Bufadienolides from the southern African Drimia depressa (Hyacinthaceae: Urgineoideae)

Crouch, Neil R.; Langlois, A.; Mulholland, Dulcie A.

doi:10.1016/j.phytochem.2007.04.003

Cited by 13 publications

(10 citation statements)

References 2 publications

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“…The OH-14 position was therefore designated as β. In addition, the H-7β signal at δ H 2.08 was assigned as β-equatorial due to deshielding from OH-14 [32]. Thus, compound 1 was proposed as 1β,3β,5β,14β-tetrahydroxy-19-oxocard-20(22)-en- The presence of the α-pyrone system was also deduced from the UV absorption at 300 nm and the strong carbonyl IR absorption at 1699 cm −1 [6].…”

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confidence: 96%

Cardenolides and Bufadienolide Glycosides from Kalanchoe tubiflora and Evaluation of Cytotoxicity

et al. 2013

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Two new cardenolides, kalantubolide A (1) and kalantubolide B (2), and two bufadienolide glycosides, kalantuboside A (3) and kalantuboside B (4), as well as eleven known compounds were isolated and characterized from the EtOH extract of Kalanchoe tubiflora. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses including HMQC, HMBC, and NOESY. Biological evaluation indicated that cardenolides (1-2) and bufadienolide glycosides (3-7) showed strong cytotoxicity against four human tumor cell lines (A549, Cal-27, A2058, and HL-60) with IC50 values ranging from 0.01 µM to 10.66 µM. Cardenolides (1-2) also displayed significant cytotoxicity toward HL-60 tumor cell line. In addition, compounds 3, 4, 5, 6, and 7 blocked the cell cycle in the G2/M-phase and induced apoptosis in HL-60 cells.

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confidence: 96%

Cardenolides and Bufadienolide Glycosides from Kalanchoe tubiflora and Evaluation of Cytotoxicity

et al. 2013

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“…5–9 The genus Urginea has been explored by other investigators, and in addition four bufadienolides were isolated from Drimia depressa , a botanical synonym of Urginea depressa. 10,11 These previous studies did not however report any biological data, and so the extract of U. depressa was selected for bioassay-guided fractionation to isolate its bioactive components.…”

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confidence: 99%

Antiproliferative Homoisoflavonoids and Bufatrienolides from Urginea depressa

et al. 2013

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Investigation of the South African plant Urginea depressa Baker (Asparagaceae Juss.) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the six new homoisoflavonoids urgineanins A-F (1 - 6), the two known bufatrienolides 7 and 9, and the new bufatrienolides urginins B and C (8 and 10). Structures were elucidated based on analysis of their 1D and 2D NMR spectra, electronic circular dichroism, and mass spectrometric data. Five of the six new homoisoflavonoids had good antiproliferative activity against the A2780 ovarian cancer, A2058 melanoma, and H522-T1 human non-small cell lung cancer cells, and urgineanin A (1) had submicromolar activity against all three cell lines. The four bufatrienolides 7 – 10 had strong antiproliferative activity against the same cell line, with IC50 values of 24.1, 11.2, 111 and 40.6 nM, respectively.

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“…The sugar moiety was deduced to be galactose upon comparison of the 1 H-NMR and 13 C-NMR values with those in literature. [22–24] Hence, the identity of 3 was established.…”

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confidence: 99%

Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis

et al. 2010

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Alpinia purpurata or red ginger was studied for its phytochemical constituents as part of our growing interest on Philippine Zingiberaceae plants that may exhibit antimycobacterial activity. The hexane and dichloromethane subextracts of the leaves were fractionated and purified using silica gel chromatography to afford a mixture of C28–C32 fatty alcohols, a 3-methoxyflavone and two steroidal glycosides. The two latter metabolites were spectroscopically identified as kumatakenin (1), sitosteryl-3-O-6-palmitoyl-β-D-glucoside (2) and b-sitosteryl galactoside (3) using ultraviolet (UV), infrared (IR), electron impact mass spectrometer (EIMS) and nuclear magnetic resonance (NMR) experiments, and by comparison with literature data. This study demonstrates for the first time the isolation of these constituents from A. purpurata. In addition to the purported anti-inflammatory activity, its phytomedicinal potential to treat tuberculosis is also described.

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Bufadienolides from the southern African Drimia depressa (Hyacinthaceae: Urgineoideae)

Cited by 13 publications

References 2 publications

Cardenolides and Bufadienolide Glycosides from Kalanchoe tubiflora and Evaluation of Cytotoxicity

Cardenolides and Bufadienolide Glycosides from Kalanchoe tubiflora and Evaluation of Cytotoxicity

Antiproliferative Homoisoflavonoids and Bufatrienolides from Urginea depressa

Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis

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