2010
DOI: 10.1136/thx.2009.120857
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Abstract: Background Expiratory flow limitation and lung hyperinflation promote cardiocirculatory perturbations that might impair O 2 delivery to locomotor muscles in patients with chronic obstructive pulmonary disease (COPD). The hypothesis that decreases in lung hyperinflation after the inhalation of bronchodilators would improve skeletal muscle oxygenation during exercise was tested. Methods Twelve non-or mildly hypoxaemic males (forced expiratory volume in 1 s (FEV 1 )¼38.5612.9% predicted; PaO 2 >60 mm Hg) underwen… Show more

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Cited by 58 publications
(60 citation statements)
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“…Authors concluded that unloading the respiratory muscles decreased their perfusion, allowing more blood flow to the skeletal muscles and a greater exercise power at the same total cardiac output (233). Additional studies, unloading the respiratory muscles by means of heliox breathing, proportional assisted ventilation and inhaled bronchodilators during constant-load exercise in COPD have suggested improved peripheral muscle oxygen delivery as that was either inferred by near-infrared spectroscopy-determined kinetic analysis of tissue oxygenation indices (31,35), or by decreasing approximately 30% to 40% the exercise-induced limb muscle fatigue (21). Faster cardiac-output kinetic responses following heliox and bronchodilator administration were also interpreted as an alleviation of disturbances imposed by the mechanics of breathing (31).…”
Section: Blood Flow Redistributionmentioning
confidence: 94%
“…Authors concluded that unloading the respiratory muscles decreased their perfusion, allowing more blood flow to the skeletal muscles and a greater exercise power at the same total cardiac output (233). Additional studies, unloading the respiratory muscles by means of heliox breathing, proportional assisted ventilation and inhaled bronchodilators during constant-load exercise in COPD have suggested improved peripheral muscle oxygen delivery as that was either inferred by near-infrared spectroscopy-determined kinetic analysis of tissue oxygenation indices (31,35), or by decreasing approximately 30% to 40% the exercise-induced limb muscle fatigue (21). Faster cardiac-output kinetic responses following heliox and bronchodilator administration were also interpreted as an alleviation of disturbances imposed by the mechanics of breathing (31).…”
Section: Blood Flow Redistributionmentioning
confidence: 94%
“…NIRS has been used to examine the effect of bronchodilators [46] and oxygen [47,48] administration on the improvement of attenuated oxygen delivery to the muscle in patients with chronic obstructive pulmonary disease (see [49] for review). NIRS has also been used to examine the effect of pharmacological treatment on blunted microvascular oxygen delivery to the muscle [50] and the effect of a rehabilitation programme on muscle oxygenation [51] in patients with chronic heart failure.…”
Section: (D) Examples Of Recent Advanced Near-infrared Spectroscopy Amentioning
confidence: 99%
“…NIRS technology has been applied to the study of a number of chronic health conditions, including patients with COPD. Such studies have investigated the impact of the pulmonary system limitations on locomotor muscle fatigue in patients with COPD (490)(491)(492). Collectively, these studies (491)(492)(493) have shown that respiratory muscle unloading (via oxygen and/or heliox breathing, bronchodilation, and proportional-assist ventilation) improves leg muscle oxygen availability during exercise in patients with COPD.…”
Section: Assessment Of Muscle Oxygenation Using Near-infrared and Magmentioning
confidence: 99%