Bullous pemphigoid in childhood. Immunofluorescent studies

Fincher, D. F.

doi:10.1001/archderm.103.1.88

Cited by 26 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of IgG and complement in the upper layers of the dermis has been described by Fincher, Dupree & Bean (1971) in a case which they classified as bullous pemphigoid in childhood since circulating antibodies against basement membrane were present.…”

Section: Discussionmentioning

confidence: 95%

Juvenile pemphigoid

Faber

Joost

1973

Br J Dermatol

View full text Add to dashboard Cite

The aim of this communication is to discuss some aspects of the classification of juvenile dermatitis herpetiformis on the basis of a case report. CASE REPORTA 6-year-old boy was sent for consultation to our clinic with a history of bullae on the scalp, on the face, around the nose, behind the ears, followed by lesions on the scrotum and in the inguinal regions. His health was not impaired, and apparently the lesions were not pruritic.On first examination no bullae could be detected on the skin. However, a fortnight later a group of bullae developed on the left side of the scrotum and in the left inguinal region. Some days later a few bullae appeared around the nasal orifices and on the upper lip, followed by a few solitary bullae on the trunk and extremities. All bullae appeared on normal skin or on a slightly erythematous base; their mean diameter was 0-5-1 cm. The patient received no treatment at the time of investigation. Later he was treated with sulphapyridine with satisfactory results. Laboratory resultsESR 12 mm in i h; Hb 6,8 mmol/1; WBC 6500; eosinophils 3%; red blood cells, mild hypochromia. Haptoglobin, normal. Total serum proteins, normal. Serum electrophoresis, normal. Immunoelectrophoresis, IgA slightly decreased. Urine: no albumin sugar, or abnormal deposits. Faeces: normal colour and consistency. Glucose tolerance curve, normal.

show abstract

Section: Discussionmentioning

confidence: 95%

Juvenile pemphigoid

Faber

Joost

1973

Br J Dermatol

View full text Add to dashboard Cite

show abstract

“…As in DH of adults, there are intestinal changes in children also, and in two of our cases there were even the manifestations of coeliac disease. And again as in adults, treatment with sulphones or sulphapyridine is as a rule effective in children and a gluten-free diet produces distinct improvement (Fry et al, 1973)-It is similarly indubitable that children do develop bullous lesions corresponding clinically and histologically (Kim & Winkelmann, 1961) as well as immunopathologically to BP of adults (Bean, Good & Windhorst, 1970;Fincher, Dupree& Bean, 1971;Jablonska et aL, 1971;Jordon et ah, 1973;Chorzelski et al, 1975;Skeete & Greaves, 1976;Piamphongsant & Chaikiftisilpa, 1977;Bean, Jablonska & Chorzelski, 1978).…”

Section: Discussionmentioning

confidence: 99%

IgA linear dermatosis of childhood (chronic bullous disease of childhood)

Chorzelski¹,

Jabłońska²

1979

Br J Dermatol

View full text Add to dashboard Cite

SUMMARY Of twenty‐seven cases of subepidermal blistering disease of children twelve corresponded clinically, histologically and immunologically to dermatitis herpetiforms of adults, six to bullous pemphigoid, and eight to chronic Bullous disease of childhood (CBDC), i.e. IgA linear dermatosis. This latter disease seems to be a distinct entity, different from both dermatitis herpetiformis and Bullous pemphigoid, and is characterized immunopathologically by linear IgA deposits at the basement membrane zone. These cases usually do not show intestinal involvement and respond well to combined treatment with sulphones and corticosteroids, whereas sulphones or sulphapyridine alone are, even in very high doses, not sufficient for full control of the disease. CBDC or IgA linear dermatosis of childhood may be regarded as a counterpart of IgA linear dermatosis of adults.

show abstract

“…The diagnosis was suggested in this case, the sixth child with BP to be studied at St John's Hospital, by the presence of a widespread erythematous and vesiculo-bullous eruption and confirmed by histology and immunofiuorescence. Fever may be present in children with BP particularly those who have extensive disease, and oral lesions when they occur can cause considerable pain and feeding difficulty (Fincher, Dupree & Bean, 1971;Esterly et al, 1973;Robison & Odom, 1978). The patient described here was dehydrated, had lost some weight and had marked blood eosinophilia (39,ooo/mm3).…”

Section: Commentmentioning

confidence: 73%

“…BP in childhood has a prolonged course and tends to relapse in spite of treatment. Large doses of prednisolone (30-120 mg daily) are often required to control the disease (Bean et al, 1970;Fincher et al, 1971;Esterly et al, 1973;Robison & Odom, 1978;Chorzelski & Jablonska, 1979) and one of our patients needed as much as 500 mg prednisolone daily (Skeete & Greaves, 1976). However, spontaneous remissions may occur (Robison & Odom, 1978;Piamphongsant, Chaikittisilpa & KuUivanijaya, 1977) and in some cases the eruption can be controlled by either dapsone or sulphapyridine alone (Piamphongsant et al, 1979;Marsden, 1982).…”

Section: Commentmentioning

confidence: 91%

Bullous pemphigoid in a child

Marsden

1983

Clin Exp Dermatol

View full text Add to dashboard Cite

Bullous pemphigoid in childhood. Immunofluorescent studies

Cited by 26 publications

References 0 publications

Juvenile pemphigoid

Juvenile pemphigoid

IgA linear dermatosis of childhood (chronic bullous disease of childhood)

Bullous pemphigoid in a child

Contact Info

Product

Resources

About