Brown and beige fat: From molecules to physiology and pathophysiology

Carobbio, Stefania; Guénantin, Anne-Claire; Samuelson, Isabella; Bahri, Myriam; Vidal-Puig, António

doi:10.1016/j.bbalip.2018.05.013

Cited by 50 publications

(48 citation statements)

References 171 publications

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“…Although questions remain on the composition and origin of BAT in adult humans [ 27 , 28 ], it is generally believed that BAT is a novel target to combat human obesity and associated metabolic disorders. Here, we show the sEH expression pattern in the murine and human brown adipogenesis in vitro and the WAT and BAT fat in the DIO mice.…”

Section: Discussionmentioning

confidence: 99%

Soluble Epoxide Hydrolase Inhibition by t-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglycerides in Diet-Induced Obesity

Overby

Yang

et al. 2020

IJMS

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Brown adipose tissue (BAT) is an important target for obesity treatment and prevention. Soluble epoxide hydrolase (sEH) converts bioactive epoxy fatty acids (EpFAs) into less active diols. sEH inhibitors (sEHI) are beneficial in many chronic diseases by stabilizing EpFAs. However, roles of sEH and sEHI in brown adipogenesis and BAT activity in treating diet-induced obesity (DIO) have not been reported. sEH expression was studied in in vitro models of brown adipogenesis and the fat tissues of DIO mice. The effects of the sEHI, trans-4-{4-[3-(4-trifluoromethoxy-phenyl)-ureido]-cyclohexyloxy-benzoic acid (t-TUCB), were studied in vitro and in the obese mice via mini osmotic pump delivery. sEH expression was increased in brown adipogenesis and the BAT of the DIO mice. t-TUCB promoted brown adipogenesis in vitro. Although t-TCUB did not change body weight, fat pad weight, or glucose and insulin tolerance in the obese mice, it decreased serum triglycerides and increased protein expression of genes important for lipid metabolism in the BAT. Our results suggest that sEH may play a critical role in brown adipogenesis, and sEHI may be beneficial in improving BAT protein expression involved in lipid metabolism. Further studies using the sEHI combined with EpFA generating diets for obesity treatment and prevention are warranted.

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Section: Discussionmentioning

confidence: 99%

Soluble Epoxide Hydrolase Inhibition by t-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglycerides in Diet-Induced Obesity

Overby

Yang

et al. 2020

IJMS

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“…An important development over the past decade, although not on BAT as such, is the discovery of a third form of adipocyte—“brite” or “beige” (Petrovic et al, 2010 ; Wu et al, 2012 ; Carobbio et al, 2019 ). These fat cells contain UCP1, providing the potential for thermogenesis, and have some of the other molecular signatures of brown adipocytes (Petrovic et al, 2010 ; Wu et al, 2012 ).…”

Section: Recent Developments In Bat Physiologymentioning

confidence: 99%

Brown Adipose Tissue—A Therapeutic Target in Obesity?

Trayhurn

2018

Front. Physiol.

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“…Бурая жировая ткань активно изучается в последнее десятилетие [25][26][27][28][29][30], а «бежевые» адипоциты открыты лишь в 2012 г. [31,32].…”

Section: состояние проблемыunclassified

Type 2 diabetes and metabolic syndrome: identification of the molecular mechanisms, key signaling pathways and transcription factors aimed to reveal new therapeutical targets

Dedov¹,

Tkachuk²,

Gusev³

et al. 2018

Diabetes mellitus

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Type 2 diabetes mellitus (T2DM) is a socially important disease with only symptomatic therapy developed due to lack of knowledge about its pathogenesis and underlying mechanism. Insulin resistance (IR) is the first link of T2DM pathogenesis and results in decrease of ability of insulin to stimulate glucose uptake by target cells. Development of IR involves genetic predisposition, excessive nutrition, stress, obesity or chronic inflammation due to disruption of insulin signaling within cells. Molecular mechanisms and markers of IR are characterized rather poorly, which prevents early diagnosis and creation of preventive therapy. Euglycemic clamp test is still a golden standard for IR diagnosis in clinic. Hyperglycemia is a distant consequence of IR in which damaging effect of oxidative and carbonyl stress is realized and diagnosis of T2DM is stipulated. Molecular chaperones and small heat-shock proteins have a protective effect at the early stages of T2DM pathogenesis, preventing development of reticulum stress and apoptosis. Endothelial dysfunction is related to T2DM and its cardiovascular complications, however, it is unknown on which stage of pathogenesis these changes occur and what are their molecular inductors. Finally, transcriptional activity and adipogenic differentiation play an important role in formation of new fat depots from predecessor cells and activation of brown and beige fat demonstrating hypolipidemic and hypoglycemic properties. The aim of this study was investigation of pathophysiological mechanisms of development of IR and endothelial dysfunction, role of transcription factor Prep1 and small heat shock proteins, evaluation of novel methods of diagnostics of IR and therapeutic potential of brown and beige fat, determination of biotargets for new antidiabetic drugs.

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Brown and beige fat: From molecules to physiology and pathophysiology

Cited by 50 publications

References 171 publications

Soluble Epoxide Hydrolase Inhibition by t-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglycerides in Diet-Induced Obesity

Soluble Epoxide Hydrolase Inhibition by t-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglycerides in Diet-Induced Obesity

Brown Adipose Tissue—A Therapeutic Target in Obesity?

Type 2 diabetes and metabolic syndrome: identification of the molecular mechanisms, key signaling pathways and transcription factors aimed to reveal new therapeutical targets

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