Bullous pyoderma gangrenosum and acute leukemia

Neutrophilic dermatosis of the hands: four new cases and review of the literature

“…Subsequently, other reports have confirmed the frequent association of leukemia and preleukemia with bullous pyoderma gangrenosum and atypical variants of Sweet's syndrome. 6,[21][22][23][24][25] Solid tumors have been reported rarely. 26 -29 Many cases of neutrophilic dermatosis of the hands bear clinical resemblance to bullous pyoderma gangrenosum.…”

Pyoderma gangrenosum as an Early Revelator of Acute Leukemia

“…The inflammatory infiltrate consisted of lymphocytes and numerous neutrophils. In 1978, Sheps et al [8] described a patient with tender nodules that ulcerated to form the typical lesions of bullous pyoderma gangrenosum. A skin biopsy specimen of such an early nodule showed a panniculitis with a predominance of polymorphonuclear leukocytes invading the fat septa [8].…”

“…In 1978, Sheps et al [8] described a patient with tender nodules that ulcerated to form the typical lesions of bullous pyoderma gangrenosum. A skin biopsy specimen of such an early nodule showed a panniculitis with a predominance of polymorphonuclear leukocytes invading the fat septa [8]. Suzuki et al [9] have recently reported a patient with acute myeloid leukemia, who developed an edematous erythema diagnosed as Sweet's syndrome, accompanied by painful erythematous nodules, diagnosed as atypical erythema nodosum, and bullous pyoderma gangrenosum.…”

Bullous pyoderma gangrenosum as the presenting sign of fatal acute myelogenous leukemia

“…The histologic finding of a panniculitis in early tender nodules preceding the typical lesions of bullous pyoderma gangrenosum suggested to Sheps et al [19] that bullous pyoderma gangrenosum may be the result of a primary panniculitis with subsequent migration of neutrophils in the extravascular subcutaneous tissue and dermis, with the superficial changes occurring subsequent to the panniculitis. Indeed, another report describes a patient with bullous pyoderma gangrenosum who initially presented with subcutaneous nodules with histology consistent with a panniculitis [20].…”