Brown Algal Polyphenol and Its Pharmaceutical Properties

Vo, Thanh Sang; Ngo, Dai Hung; Kim, Se‐Kwon

doi:10.1007/978-981-13-8855-2_11

Cited by 4 publications

(3 citation statements)

References 133 publications

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“…ese activities are related to the presence of phenolic compounds, phlorotannins, pigments, tocopherols, polysaccharides, fatty acids, and peptides in the seaweed extracts [15,[20][21][22][23][24][25][26][27][28]. e main compounds reported as potent α-amylase and α-glucosidase inhibitors are as follows: phloroglucinol derivatives such as dieckol, 8,8′-bieckol, phlorofucofuroeckol, fucophloroethol, and phlorotannins with low PGU [23,25,[29][30][31], fucoidan [3,32,33], and oleic, linoleic, and eicosapentaenoic acids [24].…”

Section: Introductionmentioning

confidence: 99%

Nutraceutical Potential of Five Mexican Brown Seaweeds

Garza

Tapia‐Salazar

Maldonado-Muñiz

et al. 2019

BioMed Research International

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In search of pharmaceutically active products to control type 2 diabetes, five brown seaweeds (Silvetia compressa, Cystoseira osmundacea, Ecklonia arborea, Pterygophora californica, and Egregia menziesii) from the Northwest Mexican Pacific coast were investigated. Proximate composition and total polyphenol content (TPC) as phloroglucinol equivalents (PGE) were determined for the five seaweed powders and their respective hydroethanolic (1 : 1) extracts. Extracts were screened for their radical scavenging activity (DPPH and ORAC) and glycosidase inhibitory activity. HPLC-DAD, HPLC-MS-TOF, and ATR-FT-IR methodologies were used to identify the most abundant phlorotannins and sulfated polysaccharides in the extracts. Hydroethanolic extracts contained minerals (17 to 59% of the dry matter), proteins (4 to 9%), ethanol-insoluble polysaccharides (5.4 to 53%), nitrogen-free extract (NFE) (24.4 to 70.1%), lipids (5 to 12%), and TPC (2.6 to 47.7 g PGE per 100 g dry extract). S. compressa and E. arborea dry extracts presented the lowest ash content (26 and 17%, respectively) and had some of the highest phenolic (47.7 and 15.2 g PGE per 100 g extract), NFE (57.3 and 70.1%), and soluble polysaccharide (19.7 and 53%) contents. S. compressa and E. arborea extracts had the highest antioxidant activity (IC50 DPPH 1.7 and 3.7 mg mL−1; ORAC 0.817 and 0.801 mmol Trolox equivalent/g extract) and the highest α-amylase and α-glucosidase inhibitory capacities (IC50 940 and 1152 μg mL−1 against α-amylase and 194 and 647 μg mL−1 against α-glucosidase). The most abundant phlorotannins identified in the extracts were phloretol, fucophloroethol, and two- and three-phloroglucinol unit (PGU) phlorotannins. Laminarin, fucoidan, and alginate were among the sulfated polysaccharides identified in the extracts. The bioactivities of S. compressa and E. arborea extracts were mainly related with their contents of three PGU phlorotannins and sulfated polysaccharides (e.g., fucoidan, laminarin, and alginate). These results suggest S. compressa and E. arborea are potential candidates for food products and nutraceutical and pharmaceutical preparations, and as additives for diabetes management.

