Bullous photodermatosis after lomefloxacin

Correia, O.

doi:10.1001/archderm.130.6.808

Cited by 31 publications

(10 citation statements)

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“…Indeed, various authors have claimed cross-reactivity between quinolones on the basis of clinical data. 6,9,[33][34][35][36][37][38] Our data support this notion because several patients reported a reaction with more than one quinolone (9/55 [16%]). Moreover, the majority of our patients revealed IgE toward more than one quinolone (24/30 [80%]).…”

Section: Discussionsupporting

confidence: 65%

Detection of specific IgE to quinolones

Manfredi

Severino

Testi

et al. 2004

Journal of Allergy and Clinical Immunology

129

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Section: Discussionsupporting

confidence: 65%

Detection of specific IgE to quinolones

Manfredi

Severino

Testi

et al. 2004

Journal of Allergy and Clinical Immunology

129

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“…Exposure to sunlight, particularly UV-A, along with the use of certain photoactive pharmaceuticals, has been associated with phototoxicity in humans (Correia et al 1994). Phototoxicity involves generation of reactive oxygen species such as H 2 O 2 , singlet oxygen, and hydroxyl radicals after interaction of light, especially UV-A, with photosensitive pharmaceuticals (Rosen et al 1997;Verna et al 1998).…”

Section: Introductionmentioning

confidence: 99%

Effects of PACAP in UV-A Radiation-Induced Retinal Degeneration Models in Rats

et al. 2010

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The retina is constantly exposed to ultraviolet (UV) light with different wavelengths, which may lead to chronic UV-induced retinal injury. In our previous studies, we have shown the protective effects of pituitary adenylate cyclase activating polypeptide (PACAP) in toxic and ischemic retinal injuries. The aim of the present study was to investigate the effects of PACAP in UV-A-induced retinal lesion. We used diffuse UV-A radiation (315-400 nm) to induce acute retinal damage over a short period of exposure. Using standard histological (morphological and morphometrical) analysis, we assessed the actions of intravitreal PACAP (100 pmol/5 µl) treatment on acute UV-A-induced retinal damage. We measured the thickness of nuclear and plexiform layers as well as the number of cells in the outer nuclear and inner nuclear layers and in the ganglion cell layer. Outer limiting membrane-inner limiting membrane distances in the cross-section of the retina were also examined. Our results show that UV-A light-induced retinal damage led to severe degeneration in the photoreceptor layer, and in the outer and inner nuclear layers. Alteration in the plexiform layers was also observed. We found that post-irradiation PACAP treatment significantly attenuated the UV-A-induced retinal damage. Our results provide the basis for future clinical application of PACAP treatment in retinal degeneration and may have clinical implications in several ophthalmic diseases.

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“…This can be reduced with drug intake by the end of the day, to reduce drug concentrations in the circulation and in the skin during the midday. Photoallergy has also been reported with lome floxacin [20,21] and enoxacin [51], sometimes with cross-reaction to other fluorquinolones (ciprofloxacin and flerofloxacin) [84,85]. Experimental …”

Section: Antimicrobialsmentioning

confidence: 99%

Phototoxic and Photoallergic Reactions

Gonçalo

2010

Contact Dermatitis

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Bullous photodermatosis after lomefloxacin

Cited by 31 publications

References 0 publications

Detection of specific IgE to quinolones

Detection of specific IgE to quinolones

Effects of PACAP in UV-A Radiation-Induced Retinal Degeneration Models in Rats

Phototoxic and Photoallergic Reactions

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