Broad-spectrum antimicrobial activity of hemoglobin

Parish, Craig A.; Jiang, Hong; Tokiwa, Y.; Berova, Nina; Nakanishi, Koji; McCabe, Denise; Zuckerman, Warren A.; Xia, Ming Ming; Gabay, Joëlle E.

doi:10.1016/s0968-0896(00)00263-7

Cited by 120 publications

(97 citation statements)

References 27 publications

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“…Aktiviti bakteria daripada dua kes diuji pada hemosidin daripada pelepasan haid (alpha-globin, sisa 35-56, dan betaglobin, sisa 115-146, (Jadual 1) adalah sama dengan yang ditentukan dalam penyelidikan lain (Liepke et al 2003;Parish et al 2001), kedua-dua dalam kes nilai MIC (dari puluhan ke ratusan μM) serta keberkesanannya terhadap bakteria Gram-negatif. Satu-satunya perbezaan adalah kekurangan aktiviti ke arah C. albicans.…”

Section: Pendahuluanunclassified

Haid daripada Perspektif Sains dan Maqasid Syariah

Hasim

Kashim²,

Othaman³

et al. 2016

JSM

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Each natural occurrence is a blessing and gives benefit to human being such as menstruation in women. Menstruation is a unique and planned process, which involves three main phases (Muhammad Adib et. al 2015). Kerahmatan ini dapat dilihat melalui kejadian semula jadi yang dicipta oleh Allah SWT. Misalnya keseluruhan anggota tubuh badan manusia dicipta dengan fungsi masing-masing bertujuan untuk memberi kebahagiaan dan kesejahteraan kepada manusia itu sendiri. Mata dicipta untuk melihat.Begitu juga fungsi telinga ialah untuk mendengar. Keduadua anggota badan yang dipilih sebagai contoh ini adalah manifestasi kepada sifat rahmat Allah SWT. Selain itu, kejadian semula jadi yang juga mendatangkan rahmat juga membawa kemaslahatan kepada manusia ialah pendarahan haid. Dengan kata lain, pendarahan haid kepada insan bergelar wanita adalah dengan kehendak Allah SWT dalam menjaga kemaslahatan mereka atau nama lainnya maqasid syariah.Haid jika dilihat daripada karya-karya fiqh bermaksud darah yang keluar dari pangkal rahim dalam tempoh yang tertentu secara tabii melalui faraj wanita dalam keadaan sihat, bukan sebab melahirkan anak (al-Sharbini 1994).

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Section: Pendahuluanunclassified

Haid daripada Perspektif Sains dan Maqasid Syariah

Hasim

Kashim²,

Othaman³

et al. 2016

JSM

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“…Studies have shown that the respiratory protein hemoglobin can produce ROS (Jiang et al, 2007). Recently, studies have also shown that antibacterial peptides derived from hemoglobins and intact hemoglobins have antibacterial activity in some higher vertebrates (Parish et al, 2001;Nedjar-Arroume et al, 2008). Studies have also demonstrated that hemoglobin is able to detect, scavenge, and detoxify NO; NO detoxification has been linked to bacterial resistance (Gardner and Gardner, 2002;Wajcman et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to supporting aerobic metabolism by providing O 2 , hemoglobins fulfill a broad range of other functions including O 2 sensing, detoxification of harmful reactive oxygen species (ROS), signaling in oxygen-dependent metabolic pathways, and production and elimination of NO (Terwilliger, 1998;Wajcman et al, 2009;Ebner et al, 2010). Hemoglobin (Hb) is also a source of antibacterial peptides in many animals; intact hemoglobin and its fractions exhibit antimicrobial activity against Gram-positive and -negative bacteria (Parish et al, 2001;Nedjar-Arroume et al, 2008). Human Hb can induce oxidative stress that may contribute to MMP-9 activation and BBB dysfunction, leading to apoptosis in vivo (Katsu et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Structure and immune expression analysis of hemoglobin genes from the blood clam Tegillarca granosa

Bao

Wang²,

Zhang³

2013

Genet. Mol. Res.

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ABSTRACT. Hemoglobin (Hb) is the major protein component of erythrocytes in animals with red blood, although it can serve additional functions beyond the transport of oxygen. The blood clam (Tegillarca granosa) is one of the few mollusks that has Hb, although the structure and function of molluskan Hbs remain unclear. We characterized two unique and highly compartmentalized blood clam hemoglobin genes, Tg-HbIIA and Tg-HbIIB, at the molecular level. The full-length cDNA of Tg-HbIIA was 731 bp with a 450-bp open reading frame encoding 150 amino acids; that of Tg-HbIIB was 698 bp, with a 456-bp open reading frame encoding 152 amino acids. Their intronic regions were amplified by PCR. The two genes showed the typical 2 intron/3 exon organization found in T. granosa. The 3-D structures of the three blood clam Tg-Hbs were predicted using the SWISS-MODEL Protein Modeling Server, and a phylogenetic analysis was conducted to investigate its evolution. As quantified by qRT-PCR, the expression levels of Tg-HbIIA and Tg-HbIIB were significantly upregulated upon challenge by Vibrio

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“…Sequences of other proteins such as Creactive protein Ig heaving chain, phospholipase A2, hemoglobin, b-defensins, lactoferrin and granulysin possess anti-inflammatory activities with the function being expressed upon the degradation of the parent protein (King et al, 2002;King et al, 2003;King et al 2007;Miele et al 1988;Parish et al, 2001;Rawlings et al, 2008;Robey et al, 1987).…”

Section: Discussionmentioning

confidence: 99%