Bullous Urticaria Pigmentosa

Robinson, Harry M.

doi:10.1001/archderm.1962.01590030044006

Cited by 31 publications

(13 citation statements)

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“…These two patients seem similar to four previously reported cases of "diffuse mastocytosis without visible cutaneous lesions" (12)(13)(14)(15). Other differential diagnoses are annular erythema of infancy (16), Kawasaki syndrome (17), papular urticaria (18), and infantile acute hemorrhagic edema (19).…”

Section: Discussionsupporting

confidence: 86%

Urticaria in Infants: A Study of Forty Patients

Legrain

Taı̈eb

Sage

et al. 1990

Pediatric Dermatology

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A retrospective study was carried out in 40 infants, age 1 to 24 months, with urticaria. Acute urticaria was seen most frequently (85%), followed by recurrent (10%) and chronic disease (5%). Several clinical features such as frequency of angioedema and hemorrhagic lesions appeared to be specific to urticaria in infants. An underlying cause was identified or suspected in 65% of cases: foods in 25%, and drugs and infections in 37.5%. Under 6 months of age, all infants had acute urticaria and 75% had cow's milk allergy. After 6 months of age, the main causes were drug intake (mostly aspirin and amoxicillin) and/or infections (mainly viral) (50%). Atopy was not overrepresented (20%), although a possible link between atopy and recurrent urticaria was noted. After a follow-up of 2 to 7.5 years, 96% of patients were symptom free. Thus, our results indicate that clinical and etiologic features of urticaria in infants are somewhat different from those of adults and children.

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Section: Discussionsupporting

confidence: 86%

Urticaria in Infants: A Study of Forty Patients

Legrain

Taı̈eb

Sage

et al. 1990

Pediatric Dermatology

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“…a. Selye, 1965], und bis auf Robinson et al [1962], die nur eine tem poräre Besserung sahen, wurde von den anderen Autoren die Cyproheptadinbehandlung als sehr wirksam hervorge hoben. Dass es sich dabei nicht um einen Effekt auf der Basis der Antihistaminwirkung des Cyproheptadins handelt, zeigen die ver gleichbar guten Ergebnisse von McKee et al [1966] bei UP m it Antihistaminica und Methysergid, dem bisher stärksten 5-HT-Antagonisten.…”

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“…bei Rothschild, 1966], aber kein 5-HT aus Mastzellen freisetzt [Gyermek, 1965], bei einem U P-Patienten einen Flush sahen. Die Erfolge einer Reserpinbehandlung [Robinson et al, 1962;Zabel, 1966] weisen jedoch trotz aller negativen 5-HT-Befunde bei Mastozytosen auf eine gewisse Bedeutung des Serotonins hin, da Reserpin keine direkte Wirkung auf Mastzellen besitzt [Padawer, 1966], Serotonin kann aber Histamin aus Geweben freisetzen [Feldberg und Smith, zit. bei Rothschild, 1966].…”

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Kasuistischer Beitrag zur Behandlung der Urticaria pigmentosa xanthelasmoidea bullosa mit Cyproheptadin

Haneke¹

1970

Dermatology

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A case of Urticaria pigmentosa xanthelasmoidea bullosa with generalized vascular symptoms (flushes) is reported. Blisters already appeared at the second day of life. The daily medication of 2 times 2 mg cyproheptadine soon stopped the formation of bullae, calmed the pruritus, and the flushes disappeared. Possible interrelationships between histamine and 5-hydroxytryptamine in the symptomatology of bullous urticaria pigmentosa are pointed out in the light of the action of cyproheptadine as a combined serotonin-histamine antagonist and of methysergide as a selective antiserotonin agent, respectively.

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“…Differentialdiagnostisch muß an Dermatitis herpetiformis, bullöse Impetigo, chronisch bullöse Erkrankung miliäres Vorkommen (autosomal-dominant) [14], solitär noduläre und multiple makulopapulöse sowie diffuse bullöse Formen wurden beobachtet [2,4,17]. Die Blasen entstehen offensichtlich durch Freisetzung biologisch aktiver Substanzen [1, 3] aus Granula der Mastzellen, die mittels Giemsa-und Toluidinblaufärbung histologisch nachgewiesen wurden.…”

Section: Introductionunclassified

Bull�se Mastozytose bei einem Kind

Haustein

Bedri

1997

Der Hautarzt

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We report a case of bullous mastocytosis in a 30-month-old girl, who developed disseminated pruritic urticarial and bullous lesions on the trunk accompanied by episodes of vomiting and generalized flushing. Her problems began at the age of 6 months. Her stool was repeatedly positive for occult blood. Histamine and 5-hydroxytryptamine were measured in the urine and serum; urine 5-hydroxytryptamine levels were elevated. In addition, trypsin and chymotrypsin levels were raised in the blister fluid. Metachromatic staining of the mast cells in a skin biopsy specimen confirmed the diagnosis. A combination of oral disodium cromoglycate and ketotifen produced a dramatic improvement of the cutaneous and gastrointestinal features.

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Bullous Urticaria Pigmentosa

Cited by 31 publications

References 0 publications

Urticaria in Infants: A Study of Forty Patients

Urticaria in Infants: A Study of Forty Patients

Kasuistischer Beitrag zur Behandlung der Urticaria pigmentosa xanthelasmoidea bullosa mit Cyproheptadin

Bull�se Mastozytose bei einem Kind

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