Broccoli extract improves high fat diet-induced obesity, hepatic steatosis and glucose intolerance in Wistar rats

Navarro‐Herrera, David; Romo-Hualde, Ana; Zabala, María; López-Yoldi, Miguel; González-Ferrero, Carolina; Gil, Ana Gloria; Martínéz, J. Alfredo; Vizmanos, José Luis; Milagro, Fermı́n I.; González-Navarro, Carlos J.

doi:10.1016/j.jff.2019.05.054

Cited by 23 publications

(22 citation statements)

References 38 publications

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“…In general, it is considered that the safe way to obtain bioactive compounds for human consumption, the ethanol is an excellent option (Shi et al., 2005). Aranaz et al., (2019) compared the extraction of bioactive compounds from broccoli with two different 70% solvents, ethanol and methanol, finding that there was no difference between the implementation of ethanol or methanol as extraction solvent in the quantitation of the total phenolic content.…”

Section: Extraction Of Bioactive Compoundsmentioning

confidence: 99%

The value of bioactive compounds of cruciferous vegetables (Brassica) as antimicrobials and antioxidants: A review

2020

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Nowadays, consumers are demanding nutrient-rich products for health optimal benefits. In this regard, Brassicaceae family plants, previously named cruciferous, group a large number of widely consumed species around the world. The popularity of Brassica is increasing due to their nutritional value and pharmacological effects. The group includes a large number of vegetable foods such as cabbages, broccoli, cauliflower, mustards as well as, oilseed rapeseed, canola, among others. In recent years, the phytochemical composition of Brassicaceae has been studied deeply because they contain many valuable metabolites, which are directly linked to different recognized biological activities. The scientific evidence confirms diverse medical properties for the treatment of chronic diseases such as obesity, type-2 diabetes, cardiovascular diseases (hypertension, stroke), cancer, and osteoporosis. The unique features of Brassicaceae family plants conferred by their phytochemicals, have extended future prospects about their use for beneficial effects on human nutrition and health worldwide. Practical applications For years, the Brassicaceae plants have been a fascinating research topic, due to their chemical composition characterized by rich in bioactive compounds. The implementation of extracts of these vegetables, causes various beneficial effects of high biological value in the treatment of diseases, owing to their bioactive properties (anti-obesity, anticancer, antimicrobial, antioxidant, hepatoprotective, cardioprotective, gastroprotective, anti-inflammatory, antianemic, and immunomodulator). Therefore, this review summarizes the chemical composition, describes the bioactive compounds isolated in the plant extracts, and highlights diverse biological activities, mainly the antimicrobial and antioxidant capacity. Brassica plants, as source of natural bioactive agents, have a great potential application to improve the human nutrition and health.

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Section: Extraction Of Bioactive Compoundsmentioning

confidence: 99%

The value of bioactive compounds of cruciferous vegetables (Brassica) as antimicrobials and antioxidants: A review

2020

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“…Aqueous extracts were made, since hydrodistillation is a widely used technique in the food industry and more environmentally friendly than the use of organic solvents . In other work, brassica extracts were obtained by static extraction of plant material at room temperature, in order to obtain ITCs . However, it has been reported that some ITCs have poor aqueous stability, such as SFN or erucin, which are partially degraded due to myrosinase activity .…”

Section: Discussionmentioning

confidence: 99%

“…46 In other work, brassica extracts were obtained by static extraction of plant material at room temperature, in order to obtain ITCs. 21,47 However, it has been reported that some ITCs have poor aqueous stability, such as SFN or erucin, which are partially degraded due to myrosinase activity. 22,23 Hence, the samples were extracted with boiling water in order to inactivate myrosinase, and with long enough extraction time (60 min) to also allow degradation because of thermal instability, 48 so we could see the different range of results from short to long or excessively long extraction procedures that allowed the selection of optimal extraction conditions for further work.…”

Section: Discussionmentioning

confidence: 99%

“…18 Furthermore, not only the ingredient by itself, but also Brassica-derived extracts are being used in the food industry as nutraceuticals, for food storage, or as prototype ingredients in the cosmetic industry. [19][20][21] However, these extracts are usually based in ITCs content with a lower shelf-life stability than GLSs. 22,23 The phytochemical composition of plant foods can be enriched by using elicitors, such as jasmonic acid and its methyl ester (methyl jasmonate, MeJA).…”

