Budesonide nebulization in the treatment of neonatal ventilator associated pneumonia

Abstract

Objective:To investigate the clinical effect of budesonide nebulization in the treatment of ventilator associated pneumonia of newborns and its safety.Methods:Forty-five newborns who had ventilator associated pneumonia and were admitted into the Binzhou People’s Hospital between May 2014 and May 2015 were selected and included as an observation group. Moreover, another forty-five newborns who had ventilator associated pneumonia but did not undergo budesonide treatment in 2014 were randomly selected and included as a control group. Patients in the observation group were given budesonide suspension nebulization in addition to the conventional treatment. The evaluation indicators for therapeutic effect were compared between the two groups. The changes of head circumference, height and weight and death rate were observed by follow up after treatment.Results:The mechanical ventilation time, time for recovering from chest X-ray scan and hospitalization time of patients in the observation group were shorter than that of the control group, and the difference had statistical significance (P<0.05). The oxygen index of the patients in the observation group was significantly improved compared to that of the control group, and the difference had statistical significance (P<0.05). Patients in the two groups were followed up for six months after discharge. The head circumference, height and weight of the patients in the observation group in the 3rd and 6th month were compared to those of the control group, suggesting no significant differences (P>0.05). The cumulative death rate of the observation group in the 6th month after treatment was significantly lower than that of the control group, and the difference had statistical significance (P<0.05).Conclusion:Treating ventilator associated pneumonia of newborns with budesonide nebulization can effectively shorten mechanical ventilation time, time for recovering from chest X-ray scan and hospitalization time, improve pulmonary diffusion function and reduce the death rate, without affecting the growth and development of patients in the future.

Efficacy and safety of nebulized drugs in the treatment of non-severe mycoplasma pneumoniae pneumonia in children - a network meta-analysis

“…Among the nebulized drugs included in this study, budesonide is a glucocorticoid with anti-inflammatory properties that reduces airway spasm and exerts immunomodulatory effects ( Li et al, 2017 ). The results demonstrated that, compared to AZM, the combination of budesonide and AZM significantly reduced the incidence of adverse events.…”

Efficacy and safety of nebulized drugs in the treatment of non-severe mycoplasma pneumoniae pneumonia in children - a network meta-analysis

“…Among the nebulized drugs included in this study, budesonide is a glucocorticoid with anti-inflammatory properties that reduces airway spasm and exerts immunomodulatory effects ( Li et al, 2017 ). The results demonstrated that, compared to AZM, the combination of budesonide and AZM significantly reduced the incidence of adverse events.…”

Meta-analysis of combined azithromycin and inhaled budesonide treatment for Chinese pediatric patients with mycoplasma pneumonia

“…Budesonide, an unhalogenated glucocorticoid, has the ability to decrease vascular permeability, suppress mucus secretion, and alleviate edema and spasms. [ 41 , 42 ] When nebulized and inhaled, budesonide can distribute throughout the entire lung, proving highly effective in addressing local inflammation. [ 41 , 42 ] In China, budesonide nebulize is one of the most regularly used medications for the lavage solution during bronchoscopic alveolar lavage, with fewer reports coming from other countries.…”

“…[ 41 , 42 ] When nebulized and inhaled, budesonide can distribute throughout the entire lung, proving highly effective in addressing local inflammation. [ 41 , 42 ] In China, budesonide nebulize is one of the most regularly used medications for the lavage solution during bronchoscopic alveolar lavage, with fewer reports coming from other countries. [ 43 ] The objective of this study is to assess the effectiveness and safety of budesonide as an adjunctive therapy to azithromycin in the treatment of Mycoplasma pneumonia in Chinese pediatric patients, to offer a solid theoretical foundation for the clinical application of budesonide.…”

Clinical efficacy of budesonide combined with acetylcysteine in the treatment of mycoplasma pneumonia infection

“…38 It has been widespreadly applied in the clinical treatment of pediatric pneumonia. 39 Acetylcysteine has certain antioxidant damage, and it is rich in free sulfhydryl (-SH) groups, which can break the mucin disulfide bond in sputum, reduce the viscosity of sputum, promote sputum discharge as soon as possible, and quickly relieve the cough and sputum symptoms of children. 40 A recent clinical study has reported that Nacetylcysteine combination can improve the treatment of bronchopneumonia in children and quick relief of lung rales.…”

“…Budesonide is a glucocorticoid drug, which can rapidly play the anti‐immune function and anti‐inflammatory effect 38 . It has been widespreadly applied in the clinical treatment of pediatric pneumonia 39 . Acetylcysteine has certain antioxidant damage, and it is rich in free sulfhydryl (‐SH) groups, which can break the mucin disulfide bond in sputum, reduce the viscosity of sputum, promote sputum discharge as soon as possible, and quickly relieve the cough and sputum symptoms of children 40 .…”

Efficacy and safety of nebulized drugs in the treatment of non-severe mycoplasma pneumoniae pneumonia in children - a network meta-analysis

“…Among the nebulized drugs included in this study, budesonide is a glucocorticoid with anti-inflammatory properties that reduces airway spasm and exerts immunomodulatory effects ( Li et al, 2017 ). The results demonstrated that, compared to AZM, the combination of budesonide and AZM significantly reduced the incidence of adverse events.…”

