2021
DOI: 10.1590/1678-9199-jvatitd-2020-0188
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Luiza Helena Gremski,
Fernando Hitomi Matsubara,
Hanna Câmara da Justa
et al.

Abstract: Accidents caused by the bites of brown spiders (Loxosceles) generate a clinical condition that often includes a threatening necrotic skin lesion near the bite site along with a remarkable inflammatory response. Systemic disorders such as hemolysis, thrombocytopenia, and acute renal failure may occur, but are much less frequent than the local damage. It is already known that phospholipases D, highly expressed toxins in Loxosceles venom, can induce most of these injuries. However, this spider venom has a great r…

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