Bullous and Hemorrhagic Lesions

Kikuchi, Arata; Kawahara, Yoshie; Okamoto, S; Ikeda, Yasuo; Nishikawa, Takeji

doi:10.1001/archderm.135.1.81

Cited by 15 publications

(16 citation statements)

References 23 publications

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“…Secondly, despite extensive involvement of our patient’s truncal skin, the genital skin was spared. Thirdly, most cases of BLSA present with haemorrhage within the blisters, 3 a feature that was absent in our case.…”

Section: Reportmentioning

confidence: 44%

“…The first clinical description of LSA as an inflammatory dermatosis commonly affecting the female genitalia was given by Hallopeau, 1 and Darier 2 gave the first account of its histological features. BLSA is a rare variant of LSA that is thought to result from extensive vacuolar degeneration of the epidermal basal layer and is often accompanied by disruption and loss of collagen support of the dermal capillaries, resulting in haemorrhage within the bullae 3 …”

Section: Reportmentioning

confidence: 99%

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Extensive bullous lichen sclerosus with scarring alopecia

Madan

Cox

2009

Clinical and Experimental Dermatology

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We describe details of a very rare variant of lichen sclerosus in an elderly man. This pattern was characterized by involvement of most of the body surface by bullae, erosions and scarring, including scarring alopecia. Our patient responded to topical corticosteroids and doxycycline. Borrelia spp. have been implicated in a previous case of this variant, but we could not find any evidence of this in our patient.

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Section: Reportmentioning

confidence: 44%

Section: Reportmentioning

confidence: 99%

Extensive bullous lichen sclerosus with scarring alopecia

Madan

Cox

2009

Clinical and Experimental Dermatology

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“…Evidence suggests that lichen sclerosus may be genetic and immunologically linked, because it is associated with specific human leukocyte antigen types and other autoimmune diseases such as thyroid disease, alopecia areata, and pernicious anemia . Type 1 diabetes is found in 1% of patients and in 4.5% of first‐degree relatives . An infectious etiology has been suggested in the bullous variant, with some reports proposing a link with Borrelia and hepatitis C .…”

Section: Discussionmentioning

confidence: 99%

Extragenital Bullous Lichen Sclerosus in a Pediatric Patient: A Case Report and Literature Review

Shiver

Papasakelariou

Brown

et al. 2012

Pediatric Dermatology

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A 14-year-old girl presented with a 1-year history of a pruritic, bullous lesion on her posterior neck. A biopsy revealed bullous lichen sclerosus. Although unusual, this bullous variant of lichen sclerosus is well recognized in the adult literature, but extragenital bullous and hemorrhagic lesions are rare in children. A review of this case and the literature describes the clinical features, pathophysiology, and treatment options for this extragenital bullous variant in an effort to raise awareness of this rare clinical presentation.

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“…Hemorrhagic blisters have rarely been described developing in the background of either genital or extragenital lichen sclerosus. Such lesions have invariably been designated clinically as telangiectatic, hemorrhagic or bullous lichen sclerosus 5–8 …”

Section: Discussionmentioning

confidence: 99%

Angiokeratoma‐like changes in extragenital and genital lichen sclerosus

Luzar¹,

Neil

Calonje³

2009

J Cutan Pathol

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Hemorrhagic blisters have rarely been described developing in the background of either genital or extragenital lichen sclerosus and have invariably been designated clinically as telangiectatic, hemorrhagic or bullous lichen sclerosus. We describe three patients with extragenital and genital lichen sclerosus, who presented clinically with hemorrhagic plaques and/or papules. In addition to the classical histology of lichen sclerosus, dilated, congested and focally thrombosed vascular channels lined by flat endothelium were seen within the sclerotic dermal collagen. They were in close proximity to and even in contact with the overlying epidermis and thus mimicked an angiokeratoma. Angiokeratoma-like changes in lichen sclerosus represent secondary features because of damage to the dermis by lichen sclerosus and are characterized histologically by ectatic thin-walled vascular spaces in the papillary dermis intimately associated with the epidermis. Increased venous pressure, local trauma, degenerative changes in the elastic tissue of the vessel wall and/or surrounding supportive tissue, as well as abnormalities in the extracellular protein network, appear to be implicated in their pathogenesis.

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Bullous and Hemorrhagic Lesions

Cited by 15 publications

References 23 publications

Extensive bullous lichen sclerosus with scarring alopecia

Extensive bullous lichen sclerosus with scarring alopecia

Extragenital Bullous Lichen Sclerosus in a Pediatric Patient: A Case Report and Literature Review

Angiokeratoma‐like changes in extragenital and genital lichen sclerosus

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