Section: Introductionmentioning

confidence: 99%

“…More recently, additional roles of the bioactives in Brassica species, in relation to diabetes and obesity, have been reported in preclinical studies and in nutritional interventions . Furthermore, not only the ingredient by itself, but also Brassica ‐derived extracts are being used in the food industry as nutraceuticals, for food storage, or as prototype ingredients in the cosmetic industry . However, these extracts are usually based in ITCs content with a lower shelf‐life stability than GLSs …”

Section: Introductionmentioning

confidence: 99%

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Use of elicitation in the cultivation of Bimi® for food and ingredients

et al. 2020

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BACKGROUND Cruciferous foods rich in health‐promoting metabolites are of particular interest to consumers as well as being a good source of bioactives‐enriched ingredients. Several elicitors have been used to stimulate the biosynthesis and accumulation of secondary metabolites in foods; however, little is known about the response of new hybrid varieties, such as Bimi®, under field‐crop production conditions. Therefore, this study was designed to evaluate the effect of salicylic acid (200 μmol L−1, SA), methyl jasmonate (100 μmol L−1, MeJA), and their combination on Bimi plant organs (inflorescences and aerial vegetative tissues – stems and leaves). For this, the composition of the glucosinolates present in the tissues was evaluated. Also, aqueous extracts of the plant material, obtained with different times of extraction with boiling water, were studied. RESULTS The results indicate that the combined treatment (SA + MeJA) significantly increased the content of glucosinolates in the inflorescences and that MeJA was the most effective elicitor in leaves. Regarding the aqueous extracts, the greatest amount of glucosinolates was extracted at 30 min – except for the leaves elicited with MeJA, for which 15 min was optimal. CONCLUSION The elicitation in the field enriched leaves in glucobrassicin (GB), 4‐methoxyglucobrassicin (MGB), and neoglucobrassicin (NGB) and stems and inflorescences in glucoraphanin, 4‐hydroxyglucobrassicin, GB, MGB, and NGB. In this way, this enhanced vegetable material favored the presence of bioactives in the extracts, which is of great interest regarding enriched foods and ingredients with added value obtained from them. © 2019 Society of Chemical Industry

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Camellia nitidissima Chi flower extract alleviates obesity and related complications and modulates gut microbiota composition in rats with high‐fat‐diet‐induced obesity

Zhang

Qin

2020

J Sci Food Agric

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BACKGROUNDThe aim of this study was to investigate the potential anti‐obesity effects of Camellia nitidissima Chi flower extract (Cnfe) by examining its effects in terms of the regulation of lipid levels and modulation of gut microbiota in rats with high‐fat‐diet‐induced obesity.RESULTSOur results demonstrated that Cnfe significantly decreased weight gain by reducing appetite and decreasing high‐fat food intake. Further, Cnfe restored normal lipid metabolism and improved insulin sensitivity and glucose tolerance in rats fed a high‐fat diet. Real‐time reverse transcription polymerase chain reaction and western blot results showed that Cnfe significantly decreased the expression of genes and proteins involved in adipogenesis and lipogenesis, and upregulated the expression of lipolysis genes. 16S ribosomal RNA sequencing of feces showed that Cnfe dramatically reversed dysbacteriosis in rats with high‐fat‐diet‐induced obesity by decreasing the abundance of Firmicutes and increasing that of Bacteroidetes and Verrucomicrobia at the phylum level.CONCLUSIONThe results demonstrate that Cnfe is a potential anti‐obesity prebiotic nutrient that can prevent weight gain, ameliorate obesity‐related dyslipidemia and hyperglycemia, inhibit liver fat accumulation, and modulate gut microbiota. © 2020 Society of Chemical Industry

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Broccoli extract improves high fat diet-induced obesity, hepatic steatosis and glucose intolerance in Wistar rats

Cited by 23 publications

References 38 publications

The value of bioactive compounds of cruciferous vegetables (Brassica) as antimicrobials and antioxidants: A review

The value of bioactive compounds of cruciferous vegetables (Brassica) as antimicrobials and antioxidants: A review

Use of elicitation in the cultivation of Bimi® for food and ingredients

Camellia nitidissima Chi flower extract alleviates obesity and related complications and modulates gut microbiota composition in rats with high‐fat‐diet‐induced obesity

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