Meta-analysis of combined azithromycin and inhaled budesonide treatment for Chinese pediatric patients with mycoplasma pneumonia

“…Budesonide, an unhalogenated glucocorticoid, has the ability to decrease vascular permeability, suppress mucus secretion, and alleviate edema and spasms. [ 41 , 42 ] When nebulized and inhaled, budesonide can distribute throughout the entire lung, proving highly effective in addressing local inflammation. [ 41 , 42 ] In China, budesonide nebulize is one of the most regularly used medications for the lavage solution during bronchoscopic alveolar lavage, with fewer reports coming from other countries.…”

“…[ 41 , 42 ] When nebulized and inhaled, budesonide can distribute throughout the entire lung, proving highly effective in addressing local inflammation. [ 41 , 42 ] In China, budesonide nebulize is one of the most regularly used medications for the lavage solution during bronchoscopic alveolar lavage, with fewer reports coming from other countries. [ 43 ] The objective of this study is to assess the effectiveness and safety of budesonide as an adjunctive therapy to azithromycin in the treatment of Mycoplasma pneumonia in Chinese pediatric patients, to offer a solid theoretical foundation for the clinical application of budesonide.…”

Clinical efficacy of budesonide combined with acetylcysteine in the treatment of mycoplasma pneumonia infection

“…38 It has been widespreadly applied in the clinical treatment of pediatric pneumonia. 39 Acetylcysteine has certain antioxidant damage, and it is rich in free sulfhydryl (-SH) groups, which can break the mucin disulfide bond in sputum, reduce the viscosity of sputum, promote sputum discharge as soon as possible, and quickly relieve the cough and sputum symptoms of children. 40 A recent clinical study has reported that Nacetylcysteine combination can improve the treatment of bronchopneumonia in children and quick relief of lung rales.…”

“…Budesonide is a glucocorticoid drug, which can rapidly play the anti‐immune function and anti‐inflammatory effect 38 . It has been widespreadly applied in the clinical treatment of pediatric pneumonia 39 . Acetylcysteine has certain antioxidant damage, and it is rich in free sulfhydryl (‐SH) groups, which can break the mucin disulfide bond in sputum, reduce the viscosity of sputum, promote sputum discharge as soon as possible, and quickly relieve the cough and sputum symptoms of children 40 .…”

Efficacy and safety of nebulized drugs in the treatment of non-severe mycoplasma pneumoniae pneumonia in children - a network meta-analysis

“…Among the nebulized drugs included in this study, budesonide is a glucocorticoid with anti-inflammatory properties that reduces airway spasm and exerts immunomodulatory effects ( Li et al, 2017 ). The results demonstrated that, compared to AZM, the combination of budesonide and AZM significantly reduced the incidence of adverse events.…”

Meta-analysis of combined azithromycin and inhaled budesonide treatment for Chinese pediatric patients with mycoplasma pneumonia

“…Budesonide, an unhalogenated glucocorticoid, has the ability to decrease vascular permeability, suppress mucus secretion, and alleviate edema and spasms. [ 41 , 42 ] When nebulized and inhaled, budesonide can distribute throughout the entire lung, proving highly effective in addressing local inflammation. [ 41 , 42 ] In China, budesonide nebulize is one of the most regularly used medications for the lavage solution during bronchoscopic alveolar lavage, with fewer reports coming from other countries.…”

“…[ 41 , 42 ] When nebulized and inhaled, budesonide can distribute throughout the entire lung, proving highly effective in addressing local inflammation. [ 41 , 42 ] In China, budesonide nebulize is one of the most regularly used medications for the lavage solution during bronchoscopic alveolar lavage, with fewer reports coming from other countries. [ 43 ] The objective of this study is to assess the effectiveness and safety of budesonide as an adjunctive therapy to azithromycin in the treatment of Mycoplasma pneumonia in Chinese pediatric patients, to offer a solid theoretical foundation for the clinical application of budesonide.…”

Clinical efficacy of budesonide combined with acetylcysteine in the treatment of mycoplasma pneumonia infection

“…38 It has been widespreadly applied in the clinical treatment of pediatric pneumonia. 39 Acetylcysteine has certain antioxidant damage, and it is rich in free sulfhydryl (-SH) groups, which can break the mucin disulfide bond in sputum, reduce the viscosity of sputum, promote sputum discharge as soon as possible, and quickly relieve the cough and sputum symptoms of children. 40 A recent clinical study has reported that Nacetylcysteine combination can improve the treatment of bronchopneumonia in children and quick relief of lung rales.…”

“…Budesonide is a glucocorticoid drug, which can rapidly play the anti‐immune function and anti‐inflammatory effect 38 . It has been widespreadly applied in the clinical treatment of pediatric pneumonia 39 . Acetylcysteine has certain antioxidant damage, and it is rich in free sulfhydryl (‐SH) groups, which can break the mucin disulfide bond in sputum, reduce the viscosity of sputum, promote sputum discharge as soon as possible, and quickly relieve the cough and sputum symptoms of children 40 .…”