BubR1 and brain aging

Hussaini, S. M. Qasim; Jang, Mi Hyeon

doi:10.18632/aging.101300

Cited by 1 publication

(1 citation statement)

References 6 publications

(7 reference statements)

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“…Interestingly, arterial wall thickness were reduced in loss-of-BubR1 mice, with increased fibrosis and reduced elastic properties favouring the development of cardiovascular diseases [ 240 ]. Recently, it has been demonstrated an important role of BubR1 in the regulation of neuronal maturation, showing that during age-related cognitive disability the level of this mitotic checkpoint kinase, decreases with natural aging inducing elderly features and alteration of central nervous system [ 243 ].…”

Section: Genetic Impact On Agingmentioning

confidence: 99%

The Impact of Aging on Cardio and Cerebrovascular Diseases

Izzo

Carrizzo

Alfano

et al. 2018

IJMS

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A growing number of evidences report that aging represents the major risk factor for the development of cardio and cerebrovascular diseases. Understanding Aging from a genetic, biochemical and physiological point of view could be helpful to design a better medical approach and to elaborate the best therapeutic strategy to adopt, without neglecting all the risk factors associated with advanced age. Of course, the better way should always be understanding risk-to-benefit ratio, maintenance of independence and reduction of symptoms. Although improvements in treatment of cardiovascular diseases in the elderly population have increased the survival rate, several studies are needed to understand the best management option to improve therapeutic outcomes. The aim of this review is to give a 360° panorama on what goes on in the fragile ecosystem of elderly, why it happens and what we can do, right now, with the tools at our disposal to slow down aging, until new discoveries on aging, cardio and cerebrovascular diseases are at hand.

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Section: Genetic Impact On Agingmentioning

confidence: 99%