Bronchodilators and diuretics in children with bronchopulmonary dysplasia

Abstract

Pulmonary function tests (PFT) were obtained during the course of a self-controlled study of six children aged 5 to 43 months who had moderate to severe bronchopulmonary dysplasia (BPD). Changes after the administration of intravenous (IV) furosemide (2 mg/kg), inhaled isoproterenol (0.2 cc, 1:200), inhaled atropine sulfate (0.05 mg/kg), and a placebo were assessed. The study indicated the furosemide and atropine significantly (P less than 0.05) increased dynamic compliance (CL) for the group. A decrease in total pulmonary resistance (RL) and work of breathing (W) was observed after isoproterenol, although the responses were not significant (P = 0.08 and P = 0.09, respectively). It was speculated that pulmonary edema and increased vagal tone may contribute to small airway dysfunction in children who have BPD.

Diuretics use in the management of bronchopulmonary dysplasia in preterm infants: A systematic review

“…Three studies examined the effects of a combination of spironolactone and chlorothiazide, 8,19,22 2 studies examined the effects of a combination of spironolactone and hydrochlorothiazide 7,27 and 8 examined the effects of furosemide (Table 1). 5,9,21,[23][24][25][26][27] Every trial measured dynamic pulmonary compliance and pulmonary resistance and these measures were used as comparative tools in this review.…”

Response to bronchodilators in clinically stable 1-year-old patients with bronchopulmonary dysplasia

“…Logvino et al [12] measured pulmonary resistance in six BPD patients 4±43 months old and found no signi®cant change after administration of isoproterenol. Kao et al [10,11] reported two studies.…”

Pharmacotherapy in Bronchopulmonary Dysplasia: What Is the Evidence?

“…The use of salbutamol was shown to be effective in improving compliance and resistance in very low birth weight (VLBW) infants as early as the second week of life ( 162 ). Similarly, inhaled atropine has been shown to improve dynamic compliance in non-intubated patients with BPD ( 159 ).…”

“…Lungs of infants with BPD often have increased resistance and decreased compliance (157). The use of beta-agonists has been shown to reduce airway resistance in both intubated and non-intubated BPD patients and improve dynamic compliance and specific airway conductance in intubated BPD patients (158)(159)(160)(161). The use of salbutamol was shown to be effective in improving compliance and resistance in very low birth weight (VLBW) infants as early as the second week of life (162).…”