Burden of chronic hepatitis B and C infections in 2015 and future trends in Japan: A simulation study

Tanaka, Junko; Kurisu, Akemi; Ohara, Masatsugu; Ouoba, Serge; Ohisa, Masayuki; Sugiyama, Aya; Wang, Michelle L.; Hiebert, Lindsey; Kanto, Tatsuya; Akita, Tomoyuki

doi:10.1016/j.lanwpc.2022.100428

Cited by 27 publications

(31 citation statements)

References 30 publications

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“…Besides the global survey, the trend of decreases in hepatitis‐related services during COVID‐19 was similar to other studies conducted in the Netherlands for diagnosis 20 and Ontario (Canada) for HBV and HCV testing 21 . However, the decline of any types of service related to HBV and HCV might hamper the ability to meet the set elimination goal 2,9,18,19,22 . From the impressions of participating hepatologists, screening and confirmatory testing were observed as more greatly affected than other services during the COVID‐19 pandemic; our results recommend further study to evaluate the impact of COVID‐19 on HBV and HCV health screening facilities.…”

Section: Discussionsupporting

confidence: 83%

“…21 However, the decline of any types of service related to HBV and HCV might hamper the ability to meet the set elimination goal. 2,9,18,19,22 From the impressions of participating hepatologists, screening and confirmatory testing were observed as more greatly affected than other services during the COVID-19 pandemic; our results recommend further study to evaluate the impact of COVID-19 on HBV and HCV health screening facilities.…”

Section: Hepatology Researchmentioning

confidence: 73%

“…In addition, the National Campaign Project for Hepatitis Measures (2013) for awareness and a routine three doses of hepatitis vaccine to all infants (2017) contributed to gradual decreases in the incidence and prevalence of HBV and HCV infections 7,8 . Indeed, until 2020, Japan was moving in the right direction to achieve HBV and HCV elimination by 2030 9–11 …”

Section: Introductionmentioning

confidence: 99%

“…7,8 Indeed, until 2020, Japan was moving in the right direction to achieve HBV and HCV elimination by 2030. [9][10][11] Unfortunately, on December 31, 2019, China reported 27 cases of a new viral infection with an unknown etiology in Wuhan City of Hubei Province. 12 On February 11, 2020, this disease was officially named coronavirus disease 2019 (COVID- 19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).…”

Section: Introductionmentioning

confidence: 99%

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Effect of COVID‐19 on hepatitis B and C virus countermeasures: Hepatologist responses from nationwide survey in Japan

Hussain

Hiebert

Sugiyama

et al. 2022

Hepatology Research

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Aim Achieving hepatitis B virus (HBV) and hepatitis C virus (HCV) elimination requires continuous and sustained high volumes of diagnosis and treatment which have been affected by the ongoing COVID‐19 pandemic. This study assessed COVID‐19 effect on hepatitis‐related services in Japan and compare Japan’s situation with global survey. Methods We conducted an online cross‐sectional questionnaire survey of hepatologist of the Japan Society of Hepatology from August to October 2021 by using the same questionnaire from which a survey was conducted globally to address the COVID‐19 effect on hepatitis‐related services. Hepatologists responded based on own impression of their affiliated institutions. Results A total of 196 hepatologists participated from 35 prefectures including 49.5% were in managerial positions. Around 40% survey participants reported a 1‐25% decline in HBV and HCV screening and confirmatory testing. In addition, 53.6% and 45.4% reported no decline in HBV and HCV treatment initiation, respectively. Comparing any level of decrease, less decline was observed in Japan for screening (HBV: 51% vs 56.3%, HCV: 51% vs 70.9%) and treatment initiation (HBV: 32.7% vs 52.4%, HCV: 41.8% vs 66%) from global survey. However, Patient anxiety/fear (67.4%), and loss of staff due to COVID‐19 response (49.0%) were reported as challenges to resume services to pre‐COVID‐19 levels. Conclusion Although in Japan all‐inclusive decline in HBV and HCV related services were lower than in other countries, a greater decline was observed in HBV and HCV screening and diagnosis than in treatment initiation. Prolonged anxiety/fear among patients, loss of staffs and facilities on COVID‐19 responses must be addressed to achieve the hepatitis elimination by 2030. This article is protected by copyright. All rights reserved.

