1977
DOI: 10.1001/archderm.113.8.1043
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Bullous pemphigoid. Clinical and immunologic follow-up after successful therapy

Abstract: Thirty-six patients with bullous pemphigoid (BP) have been periodically evaluated for four years. This study demonstrates that BP may occur in a transient predominantly localized form that remits spontaneously, and most BP patients after successful therapy remain in prolonged clinical remission. In this study, all patients with active or recurrent disease had IgG and/or C3 basement membrane zone (BMZ) deposition. Serum anti-BMZ antibodies was an inconstant feature. In most instances, clinical remission of BP w… Show more

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Cited by 142 publications
(85 citation statements)
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“…There are few data in the literature on the prognosis of BP. In previous studies, death rates were usually lower than in the present one: 6% at 2 years, 6 19% at 1 year, 10 28% at 3 years, 9 30% at 3 years, 7 and 40% at 1 year. 8 All previous studies were on smaller numbers of patients and some may have included selected patients.…”
Section: Commentcontrasting
confidence: 64%
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“…There are few data in the literature on the prognosis of BP. In previous studies, death rates were usually lower than in the present one: 6% at 2 years, 6 19% at 1 year, 10 28% at 3 years, 9 30% at 3 years, 7 and 40% at 1 year. 8 All previous studies were on smaller numbers of patients and some may have included selected patients.…”
Section: Commentcontrasting
confidence: 64%
“…However, the older age of our patients was the most probable explanation for the observed differences. The mean (±SD) age of patients included in the present study was 79±11 years in comparison with 70 years, 6 74 years, 10 75 years, 8 and 79 years 9 in previous series. Our patients had been referred to university hospitals.…”
Section: Commentmentioning
confidence: 44%
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“…5 Histopathologic examination shows a picture of subepidermal bullae with eosinophils, and direct immunofluorescence studies on the perileisonal skin or indirect immunofluorescence studies using the patient's serum can confirm the diagnosis of BP. 6,7 Systemic and potent topical corticosteroids are the primary treatment of BP. 8 Several studies indicate an increase in mortality rates after the diagnosis of BP.…”
mentioning
confidence: 99%
“…As auto immune diseases are sometimes triggered by drugs and infections, they may form a causative environment for pemphigoid as a result of cross-reactivity with antigens in the basement membrane. No infectious disorder has been definitively associated with pemphigoid; however, antibodies against hepatitis B, and C, Helicobacter pylori, Toxoplasmosis, and cytomegalovirus were more prevalent among patients with pemphigoid disease [16] .…”
Section: Pathogenesismentioning
confidence: 99%