse effects of stress on emotional and inflammatory pain-related behaviors in infant rats: Age and sex differences

Manipulation of Neurotransmitter Levels Has Differential Effects on Formalin-Evoked Nociceptive Behavior in Male and Female Mice

“…A study of prenatal stress and pain in male and female infant rats has shown that the 5-HT 1A-mediated functional maturity of the descending serotonergic inhibitory system appears earlier in male than in female rats. 10 This observation may explain why gonadectomies did not have an effect on N 2 -AcPLZmediated antinociception in the present study. Furthermore, a study of sex differences in 5-HT 1A binding affinity in a healthy human population showed a small mean reduction of binding potential in women relative to men in the prefrontal and occipital cortex, suggesting possible innate receptor expression differences between the sexes.…”

Effect of Yi-nao-jie-yu decoction on γ-aminobutyric acid type A receptor in the hippocampus and serum inflammatory factors in a rat model of poststroke anxiety

“…Although there was no statistical difference between these two treatment strategies, YNJYD exhibited multitarget characteristics with none of the adverse side effects of BuSpar, such as dizziness, nausea, headache, and nervousness (Figure 7). 38…”

Inflammatory Pain and Corticosterone Response in Infant Rats: Effect of 5-HT1A Agonist Buspirone Prior to Gestational Stress

“…A half of the treated rats from each group were randomly exposed to restraint stress for 60 min (in 5 min after buspirone injection) from GD15 to GD21. All influences on gestational females were identical to those used in our previous study [21]. The dose of buspirone was sufficient for inducing an anxiolytic effect in adult rats [40] and did not exceed the dose used for pregnant rat dams to protect the fetal serotonergic system against damaging effects of in utero ethanol exposure [41].…”

“…Investigations of formalin-induced pain effects on the HPA axis in infant rats could elucidate unexplored previously interrelations between the tonic nociceptive and stress systems during the period of hyporesponsiveness of the latter. We revealed for the first time that prenatal stress induces strengthening inflammatory pain-related response in the formalin test and decrease of adaptive capacities in infant rats; chronic injections of an agonist of serotonin (5-HT) receptors 1A (5-HT1A) buspirone to dams prior to stress during gestation cancel the adverse consequences of the stress in the offspring [21]. In prenatally stressed individuals, abnormalities in the HPA axis function [22] and neurotransmitter systems including the serotonergic one [23] were shown.…”