Bronchoalveolar lavage in children with chronic diffuse parenchymal lung disease

Ronchetti, R; Midulla, Fabio; Sandström, Thomas; Bjermer, Lief; Zebrak, J; Pawlik, Jacek; Villa, Maria Pia; Villani, Alberto

doi:10.1002/(sici)1099-0496(199906)27:6<395::aid-ppul6>3.0.co;2-k

Cited by 12 publications

(6 citation statements)

References 34 publications

(23 reference statements)

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“…Infiltrating T cells are a characteristic feature of pulmonary tissue from ILD patients[45] and T cells in BALF were found to correlate with T cells in pulmonary tissue[46]. In line with previous findings[47,48], T cells were increased in BALF of our children with ILD as compared to control patients, suggesting a contribution of T cells to the pathogenesis of pediatric ILD. Studies in adult patients indicated that MCP-1 plays a role in the pathogenesis of different forms of ILD, including IPF[9,12,13], PAP[11,14], sarcoidosis[12], scleroderma with lung involvement[49] and granulomatous lung diseases[50].…”

Section: Discussionsupporting

confidence: 88%

A role for MCP-1/CCR2 in interstitial lung disease in children

et al. 2005

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Section: Discussionsupporting

confidence: 88%

A role for MCP-1/CCR2 in interstitial lung disease in children

et al. 2005

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“…It is recommended that the total volume of saline instilled is 361 mL?kg -1 in 10-20 mL aliquots. The return fluid of BAL is used for microbiological and cytological analysis, and in some specific cases for other cellular and noncellular studies [42,43].…”

Section: Bal Studiesmentioning

confidence: 99%

Task force on chronic interstitial lung disease in immunocompetent children

Clément

2004

European Respiratory Journal

161

163

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Chronic interstitial lung diseases in children represent a heterogeneous group of disorders of both known and unknown causes that share common histological features. Despite many efforts these diseases continue to present clinical management dilemmas, principally because of their rare frequency that limits considerably the possibilities of collecting enough cases for clinical and research studies. Through a Task Force conducted by the European Respiratory Society, which comprised respiratory physicians and basic scientists from across Europe, 185 cases of interstitial lung diseases in immunocompetent children were collected and reviewed. The present report provides important clinically-relevant information on the current approach to diagnosis and management of chronic interstitial lung diseases in children. In addition, recommendations for the management of paediatric interstitial lung diseases, as well as new insights into interstitial lung diseases pathophysiology during childhood are discussed

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“…[12][13][14][15][16][17][18][19][20][21]. In neonates it is possible to use the 2.8-mm bronchoscope with a 1.2-mm working channel.…”

Section: Bronchoalveolar Lavage Techniquesmentioning

confidence: 99%

“…In these patients, BAL may have an important role in reaching or confirming a specific diagnosis, in characterizing the alveolitis and in monitoring the patient during treatment and follow-up [20].…”

Section: Chronic Interstitial Lung Diseasementioning

confidence: 99%

Bronchoalveolar Lavage: Indications and Applications

Midulla¹,

Nenna²

2010

Paediatric Bronchoscopy

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Bronchoalveolar lavage (BAL) is a diagnostic procedure used to recover cellular and non-cellular components of the epithelial lining fluid from the alveolar and bronchial airspaces. Two types of the procedure have been described: bronchoscopic and non-bronchoscopic BAL. The preferred site for bronchoscopic BAL is the middle lobe or the lingula. Gentle manual or mechanical aspiration is applied in order to collect the lavage specimen in the collection trap, while the tip of the flexible bronchoscope is maintained wedged in the bronchus of the selected lavage site. The parameters measured in BAL fluid (BALF) include the percentage of the instilled normal saline that is recovered as well as various BALF cellular and non-cellular components. BAL is performed for diagnostic, therapeutic and research purposes. The most common indication for BAL is the investigation of lower respiratory tract infection. In chronic interstitial lung disease, BAL may have an important role in reaching a specific diagnosis, characterizing alveolitis, and monitoring patients during treatment and follow-up. BAL is still considered the gold standard for diagnosing chronic pulmonary aspiration. In general, BAL is a well-tolerated and safe procedure; however, on occasion, cough, transient wheezing and pulmonary infiltrates have been observed, which usually resolve within 24 h.

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Bronchoalveolar lavage in children with chronic diffuse parenchymal lung disease

Cited by 12 publications

References 34 publications

A role for MCP-1/CCR2 in interstitial lung disease in children

A role for MCP-1/CCR2 in interstitial lung disease in children

Task force on chronic interstitial lung disease in immunocompetent children

Bronchoalveolar Lavage: Indications and Applications

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