Brown adipose tissue‐derived exosomes improve polycystic ovary syndrome in mice via STAT3/GPX4 signaling pathway
Yu‐Qing Fang,
Han‐Ke Zhang,
Qiong‐Qiong Wei
et al.
Abstract:Polycystic ovary syndrome (PCOS) is associated with impaired adipose tissue physiology. Elevated brown adipose tissue (BAT) mass or activity has shown potential in the treatment of PCOS. In this study, we aimed to investigate whether BAT‐derived exosomes (BAT‐Exos), as potential biomarkers of BAT activity, exert similar benefits as BAT in the treatment of PCOS. PCOS was induced in female C57BL/6J mice orally administered 1 mg/kg of letrozole for 21 days. Subsequently, the animals underwent transplantation with… Show more
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