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Section: Introductionmentioning

confidence: 99%

Nutraceutical Potential of Five Mexican Brown Seaweeds

Garza

Tapia‐Salazar

Maldonado-Muñiz

et al. 2019

BioMed Research International

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“…Within the broad group of phytochemical compounds, whether from terrestrial or aquatic plants, phenols are of special interest due to their high bioactive capacity, being important antioxidants associated with beneficial effects on health. While the potential of marine algae for containing these compounds is well known, the studies focused on the extraction and characterization of their polyphenolic profiles, especially for brown algae, are still scarce [ 19 ]. As it is well known, phenols present a wide range of polarity and properties depending on their chemical structure.…”

Section: Resultsmentioning

confidence: 99%

Bioprospecting of Targeted Phenolic Compounds of Dictyota dichotoma, Gongolaria barbata, Ericaria amentacea, Sargassum hornschuchii and Ellisolandia elongata from the Adriatic Sea Extracted by Two Green Methods

et al. 2023

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The content of bioactive compounds in four brown and one red algae from the Adriatic Sea (Dictyota dichotoma, Gongolaria barbata, Ericaria amentacea, Sargassum hornschuchii and Ellisolandia elongata) is explored. The efficiency of two different extraction methods viz. ultrasound-assisted extraction (UAE) and matrix solid-phase dispersion (MSPD) to obtain the extracts rich in phenolic compounds was compared. The effect of the extraction solvent to modulate the phenolic profile was assessed. In general, the mixture ethanol/water in an isovolumetric proportion showed the best results. The total phenolic content (TPC) and antioxidant activity (AA), as well as the individual polyphenolic profile, were evaluated for five target algae. TPC values ranged between 0.2 mg GAE/g (for E. elongata) and 38 mg GAE/g (for S. hornschuchii). Regarding the quantification of individual polyphenols by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, the presence of a high number of hydroxybenzoic acid derivatives (mainly of 3- and 4-hydroxybenzoic acids) in all species was noted. In G. barbata their concentrations reached up to 500 mg/kg. IC50 values (ABTS assay) ranged between 44 mg/L (for S. hornschuchii) and 11,040 mg/L (for E. elongata). This work contributes to the in-depth characterization of these little-explored algae, showing their potential as a natural source of phenolic compounds.

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“…While alginates are usually commercialized to be used as thickening, gelling, and stabilizing agents in food, cosmetic and pharmaceutical industries, this alga also contains other bioactives, such as fucoidans that reduce the expression of the pro-inflammatory cytokines and have antioxidant, antimicrobial, and antitumor properties [ 122 ], and phenolic compounds to which are usually associated antioxidant properties [ 20 , 123 , 124 ]. An example of phenolic compounds identified in extracts of L. ochroleuca is the linear phlorethols, which may have ortho -, meta - or para -oriented biphenyl ether bridges or combinations such as triphlorethol C and acetylated tetraphlorethols A and B ( Figure 12 ) [ 125 , 126 ].…”

Section: Resultsmentioning

confidence: 99%

Up-to-Date Overview of the Use of Natural Ingredients in Sunscreens

et al. 2022

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The photoprotective skincare segment is in high demand to meet consumer concerns on UV-induced skin damage, with a recent trend towards sunscreen alternatives with a natural origin. In this study, the use of natural ingredients, either from terrestrial or marine origin, in a panel of 444 sunscreen commercial formulations (2021) was analyzed. Ingredients from terrestrial organisms represent the large majority found in the analyzed sunscreen formulations (48%), whereas marine ingredients are present only in 13% of the analyzed products. A deeper analysis regarding the most prevalent families of ingredients from terrestrial and marine organisms used as top ingredients is also presented, as well as their mechanisms of action. This study provides an up-to-date overview of the sunscreen market regarding the use of natural ingredients, which is of relevance for scientists involved in the development of new sunscreens to identify opportunities for innovation.

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Brown Algal Polyphenol and Its Pharmaceutical Properties

Cited by 4 publications

References 133 publications

Nutraceutical Potential of Five Mexican Brown Seaweeds

Nutraceutical Potential of Five Mexican Brown Seaweeds

Bioprospecting of Targeted Phenolic Compounds of Dictyota dichotoma, Gongolaria barbata, Ericaria amentacea, Sargassum hornschuchii and Ellisolandia elongata from the Adriatic Sea Extracted by Two Green Methods

Up-to-Date Overview of the Use of Natural Ingredients in Sunscreens

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