Buccal films: A review of therapeutic opportunities, formulations &amp; relevant evaluation approaches

Shipp, Lewis; Liu, Fang; Kerai, Laxmi; Okwuosa, Tochukwu Chijioke

doi:10.1016/j.jconrel.2022.10.058

Cited by 29 publications

(32 citation statements)

References 198 publications

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“…The majority of nonsteroidal anti-inflammatory drugs pose GI concerns upon repeated oral administration. Administration of pharmaceuticals via the buccal route circumvents the hepatic first-pass effect and bypasses the GI tract. , The mucoadhesive nature is attained by hydrophilic polymers due to their swelling behavior and interaction with the buccal mucosa (Figure ). Examples of such swellable polymers include HPMC, PVP, hydroxyethyl cellulose (HEC), hydroxypropyl cellulose (HPC), carboxymethyl cellulose (CMC), sodium carboxymethyl cellulose (SCMC), and chitosan. − …”

Section: Type Of Tabletized Nanomedicinementioning

confidence: 99%

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Tiwari,

Kolli,

Chauhan

et al. 2024

ACS Nano

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The limitations of conventional therapeutic treatments prevailed in the development of nanotechnology-based medical formulations, termed nanomedicine. Nanomedicine is an advanced medicine that often consists of therapeutic agent(s) embedded in biodegradable or biocompatible nanomaterial-based formulations. Among nanomedicine approaches, tablet (oral) nanomedicine is still under development. In tabletized nanomedicine, the dynamic interplay between nanoformulations and the intricate milieu of the gastrointestinal tract simulates a pivotal role, particularly accentuating the influence exerted upon the luminal, mucosal, and epithelial cells. In this work, we document the perspectives and opportunities of nanoformulations toward the development of tabletized nanomedicine. This review also unveils the notion of integrating nanomedicine within a tablet formulation, which facilitates the controlled release of drugs, biomolecules, and agent(s) from the formulation to achieve a better therapeutic response. Finally, an attempt was made to explore current trends in nanomedicine technology such as bacteriophage, probiotic, and oligonucleotide tabletized nanomedicine and the combination of nanomedicine with imaging agents, i.e., nanotheranostics.

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Section: Type Of Tabletized Nanomedicinementioning

confidence: 99%

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Tiwari,

Kolli,

Chauhan

et al. 2024

ACS Nano

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“…Mucoadhesive polymers are required to provide optimal adherence to the buccal mucosa. The most commonly used ones are Methyl Cellulose (MC), Carboxymethyl Cellulose (CMC), Ethyl Cellulose (EC), Hydroxyethyl Cellulose (HEC), Hydroxypropyl Methyl Cellulose (HPMC), Hydroxypropyl Cellulose (HPC), Polyvinyl Alcohol (PVA), and Polyvinyl Pyrrolidone (PVP) [1,4,63,66].…”

Section: Oral Films As Innovative Dosage Formsmentioning

confidence: 99%

“…Due to high patient compliance, over 70% of commercially available drugs are formulated for oral administration. A relatively new formulation consists of oral films (OF) adapted for buccal drug administration, avoiding gastric pH, first-pass metabolism, and enzymatic degradation of active pharmaceutical ingredients (API), and providing effective therapy for patients with special needs [1][2][3]. Oral films are novel drug delivery systems containing active ingredients in water-soluble polymer matrixes [4].…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

Ozon,

Sarbu,

Popovici

et al. 2023

Processes

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The interest in buccal drug delivery is under consideration due to some distinct properties compared to the traditional pharmaceutical formulations for oral administration: significantly higher bioavailability, a faster absorption rate of the drug, and substantial compliance for special needs patients. Oral films are obtained through various technologies, from conventional tools to 3D and 4D printing approaches. This minireview aims to describe the current additive manufacturing technologies in oral film fabrication, display their advantages and limitations, and discuss various formulation strategies. It also provides advanced data regarding synthetic and natural polymers used in 3D printing technologies for oral films. Moreover, it shows the most recent studies with 3D-printed orodispersible films and mucoadhesive buccal films manufactured through previously analyzed methods. Finally, conclusions and future perspectives are also briefly summarized.

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“…Buccal drug delivery offers great advantages over other routes including oral and parenteral administrations 10 . It is a non-invasive, painless, and convenient method of drug administration 11 .…”

Section: Introductionmentioning

confidence: 99%

“…The 3D printers commonly used in the pharmaceutical eld are stereolithography (SLA) 30 , inkjet, semi-solid extrusion, fused deposition modelling (FDM), binder-jetting, and selective laser sintering (SLS) printing 8,9 . In semi-solid extrusion, objects are created by step-by-step deposition of layers of feed material, often paste or gel 10 . It offers several advantages, including the ability to print at low temperatures, fast printing speed, and meeting quality requirements 11 .…”

Section: Introductionmentioning

confidence: 99%

Harnessing the Synergistic Potential of 3D Printed Buccal Films and Nanostructured Lipid Carriers (NLCs) For Personalised Cannabidiol Delivery

Abdella

Kim

Afinjuomo

et al. 2023

Preprint

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Introduction: Cannabidio(CBD) has been recognized for its numerous therapeutic benefits, such as neuroprotection, anti-inflammatory effects, and cardioprotection. However, CBD has some limitations, including unpredictable pharmacokinetics and low oral bioavailability. To overcome the challenges associated with CBD delivery, we employed Design of Experiments (DoE), lipid carriers, and 3D printing techniques to optimize and develop buccal film loaded with CBD-NLCs. Methods: Three-factor Box-Behnken Design was carried out to optimise the NLCs and analyse the effect of independent factors on dependent factors. The emulsification-ultrasonication technique was used to prepare the NLCs. A pressure-assisted micro-syringe printing technique was used to produce the films. The produced films were studied for physicochemical, and mechanical properties, release profiles, and predicted in vivo performance. Results: The observed particle size of the NLCs ranged from 12.17 to 84.91nm whereas the PDI varied from 0.099 to 0.298. Lipid and sonication time positively affected the particle size whereas the surfactant concentration was inversely related. CBD was incorporated into the optimal formulation and the observed particle size, PDI, and zeta potential for the CBD-NLCs were 94.2 ±0.47nm, 0.11± 0.01 and−11.8 ± 0.52 mV. Hydroxyethyl cellulose (HEC)-based gel containing the CBD-NLCs was prepared and used as a feed for 3D printing. The CBD-NLCs film demonstrated a two-phase in vitro release profile, wherein an initial burst release of 47% occurred within the first 2h. The predicted AUC0–10h, Cmax, and Tmax were 201.5µg·h/L, 0.74 µg/L, and 1.28 h for a film with 0.4 mg of CBD, respectively. Conclusion: The finding demonstrates that a buccal film of CBD-NLCs can be fabricated using 3D printing.

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Buccal films: A review of therapeutic opportunities, formulations & relevant evaluation approaches

Cited by 29 publications

References 198 publications

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

Harnessing the Synergistic Potential of 3D Printed Buccal Films and Nanostructured Lipid Carriers (NLCs) For Personalised Cannabidiol Delivery

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