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Section: Discussionsupporting

confidence: 83%

Section: Hepatology Researchmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of COVID‐19 on hepatitis B and C virus countermeasures: Hepatologist responses from nationwide survey in Japan

Hussain

Hiebert

Sugiyama

et al. 2022

Hepatology Research

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“…Most deaths from viral hepatitis are due to HBV and HCV infections. According to the statistics, it was estimated that 296 million people were infected with hepatitis B, 58 million people were infected with hepatitis C and 1.1 million people died as a consequence of viral hepatitis infections in 2019 (Tanaka et al, 2022). In 2015, the United Nations adopted a resolution to combat viral hepatitis as part of the agenda to achieve the 2030 sustainable development goals.…”

Section: Introductionmentioning

confidence: 99%

Advances in multi-omics research on viral hepatitis

Xiang

et al. 2022

Front. Microbiol.

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Viral hepatitis is a major global public health problem that affects hundreds of millions of people and is associated with significant morbidity and mortality. Five biologically unrelated hepatotropic viruses account for the majority of the global burden of viral hepatitis, including hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and hepatitis E virus (HEV). Omics is defined as the comprehensive study of the functions, relationships and roles of various types of molecules in biological cells. The multi-omics analysis has been proposed and considered key to advancing clinical precision medicine, mainly including genomics, transcriptomics and proteomics, metabolomics. Overall, the applications of multi-omics can show the origin of hepatitis viruses, explore the diagnostic and prognostics biomarkers and screen out the therapeutic targets for viral hepatitis and related diseases. To better understand the pathogenesis of viral hepatitis and related diseases, comprehensive multi-omics analysis has been widely carried out. This review mainly summarizes the applications of multi-omics in different types of viral hepatitis and related diseases, aiming to provide new insight into these diseases.

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Hepatitis B and C infections among Japanese dental health workers: Insights from vaccination rates and screening results in the Oita prefecture

Nagao,

Kimura,

Tomooka

et al. 2024

Clinical & Exp Dental Res

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ObjectiveThis study examined the hepatitis B virus (HBV) and hepatitis C virus (HCV) infection rates and vaccination rates for hepatitis B (HB) among dental healthcare workers (DHCWs) in the Oita prefecture, Japan.MethodsHepatitis virus testing was conducted on 1920 participants (486 dentists and 1434 dental staff). Anonymous data on age, gender, occupation, hepatitis B surface antigen (HBsAg), antibodies to hepatitis B surface antigen (anti‐HBs), antibodies to HCV (anti‐HCV), history of HB vaccination, and antiviral treatment for individuals with positive anti‐HCV were collected.ResultsThe positivity rates for HBsAg, anti‐HBs, and anti‐HCV were 0.5%, 39.7%, and 0.6%, respectively. Dentists had significantly higher rates of anti‐HBs positivity (53.9% vs. 34.9%; p < .0001) and anti‐HCV positivity (1.4% vs. 0.3%; p = .0080) compared to dental staff. The vaccination and non‐vaccination rates among 1395 with a known HB vaccination history were 59.1% and 40.9%, respectively. Dentists had a significantly higher HB vaccine vaccination rate than the dental staff (73.6% vs. 54.0%; p < .0001). Those in the vaccination group were younger (p < .0001), had a higher proportion of males (p = .0022) and dentists (p < .0001), a lower HBsAg positivity rate (p < .0097), and a higher anti‐HBs positivity rate (p < .0001) compared to those in the non‐vaccination group. The positivity rate of HBsAg and anti‐HBs in the unvaccinated group increased with age, with HBsAg positivity reaching 3.8% in the 70s and anti‐HBs positivity reaching 40.4% in the 70s and 66.7% in the 80s.ConclusionsThis study highlights the need to raise awareness about hepatitis prevention vaccination, particularly among dental staff, due to differences in HB vaccination rates across occupations. In particular, they indicated that elderly DHCWs may be more vulnerable to HBV infection. Regular monitoring of the vaccination rate and infection risk is crucial.

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Burden of chronic hepatitis B and C infections in 2015 and future trends in Japan: A simulation study

Cited by 27 publications

References 30 publications

Effect of COVID‐19 on hepatitis B and C virus countermeasures: Hepatologist responses from nationwide survey in Japan

Effect of COVID‐19 on hepatitis B and C virus countermeasures: Hepatologist responses from nationwide survey in Japan

Advances in multi-omics research on viral hepatitis

Hepatitis B and C infections among Japanese dental health workers: Insights from vaccination rates and screening results in the Oita prefecture

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