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Cited by 266 publications
(219 citation statements)
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References 29 publications
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“…This effect was magnitude-dependent. Furthermore, collagen type III was the most markedly increased of the three types investigated (I, III, and V), which is consistent with asthmaassociated airway wall thickening (5,(13)(14)(15). In fact, the entire integrated response-collagen synthesis, increased HBEC production of fibronectin, and increased MMP-9͞TIMP-1 ratiomimics many facets of the fibrotic response observed in patients with asthma, yet in the absence of inflammatory cells.…”
Section: Discussionsupporting
confidence: 74%
See 1 more Smart Citation
“…This effect was magnitude-dependent. Furthermore, collagen type III was the most markedly increased of the three types investigated (I, III, and V), which is consistent with asthmaassociated airway wall thickening (5,(13)(14)(15). In fact, the entire integrated response-collagen synthesis, increased HBEC production of fibronectin, and increased MMP-9͞TIMP-1 ratiomimics many facets of the fibrotic response observed in patients with asthma, yet in the absence of inflammatory cells.…”
Section: Discussionsupporting
confidence: 74%
“…These included collagen types I, III, and V, which are the primary types produced during asthma-related airway wall remodeling (5,(13)(14)(15), particularly type III. We also examined the presence of matrix metalloproteinase-9 (MMP-9) along with its inhibitor, tissue inhibitor of metalloproteinase-1…”
mentioning
confidence: 99%
“…Not surprisingly, then, the collagens up-regulated following egg exposure include types I, III, V, and XVIII, but not type IV. Interestingly, the subepithelial fibrosis manifested in asthma consists of collagens III and V, while the basal lamina, consisting of type IV, remains unchanged (43,44). Also, the ratio of collagens to each other is important.…”
Section: Discussionmentioning
confidence: 99%
“…Human studies reveal an association between severity of remodeling and AHR in asthma (Chetta et al, 1996;Hoshino et al, 1998), as well as a correlation between increasing subepithelial fibrosis and progression from asymptomatic AHR to asthma (Laprise et al, 1999). However, our previous studies using this experimental model suggest that remodeling and development of AHR can be uncoupled in IL-5-deficient animals, which develop significant airway wall remodeling but not AHR , as well as in IL-13-deficient animals, which do not exhibit remodeling but continue to be hyperreactive to methacholine (Kumar et al, 2002a).…”
Section: Foster Et Almentioning
confidence: 99%
“…This is of particular interest because AHR in asthmatics may correlate with the development of changes of remodeling, especially subepithelial fibrosis (Chetta et al, 1996;Hoshino et al, 1998). Increasing subepithelial fibrosis has also been associated with progression from asymptomatic AHR to asthma (Laprise et al, 1999).…”
mentioning
confidence: 99%